Hierarchical Optimization on large models.

<p>A: Schematic of hierarchical optimization as implemented in HOSS. First, the upper level of the model hierarchy is optimized, in this case the CaM and b2AR sub-models. Each is individually optimized, and any of the standard algorithms such as BFGS or COBYLA may be employed. Experiments spec...

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محفوظ في:

التفاصيل البيبلوغرافية
المؤلف الرئيسي:	Nisha Ann Viswan (20371285) (author)
مؤلفون آخرون:	Alexandre Tribut (20371288) (author), Manvel Gasparyan (14250300) (author), Ovidiu Radulescu (266188) (author), Upinder S. Bhalla (11768249) (author)
منشور في:	2024
الموضوعات:	Ecology Plant Biology Computational Biology Biological Sciences not elsewhere classified Mathematical Sciences not elsewhere classified Information Systems not elsewhere classified huge parameter space given biochemical network frequently encounter multiscale subsequent levels rely necessary nested hierarchies extensive systems models systems simulations succeeding levels nested hierarchy sparse data solution degeneracy signalling inputs results indicate preceding ones pathway serves multiphysics phenomena mathematical basis intermediate stages independent pathway held constant first level every level based simulations algorithmic approach
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Hierarchical Optimization on large models.

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