Table 1_Weight loss increases circadian gene expression and emotional well-being in individuals with obesity.docx
Introduction<p>Obesity is associated with disruptions in circadian rhythms and emotional well-being that can contribute to metabolic and psychological health issues. This study aimed to investigate the effects of weight loss by a dietary intervention on circadian gene expression and emotional...
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2025
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| _version_ | 1849927624755773440 |
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| author | Carmen Grau-del Valle (22686341) |
| author2 | Neus Bosch-Sierra (22686344) Alberto Hermo-Argibay (22686347) Sandra López-Domenech (22686350) Milagros Rocha (479608) Víctor M. Víctor (22686353) Carlos Morillas (479612) Susana Rovira-Llopis (479611) Celia Bañuls (479609) |
| author2_role | author author author author author author author author |
| author_facet | Carmen Grau-del Valle (22686341) Neus Bosch-Sierra (22686344) Alberto Hermo-Argibay (22686347) Sandra López-Domenech (22686350) Milagros Rocha (479608) Víctor M. Víctor (22686353) Carlos Morillas (479612) Susana Rovira-Llopis (479611) Celia Bañuls (479609) |
| author_role | author |
| dc.creator.none.fl_str_mv | Carmen Grau-del Valle (22686341) Neus Bosch-Sierra (22686344) Alberto Hermo-Argibay (22686347) Sandra López-Domenech (22686350) Milagros Rocha (479608) Víctor M. Víctor (22686353) Carlos Morillas (479612) Susana Rovira-Llopis (479611) Celia Bañuls (479609) |
| dc.date.none.fl_str_mv | 2025-11-26T05:14:39Z |
| dc.identifier.none.fl_str_mv | 10.3389/fnut.2025.1722428.s001 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/dataset/Table_1_Weight_loss_increases_circadian_gene_expression_and_emotional_well-being_in_individuals_with_obesity_docx/30717560 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Clinical and Sports Nutrition obesity weight loss circadian rhythm self-esteem depression anxiety clock genes |
| dc.title.none.fl_str_mv | Table 1_Weight loss increases circadian gene expression and emotional well-being in individuals with obesity.docx |
| dc.type.none.fl_str_mv | Dataset info:eu-repo/semantics/publishedVersion dataset |
| description | Introduction<p>Obesity is associated with disruptions in circadian rhythms and emotional well-being that can contribute to metabolic and psychological health issues. This study aimed to investigate the effects of weight loss by a dietary intervention on circadian gene expression and emotional state in individuals with obesity.</p>Methods<p>Fifty subjects with obesity followed a dietary intervention for 6 months. Anthropometric and biochemical parameters were assessed. Sleep quality was measured using a sleep questionnaire and Rosemberg Self-Esteem Scale, Beck Depression Inventory and State-Trait Anxiety Inventory (STAI) were used. PBMCs’ RNA was analyzed for circadian-related gene expression.</p>Results<p>Participants lost 11.3% body weight, along with reductions in lipid, carbohydrate metabolism and inflammation markers. Sleep quality improved; as poor sleep frequency was reduced, though sleep duration was similar. Self-esteem did not significantly increase; however, the proportion of participants with high self-esteem rose from 62 to 69% (χ<sup>2</sup> = 12.5, p < 0.05). State anxiety decreased (STAI-S, p < 0.01), though trait anxiety remained stable. Several circadian genes were upregulated, including CLOCK, ARNTL, CRY1, DBP, and NR1D1; with associations found between CLOCK and lower state anxiety at baseline, and between CRY2 and higher self-esteem and lower depression at baseline (p < 0.05).</p>Conclusion<p>The dietary intervention influenced positively the metabolic, psychological, and circadian rhythm marker profile, highlighting potential interconnections between metabolism, circadian gene expression, and mental well-being.</p>Clinical Trial Registration<p>Identifier NCT06279780</p> |
| eu_rights_str_mv | openAccess |
| id | Manara_4b589e1f8fd396384fd001dabcf71303 |
| identifier_str_mv | 10.3389/fnut.2025.1722428.s001 |
| network_acronym_str | Manara |
| network_name_str | ManaraRepo |
| oai_identifier_str | oai:figshare.com:article/30717560 |
| publishDate | 2025 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | Table 1_Weight loss increases circadian gene expression and emotional well-being in individuals with obesity.docxCarmen Grau-del Valle (22686341)Neus Bosch-Sierra (22686344)Alberto Hermo-Argibay (22686347)Sandra López-Domenech (22686350)Milagros Rocha (479608)Víctor M. Víctor (22686353)Carlos Morillas (479612)Susana Rovira-Llopis (479611)Celia Bañuls (479609)Clinical and Sports Nutritionobesityweight losscircadian rhythmself-esteemdepressionanxietyclock genesIntroduction<p>Obesity is associated with disruptions in circadian rhythms and emotional well-being that can contribute to metabolic and psychological health issues. This study aimed to investigate the effects of weight loss by a dietary intervention on circadian gene expression and emotional state in individuals with obesity.</p>Methods<p>Fifty subjects with obesity followed a dietary intervention for 6 months. Anthropometric and biochemical parameters were assessed. Sleep quality was measured using a sleep questionnaire and Rosemberg Self-Esteem Scale, Beck Depression Inventory and State-Trait Anxiety Inventory (STAI) were used. PBMCs’ RNA was analyzed for circadian-related gene expression.</p>Results<p>Participants lost 11.3% body weight, along with reductions in lipid, carbohydrate metabolism and inflammation markers. Sleep quality improved; as poor sleep frequency was reduced, though sleep duration was similar. Self-esteem did not significantly increase; however, the proportion of participants with high self-esteem rose from 62 to 69% (χ<sup>2</sup> = 12.5, p < 0.05). State anxiety decreased (STAI-S, p < 0.01), though trait anxiety remained stable. Several circadian genes were upregulated, including CLOCK, ARNTL, CRY1, DBP, and NR1D1; with associations found between CLOCK and lower state anxiety at baseline, and between CRY2 and higher self-esteem and lower depression at baseline (p < 0.05).</p>Conclusion<p>The dietary intervention influenced positively the metabolic, psychological, and circadian rhythm marker profile, highlighting potential interconnections between metabolism, circadian gene expression, and mental well-being.</p>Clinical Trial Registration<p>Identifier NCT06279780</p>2025-11-26T05:14:39ZDatasetinfo:eu-repo/semantics/publishedVersiondataset10.3389/fnut.2025.1722428.s001https://figshare.com/articles/dataset/Table_1_Weight_loss_increases_circadian_gene_expression_and_emotional_well-being_in_individuals_with_obesity_docx/30717560CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/307175602025-11-26T05:14:39Z |
| spellingShingle | Table 1_Weight loss increases circadian gene expression and emotional well-being in individuals with obesity.docx Carmen Grau-del Valle (22686341) Clinical and Sports Nutrition obesity weight loss circadian rhythm self-esteem depression anxiety clock genes |
| status_str | publishedVersion |
| title | Table 1_Weight loss increases circadian gene expression and emotional well-being in individuals with obesity.docx |
| title_full | Table 1_Weight loss increases circadian gene expression and emotional well-being in individuals with obesity.docx |
| title_fullStr | Table 1_Weight loss increases circadian gene expression and emotional well-being in individuals with obesity.docx |
| title_full_unstemmed | Table 1_Weight loss increases circadian gene expression and emotional well-being in individuals with obesity.docx |
| title_short | Table 1_Weight loss increases circadian gene expression and emotional well-being in individuals with obesity.docx |
| title_sort | Table 1_Weight loss increases circadian gene expression and emotional well-being in individuals with obesity.docx |
| topic | Clinical and Sports Nutrition obesity weight loss circadian rhythm self-esteem depression anxiety clock genes |