Inference of the DFE assuming different dominance coefficients under a gamma distribution.

Inference of the DFE assuming different dominance coefficients under a gamma distribution.

<p>E[s] represents the expected selection coefficient, which is computed as <i>α</i>*<i>β</i>/<i>N</i><sub><i>anc</i></sub>. AIC refers to the Akaike information criterion based on model log-likelihood and number of parameters.</p&...

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Bibliographic Details
Main Author:	Christopher C. Kyriazis (19713344) (author)
Other Authors:	Kirk E. Lohmueller (8026796) (author)
Published:	2024
Subjects:	Genetics Evolutionary Biology Ecology Science Policy Infectious Diseases Biological Sciences not elsewhere classified site frequency spectrum slight decreases shown inform simulations revisiting single dominance coefficient selection coefficient (< results also demonstrate dominance coefficient (< weakly recessive models strongly recessive models div >< p african populations depends african human populations dominance model assumed strongly deleterious mutations molecular population genetics natural populations slight increases simulations suggest model organisms selection parameters nonsynonymous mutations natural selection explore dominance estimated dominance beneficial mutations also observe predicted models parameterizing models including models fitting models constraining models work represents relative burden negative relationship key reason inbreeding depression genetic variation genetic load fundamental parameter extremely challenging direct measures deleterious variation comprehensive assessment africa bottleneck
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