Repeat Fig. 4 original dataset for Bacteria loaded with glucose polymer and photosensitive ICG silicon-nanoparticles for glioblastoma photothermal immunotherapy
<p dir="ltr">Bacteria can bypass the blood-brain barrier (BBB), suggesting the possibility of employment of bacteria for combating central nervous system diseases. Herein, we develop a bacteria-based drug delivery system for glioblastoma (GBM) photothermal immunotherapy. The system,...
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2025
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| _version_ | 1849927630537621504 |
|---|---|
| author | Rong Sun (532754) |
| author_facet | Rong Sun (532754) |
| author_role | author |
| dc.creator.none.fl_str_mv | Rong Sun (532754) |
| dc.date.none.fl_str_mv | 2025-11-25T14:33:17Z |
| dc.identifier.none.fl_str_mv | 10.6084/m9.figshare.30630257.v2 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/figure/Repeat_Fig_4_original_dataset_for_Bacteria_loaded_with_glucose_polymer_and_photosensitive_ICG_silicon-nanoparticles_for_glioblastoma_photothermal_immunotherapy/30630257 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Bacteriology glioblastoma (GB) |
| dc.title.none.fl_str_mv | Repeat Fig. 4 original dataset for Bacteria loaded with glucose polymer and photosensitive ICG silicon-nanoparticles for glioblastoma photothermal immunotherapy |
| dc.type.none.fl_str_mv | Image Figure info:eu-repo/semantics/publishedVersion image |
| description | <p dir="ltr">Bacteria can bypass the blood-brain barrier (BBB), suggesting the possibility of employment of bacteria for combating central nervous system diseases. Herein, we develop a bacteria-based drug delivery system for glioblastoma (GBM) photothermal immunotherapy. The system, which we name as ‘Trojan bacteria’, consists of bacteria loaded with glucose polymer and photosensitive ICG silicon-nanoparticles. In an orthotopic GBM mouse model, we demonstrate that the intravenously injected bacteria bypass the BBB, targeting and penetrating GBM tissues. Upon 808 nm-laser irradiation, the photothermal effects produced by ICG allow the destruction of bacterial cells and the adjacent tumour cells. Furthermore, the bacterial debris as well as the tumour-associated antigens promote antitumor immune responses that prolong the survival of GBM-bearing mice. Moreover, we demonstrate the residual bacteria are effectively eliminated from the body, supporting the potential therapeutic use of this system.</p> |
| eu_rights_str_mv | openAccess |
| id | Manara_4b25abe3c9fb0ecfcd1931985cdbd26a |
| identifier_str_mv | 10.6084/m9.figshare.30630257.v2 |
| network_acronym_str | Manara |
| network_name_str | ManaraRepo |
| oai_identifier_str | oai:figshare.com:article/30630257 |
| publishDate | 2025 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | Repeat Fig. 4 original dataset for Bacteria loaded with glucose polymer and photosensitive ICG silicon-nanoparticles for glioblastoma photothermal immunotherapyRong Sun (532754)Bacteriologyglioblastoma (GB)<p dir="ltr">Bacteria can bypass the blood-brain barrier (BBB), suggesting the possibility of employment of bacteria for combating central nervous system diseases. Herein, we develop a bacteria-based drug delivery system for glioblastoma (GBM) photothermal immunotherapy. The system, which we name as ‘Trojan bacteria’, consists of bacteria loaded with glucose polymer and photosensitive ICG silicon-nanoparticles. In an orthotopic GBM mouse model, we demonstrate that the intravenously injected bacteria bypass the BBB, targeting and penetrating GBM tissues. Upon 808 nm-laser irradiation, the photothermal effects produced by ICG allow the destruction of bacterial cells and the adjacent tumour cells. Furthermore, the bacterial debris as well as the tumour-associated antigens promote antitumor immune responses that prolong the survival of GBM-bearing mice. Moreover, we demonstrate the residual bacteria are effectively eliminated from the body, supporting the potential therapeutic use of this system.</p>2025-11-25T14:33:17ZImageFigureinfo:eu-repo/semantics/publishedVersionimage10.6084/m9.figshare.30630257.v2https://figshare.com/articles/figure/Repeat_Fig_4_original_dataset_for_Bacteria_loaded_with_glucose_polymer_and_photosensitive_ICG_silicon-nanoparticles_for_glioblastoma_photothermal_immunotherapy/30630257CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/306302572025-11-25T14:33:17Z |
| spellingShingle | Repeat Fig. 4 original dataset for Bacteria loaded with glucose polymer and photosensitive ICG silicon-nanoparticles for glioblastoma photothermal immunotherapy Rong Sun (532754) Bacteriology glioblastoma (GB) |
| status_str | publishedVersion |
| title | Repeat Fig. 4 original dataset for Bacteria loaded with glucose polymer and photosensitive ICG silicon-nanoparticles for glioblastoma photothermal immunotherapy |
| title_full | Repeat Fig. 4 original dataset for Bacteria loaded with glucose polymer and photosensitive ICG silicon-nanoparticles for glioblastoma photothermal immunotherapy |
| title_fullStr | Repeat Fig. 4 original dataset for Bacteria loaded with glucose polymer and photosensitive ICG silicon-nanoparticles for glioblastoma photothermal immunotherapy |
| title_full_unstemmed | Repeat Fig. 4 original dataset for Bacteria loaded with glucose polymer and photosensitive ICG silicon-nanoparticles for glioblastoma photothermal immunotherapy |
| title_short | Repeat Fig. 4 original dataset for Bacteria loaded with glucose polymer and photosensitive ICG silicon-nanoparticles for glioblastoma photothermal immunotherapy |
| title_sort | Repeat Fig. 4 original dataset for Bacteria loaded with glucose polymer and photosensitive ICG silicon-nanoparticles for glioblastoma photothermal immunotherapy |
| topic | Bacteriology glioblastoma (GB) |