Sandcastle Worm-Inspired Polyelectrolyte Hydrogel as a Bioadhesive for Diverse Tissues
Bioadhesives have been widely applied in wound healing and hemostasis, as well as biointegrated devices. Most existing bioadhesives still lack fast adhesion formation, strong interfacial toughness, and outstanding compatibility in humidity environments. Here, we synthesized a polyampholyte hydrogel...
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| مؤلفون آخرون: | , , , , , , , , |
| منشور في: |
2025
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| الموضوعات: | |
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| _version_ | 1852016777046786048 |
|---|---|
| author | Jing Cong (519038) |
| author2 | Xiaoming Liu (47653) Chengpan Li (10675845) Lin Mei (300443) Shaoshan Pan (11147050) Jie Tian (20496) Tianyu Xu (6794144) Chunguang Miao (4379080) Weiping Ding (721500) Tianzhi Luo (1460182) |
| author2_role | author author author author author author author author author |
| author_facet | Jing Cong (519038) Xiaoming Liu (47653) Chengpan Li (10675845) Lin Mei (300443) Shaoshan Pan (11147050) Jie Tian (20496) Tianyu Xu (6794144) Chunguang Miao (4379080) Weiping Ding (721500) Tianzhi Luo (1460182) |
| author_role | author |
| dc.creator.none.fl_str_mv | Jing Cong (519038) Xiaoming Liu (47653) Chengpan Li (10675845) Lin Mei (300443) Shaoshan Pan (11147050) Jie Tian (20496) Tianyu Xu (6794144) Chunguang Miao (4379080) Weiping Ding (721500) Tianzhi Luo (1460182) |
| dc.date.none.fl_str_mv | 2025-09-10T06:30:15Z |
| dc.identifier.none.fl_str_mv | 10.1021/acsapm.5c02092.s003 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/media/Sandcastle_Worm-Inspired_Polyelectrolyte_Hydrogel_as_a_Bioadhesive_for_Diverse_Tissues/30093126 |
| dc.rights.none.fl_str_mv | CC BY-NC 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Biophysics Biochemistry Medicine Molecular Biology Biotechnology Developmental Biology Cancer Space Science Biological Sciences not elsewhere classified Chemical Sciences not elsewhere classified Physical Sciences not elsewhere classified wet tissue surface potential medical applications 2 -( dimethylamino strong interfacial toughness outstanding mechanical properties diverse tissues bioadhesives inspired polyelectrolyte hydrogel various tissues strong adhesion outstanding compatibility wound healing wound care widely applied vivo </ vitro </ suppressing inflammation sandcastle worms sandcastle worm physiological conditions humidity environments ethyl methacrylate biointegrated devices |
| dc.title.none.fl_str_mv | Sandcastle Worm-Inspired Polyelectrolyte Hydrogel as a Bioadhesive for Diverse Tissues |
| dc.type.none.fl_str_mv | Dataset Media info:eu-repo/semantics/publishedVersion dataset |
| description | Bioadhesives have been widely applied in wound healing and hemostasis, as well as biointegrated devices. Most existing bioadhesives still lack fast adhesion formation, strong interfacial toughness, and outstanding compatibility in humidity environments. Here, we synthesized a polyampholyte hydrogel using oppositely charged acrylic acid and 2-(dimethylamino)ethyl methacrylate, inspired by the sandcastle worms. The anions and cations formed ionic bonds and endowed the hydrogel with outstanding mechanical properties, while the acrylic acids provided abundant carboxylic acid groups and created immediate physical cross-links with the wet tissue surface, allowing for fast and strong adhesion to various tissues and organs under physiological conditions. Moreover, the bioinspired hydrogels displayed outstanding <i>in vivo</i> and <i>in vitro</i> biocompatibility and degradability, significantly promoting wound healing and suppressing inflammation as a bioadhesive. The developed bioinspired polyelectrolyte hydrogel provides an avenue for wound care, as well as other potential medical applications. |
| eu_rights_str_mv | openAccess |
| id | Manara_4e21cc3c111d77692d06f446ad445aae |
| identifier_str_mv | 10.1021/acsapm.5c02092.s003 |
| network_acronym_str | Manara |
| network_name_str | ManaraRepo |
| oai_identifier_str | oai:figshare.com:article/30093126 |
| publishDate | 2025 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY-NC 4.0 |
| spelling | Sandcastle Worm-Inspired Polyelectrolyte Hydrogel as a Bioadhesive for Diverse TissuesJing Cong (519038)Xiaoming Liu (47653)Chengpan Li (10675845)Lin Mei (300443)Shaoshan Pan (11147050)Jie Tian (20496)Tianyu Xu (6794144)Chunguang Miao (4379080)Weiping Ding (721500)Tianzhi Luo (1460182)BiophysicsBiochemistryMedicineMolecular BiologyBiotechnologyDevelopmental BiologyCancerSpace ScienceBiological Sciences not elsewhere classifiedChemical Sciences not elsewhere classifiedPhysical Sciences not elsewhere classifiedwet tissue surfacepotential medical applications2 -( dimethylaminostrong interfacial toughnessoutstanding mechanical propertiesdiverse tissues bioadhesivesinspired polyelectrolyte hydrogelvarious tissuesstrong adhesionoutstanding compatibilitywound healingwound carewidely appliedvivo </vitro </suppressing inflammationsandcastle wormssandcastle wormphysiological conditionshumidity environmentsethyl methacrylatebiointegrated devicesBioadhesives have been widely applied in wound healing and hemostasis, as well as biointegrated devices. Most existing bioadhesives still lack fast adhesion formation, strong interfacial toughness, and outstanding compatibility in humidity environments. Here, we synthesized a polyampholyte hydrogel using oppositely charged acrylic acid and 2-(dimethylamino)ethyl methacrylate, inspired by the sandcastle worms. The anions and cations formed ionic bonds and endowed the hydrogel with outstanding mechanical properties, while the acrylic acids provided abundant carboxylic acid groups and created immediate physical cross-links with the wet tissue surface, allowing for fast and strong adhesion to various tissues and organs under physiological conditions. Moreover, the bioinspired hydrogels displayed outstanding <i>in vivo</i> and <i>in vitro</i> biocompatibility and degradability, significantly promoting wound healing and suppressing inflammation as a bioadhesive. The developed bioinspired polyelectrolyte hydrogel provides an avenue for wound care, as well as other potential medical applications.2025-09-10T06:30:15ZDatasetMediainfo:eu-repo/semantics/publishedVersiondataset10.1021/acsapm.5c02092.s003https://figshare.com/articles/media/Sandcastle_Worm-Inspired_Polyelectrolyte_Hydrogel_as_a_Bioadhesive_for_Diverse_Tissues/30093126CC BY-NC 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/300931262025-09-10T06:30:15Z |
| spellingShingle | Sandcastle Worm-Inspired Polyelectrolyte Hydrogel as a Bioadhesive for Diverse Tissues Jing Cong (519038) Biophysics Biochemistry Medicine Molecular Biology Biotechnology Developmental Biology Cancer Space Science Biological Sciences not elsewhere classified Chemical Sciences not elsewhere classified Physical Sciences not elsewhere classified wet tissue surface potential medical applications 2 -( dimethylamino strong interfacial toughness outstanding mechanical properties diverse tissues bioadhesives inspired polyelectrolyte hydrogel various tissues strong adhesion outstanding compatibility wound healing wound care widely applied vivo </ vitro </ suppressing inflammation sandcastle worms sandcastle worm physiological conditions humidity environments ethyl methacrylate biointegrated devices |
| status_str | publishedVersion |
| title | Sandcastle Worm-Inspired Polyelectrolyte Hydrogel as a Bioadhesive for Diverse Tissues |
| title_full | Sandcastle Worm-Inspired Polyelectrolyte Hydrogel as a Bioadhesive for Diverse Tissues |
| title_fullStr | Sandcastle Worm-Inspired Polyelectrolyte Hydrogel as a Bioadhesive for Diverse Tissues |
| title_full_unstemmed | Sandcastle Worm-Inspired Polyelectrolyte Hydrogel as a Bioadhesive for Diverse Tissues |
| title_short | Sandcastle Worm-Inspired Polyelectrolyte Hydrogel as a Bioadhesive for Diverse Tissues |
| title_sort | Sandcastle Worm-Inspired Polyelectrolyte Hydrogel as a Bioadhesive for Diverse Tissues |
| topic | Biophysics Biochemistry Medicine Molecular Biology Biotechnology Developmental Biology Cancer Space Science Biological Sciences not elsewhere classified Chemical Sciences not elsewhere classified Physical Sciences not elsewhere classified wet tissue surface potential medical applications 2 -( dimethylamino strong interfacial toughness outstanding mechanical properties diverse tissues bioadhesives inspired polyelectrolyte hydrogel various tissues strong adhesion outstanding compatibility wound healing wound care widely applied vivo </ vitro </ suppressing inflammation sandcastle worms sandcastle worm physiological conditions humidity environments ethyl methacrylate biointegrated devices |