Phylogenomic Identification of a Highly Conserved Copper-Binding RiPP Biosynthetic Gene Cluster in Marine Microbulbifer Bacteria

Phylogenomic Identification of a Highly Conserved Copper-Binding RiPP Biosynthetic Gene Cluster in Marine Microbulbifer Bacteria

Conserved biosynthetic gene clusters (BGCs) are often tied to the production of natural products that perform critical functions in an organism’s physiology and ecological interactions. Here, by phylogenetic analysis across the bacterial genus, we report the obligate conservation of a BGC in genomes...

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Main Author: Yifan Tang (1269402) (author)
Other Authors: Weimao Zhong (5519135) (author), Longping Fu (11727875) (author), Emmanuel Asante (22277327) (author), Anastasiia Kostenko (6939998) (author), F. N. U. Vidya (19935264) (author), Paige Mandelare-Ruiz (12041634) (author), Tamilore T. Adeogun (22277330) (author), Gabriel P. Anderson (22277333) (author), Benjamin E. Edmonds (22277336) (author), Oscar Fang (22277339) (author), Michelle Han (1618693) (author), Alia S. Hollingsworth (22277342) (author), Amna R. Ingham (22277345) (author), Carlyn R. Kirby (22277348) (author), Alice Landrum (22277351) (author), Connor R. Mack (22277354) (author), Nikki S. Nobari (22277357) (author), Emma J. Oswald (22277360) (author), Cecilia L. Polevoy (22277363) (author), Yasmin Sharifian (22277366) (author), Timothy J. So (22277369) (author), Joelee R. Stokes (22277372) (author), Reniya S. Thompson (22277375) (author), Rishabh Vuthamaraju (22277378) (author), Elaine C. Wang (22277381) (author), William H. Yang (4405492) (author), Alison E. Onstine (22277384) (author), Valerie J. Paul (307783) (author), Ronghu Wu (1643710) (author), Allegra T. Aron (14607873) (author), Vinayak Agarwal (1335897) (author)
Published: 2025
Subjects:
Biochemistry
Microbiology
Genetics
Evolutionary Biology
Ecology
Inorganic Chemistry
Environmental Sciences not elsewhere classified
Biological Sciences not elsewhere classified
structure elucidated using
perform critical functions
nmr spectroscopy 
natural product chemistry
phylogenetic analysis across
microbulbifer genomes regardless
highly conserved copper
natural products
copper chelator
undergraduate students
provide hands
phylogenomic identification
pedagogic setting
organism ’
often tied
obligate conservation
mass spectrometry
georgia institute
geographical dispersal
genome mining
ecological interactions
common member
bgc 
bacterial phylogeny
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