Modular Bioorthogonal Lipid Nanoparticle Modification Platforms for Cardiac Homing

Lipid nanoparticles (LNPs) are becoming widely adopted as vectors for the delivery of therapeutic payloads but generally lack intrinsic tissue-homing properties. These extracellular vesicle (EV) mimetics can be targeted toward the liver, lung, or spleen via charge modification of their lipid headgro...

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Bibliographic Details
Main Author:	Raquel Cruz-Samperio (17118708) (author)
Other Authors:	Corrigan L. Hicks (17118711) (author), Aaron Scott (151313) (author), Ignacio Gispert Contamina (17118714) (author), Yuval Elani (5522963) (author), Rebecca J. Richardson (11982584) (author), Adam W. Perriman (1711612) (author)
Published:	2023
Subjects:	Biophysics Biochemistry Medicine Cell Biology Genetics Pharmacology Biotechnology Sociology Cancer Inorganic Chemistry Space Science Biological Sciences not elsewhere classified Chemical Sciences not elsewhere classified Physical Sciences not elsewhere classified rich c2c12 cells functional module containing becoming widely adopted bacterial adhesin csha two protein modules show targeted localization lnps modified using targeted toward modified lnps binding protein zebrafish hearts therapeutic potential therapeutic payloads static conditions scale manufacturing molecule ligands lnps postformation lipid headgroups fold increase extracellular vesicle electrostatically conjugated cell viability cardiac disease
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Modular Bioorthogonal Lipid Nanoparticle Modification Platforms for Cardiac Homing

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