Biofilm formation and tavaborole effect on mature biofilm of five <i>Acinetobacter baumannii</i> strains in polystyrene plates.
<p>(A) Quantification of biofilm biomass formed after 48h incubation without the presence of the investigated drug determined through OD reading at 595 nm. Each symbol represents the mean of triplicates. (B) Percentage of OD reduction for biofilm biomass treated with 16 μg/ml tavaborole for 24...
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2024
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| _version_ | 1852026357570076672 |
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| author | Kellen Christina Malheiros Borges (11021617) |
| author2 | Vinícius Alexandre Fiaia Costa (19746550) Bruno Neves Junior (19746553) André Kipnis (125248) Ana Paula Junqueira-Kipnis (10372081) |
| author2_role | author author author author |
| author_facet | Kellen Christina Malheiros Borges (11021617) Vinícius Alexandre Fiaia Costa (19746550) Bruno Neves Junior (19746553) André Kipnis (125248) Ana Paula Junqueira-Kipnis (10372081) |
| author_role | author |
| dc.creator.none.fl_str_mv | Kellen Christina Malheiros Borges (11021617) Vinícius Alexandre Fiaia Costa (19746550) Bruno Neves Junior (19746553) André Kipnis (125248) Ana Paula Junqueira-Kipnis (10372081) |
| dc.date.none.fl_str_mv | 2024-09-26T17:36:43Z |
| dc.identifier.none.fl_str_mv | 10.1371/journal.pone.0307913.g002 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/figure/Biofilm_formation_and_tavaborole_effect_on_mature_biofilm_of_five_i_Acinetobacter_baumannii_i_strains_in_polystyrene_plates_/27113281 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Biochemistry Microbiology Pharmacology Biotechnology Immunology Cancer Infectious Diseases Environmental Sciences not elsewhere classified Biological Sciences not elsewhere classified Chemical Sciences not elsewhere classified preparing proteomic data new antibacterial candidates identifying homologous proteins high resistance rate computational chemogenomics framework tavaborole shows promise minimum inhibitory concentration driven chemogenomics repurposing promising antimicrobial activity acinetobacter baumannii </ antimicrobial activity baumannii </ potent activity antimicrobial agent worldwide gram vitro </ trna synthetase tavaborole exhibited structural basis seven drugs robust efficacy resistant strains providing insights negative bacterium evolutionary conservation broad spectrum binding modes approved drugs active domains 2 μg 16 μg |
| dc.title.none.fl_str_mv | Biofilm formation and tavaborole effect on mature biofilm of five <i>Acinetobacter baumannii</i> strains in polystyrene plates. |
| dc.type.none.fl_str_mv | Image Figure info:eu-repo/semantics/publishedVersion image |
| description | <p>(A) Quantification of biofilm biomass formed after 48h incubation without the presence of the investigated drug determined through OD reading at 595 nm. Each symbol represents the mean of triplicates. (B) Percentage of OD reduction for biofilm biomass treated with 16 μg/ml tavaborole for 24h. (C) Metabolic activity reduction rate recorded for biofilm treated with 16 μg/ml tavaborole for 24h. The bars represent the mean and standard deviation of different experiments. Three independent experiments were performed.</p> |
| eu_rights_str_mv | openAccess |
| id | Manara_4a5ec66440e95c42dfef2d6f4e27f0bf |
| identifier_str_mv | 10.1371/journal.pone.0307913.g002 |
| network_acronym_str | Manara |
| network_name_str | ManaraRepo |
| oai_identifier_str | oai:figshare.com:article/27113281 |
| publishDate | 2024 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | Biofilm formation and tavaborole effect on mature biofilm of five <i>Acinetobacter baumannii</i> strains in polystyrene plates.Kellen Christina Malheiros Borges (11021617)Vinícius Alexandre Fiaia Costa (19746550)Bruno Neves Junior (19746553)André Kipnis (125248)Ana Paula Junqueira-Kipnis (10372081)BiochemistryMicrobiologyPharmacologyBiotechnologyImmunologyCancerInfectious DiseasesEnvironmental Sciences not elsewhere classifiedBiological Sciences not elsewhere classifiedChemical Sciences not elsewhere classifiedpreparing proteomic datanew antibacterial candidatesidentifying homologous proteinshigh resistance ratecomputational chemogenomics frameworktavaborole shows promiseminimum inhibitory concentrationdriven chemogenomics repurposingpromising antimicrobial activityacinetobacter baumannii </antimicrobial activitybaumannii </potent activityantimicrobial agentworldwide gramvitro </trna synthetasetavaborole exhibitedstructural basisseven drugsrobust efficacyresistant strainsproviding insightsnegative bacteriumevolutionary conservationbroad spectrumbinding modesapproved drugsactive domains2 μg16 μg<p>(A) Quantification of biofilm biomass formed after 48h incubation without the presence of the investigated drug determined through OD reading at 595 nm. Each symbol represents the mean of triplicates. (B) Percentage of OD reduction for biofilm biomass treated with 16 μg/ml tavaborole for 24h. (C) Metabolic activity reduction rate recorded for biofilm treated with 16 μg/ml tavaborole for 24h. The bars represent the mean and standard deviation of different experiments. Three independent experiments were performed.</p>2024-09-26T17:36:43ZImageFigureinfo:eu-repo/semantics/publishedVersionimage10.1371/journal.pone.0307913.g002https://figshare.com/articles/figure/Biofilm_formation_and_tavaborole_effect_on_mature_biofilm_of_five_i_Acinetobacter_baumannii_i_strains_in_polystyrene_plates_/27113281CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/271132812024-09-26T17:36:43Z |
| spellingShingle | Biofilm formation and tavaborole effect on mature biofilm of five <i>Acinetobacter baumannii</i> strains in polystyrene plates. Kellen Christina Malheiros Borges (11021617) Biochemistry Microbiology Pharmacology Biotechnology Immunology Cancer Infectious Diseases Environmental Sciences not elsewhere classified Biological Sciences not elsewhere classified Chemical Sciences not elsewhere classified preparing proteomic data new antibacterial candidates identifying homologous proteins high resistance rate computational chemogenomics framework tavaborole shows promise minimum inhibitory concentration driven chemogenomics repurposing promising antimicrobial activity acinetobacter baumannii </ antimicrobial activity baumannii </ potent activity antimicrobial agent worldwide gram vitro </ trna synthetase tavaborole exhibited structural basis seven drugs robust efficacy resistant strains providing insights negative bacterium evolutionary conservation broad spectrum binding modes approved drugs active domains 2 μg 16 μg |
| status_str | publishedVersion |
| title | Biofilm formation and tavaborole effect on mature biofilm of five <i>Acinetobacter baumannii</i> strains in polystyrene plates. |
| title_full | Biofilm formation and tavaborole effect on mature biofilm of five <i>Acinetobacter baumannii</i> strains in polystyrene plates. |
| title_fullStr | Biofilm formation and tavaborole effect on mature biofilm of five <i>Acinetobacter baumannii</i> strains in polystyrene plates. |
| title_full_unstemmed | Biofilm formation and tavaborole effect on mature biofilm of five <i>Acinetobacter baumannii</i> strains in polystyrene plates. |
| title_short | Biofilm formation and tavaborole effect on mature biofilm of five <i>Acinetobacter baumannii</i> strains in polystyrene plates. |
| title_sort | Biofilm formation and tavaborole effect on mature biofilm of five <i>Acinetobacter baumannii</i> strains in polystyrene plates. |
| topic | Biochemistry Microbiology Pharmacology Biotechnology Immunology Cancer Infectious Diseases Environmental Sciences not elsewhere classified Biological Sciences not elsewhere classified Chemical Sciences not elsewhere classified preparing proteomic data new antibacterial candidates identifying homologous proteins high resistance rate computational chemogenomics framework tavaborole shows promise minimum inhibitory concentration driven chemogenomics repurposing promising antimicrobial activity acinetobacter baumannii </ antimicrobial activity baumannii </ potent activity antimicrobial agent worldwide gram vitro </ trna synthetase tavaborole exhibited structural basis seven drugs robust efficacy resistant strains providing insights negative bacterium evolutionary conservation broad spectrum binding modes approved drugs active domains 2 μg 16 μg |