Timeline of therapeutic strategies in type 1 diabetes illustrating past, current, and emerging interventions.
<p>Historically, the clinical strategy has been metabolic management focused exclusively on exogenous insulin replacement to correct its absence after destruction of beta cells. Advances in the field have led to optimized glycemic control through advanced insulin formulations, continuous gluco...
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2025
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| _version_ | 1849927628418449408 |
|---|---|
| author | Guy I. Sydney (22683459) |
| author2 | Ana Luisa Perdigoto (12210554) Kevan C. Herold (8860696) |
| author2_role | author author |
| author_facet | Guy I. Sydney (22683459) Ana Luisa Perdigoto (12210554) Kevan C. Herold (8860696) |
| author_role | author |
| dc.creator.none.fl_str_mv | Guy I. Sydney (22683459) Ana Luisa Perdigoto (12210554) Kevan C. Herold (8860696) |
| dc.date.none.fl_str_mv | 2025-11-25T18:29:49Z |
| dc.identifier.none.fl_str_mv | 10.1371/journal.pmed.1004813.g001 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/figure/Timeline_of_therapeutic_strategies_in_type_1_diabetes_illustrating_past_current_and_emerging_interventions_/30713949 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Molecular Biology Biotechnology Science Policy Virology Biological Sciences not elsewhere classified Chemical Sciences not elsewhere classified Information Systems not elsewhere classified type 1 diabetes towards insulin independence cure </ p |
| dc.title.none.fl_str_mv | Timeline of therapeutic strategies in type 1 diabetes illustrating past, current, and emerging interventions. |
| dc.type.none.fl_str_mv | Image Figure info:eu-repo/semantics/publishedVersion image |
| description | <p>Historically, the clinical strategy has been metabolic management focused exclusively on exogenous insulin replacement to correct its absence after destruction of beta cells. Advances in the field have led to optimized glycemic control through advanced insulin formulations, continuous glucose monitoring, and automated delivery systems. Beginning in the 1980s, immunomodulatory therapies began testing, aimed at preventing or slowing the loss of beta cell function after clinical diagnosis. With the recognition that the pathogenesis occurs over years and that prediction of disease is possible, the delay in diagnosis in those at risk led to its approval in 2022. Emerging strategies include beta cell replacement, with genetic modifications of the transplanted cells, potentially in combination with a brief immune treatment, to avoid the need for chronic immune suppression, or even induction of beta cell regeneration. The long-term goal, which would require expansion of screening to the general population and the enhancement of rates and duration of responses, is to arrest disease before its presentation, as exemplified by teplizumab. Figure created in Biorender. Sydney, G. (2025) <a href="http://BioRender.com/ywgcezg" target="_blank">http://BioRender.com/ywgcezg</a>.</p> |
| eu_rights_str_mv | openAccess |
| id | Manara_4e824da3234419ef805559e7f79d0c4b |
| identifier_str_mv | 10.1371/journal.pmed.1004813.g001 |
| network_acronym_str | Manara |
| network_name_str | ManaraRepo |
| oai_identifier_str | oai:figshare.com:article/30713949 |
| publishDate | 2025 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | Timeline of therapeutic strategies in type 1 diabetes illustrating past, current, and emerging interventions.Guy I. Sydney (22683459)Ana Luisa Perdigoto (12210554)Kevan C. Herold (8860696)Molecular BiologyBiotechnologyScience PolicyVirologyBiological Sciences not elsewhere classifiedChemical Sciences not elsewhere classifiedInformation Systems not elsewhere classifiedtype 1 diabetestowards insulin independencecure </ p<p>Historically, the clinical strategy has been metabolic management focused exclusively on exogenous insulin replacement to correct its absence after destruction of beta cells. Advances in the field have led to optimized glycemic control through advanced insulin formulations, continuous glucose monitoring, and automated delivery systems. Beginning in the 1980s, immunomodulatory therapies began testing, aimed at preventing or slowing the loss of beta cell function after clinical diagnosis. With the recognition that the pathogenesis occurs over years and that prediction of disease is possible, the delay in diagnosis in those at risk led to its approval in 2022. Emerging strategies include beta cell replacement, with genetic modifications of the transplanted cells, potentially in combination with a brief immune treatment, to avoid the need for chronic immune suppression, or even induction of beta cell regeneration. The long-term goal, which would require expansion of screening to the general population and the enhancement of rates and duration of responses, is to arrest disease before its presentation, as exemplified by teplizumab. Figure created in Biorender. Sydney, G. (2025) <a href="http://BioRender.com/ywgcezg" target="_blank">http://BioRender.com/ywgcezg</a>.</p>2025-11-25T18:29:49ZImageFigureinfo:eu-repo/semantics/publishedVersionimage10.1371/journal.pmed.1004813.g001https://figshare.com/articles/figure/Timeline_of_therapeutic_strategies_in_type_1_diabetes_illustrating_past_current_and_emerging_interventions_/30713949CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/307139492025-11-25T18:29:49Z |
| spellingShingle | Timeline of therapeutic strategies in type 1 diabetes illustrating past, current, and emerging interventions. Guy I. Sydney (22683459) Molecular Biology Biotechnology Science Policy Virology Biological Sciences not elsewhere classified Chemical Sciences not elsewhere classified Information Systems not elsewhere classified type 1 diabetes towards insulin independence cure </ p |
| status_str | publishedVersion |
| title | Timeline of therapeutic strategies in type 1 diabetes illustrating past, current, and emerging interventions. |
| title_full | Timeline of therapeutic strategies in type 1 diabetes illustrating past, current, and emerging interventions. |
| title_fullStr | Timeline of therapeutic strategies in type 1 diabetes illustrating past, current, and emerging interventions. |
| title_full_unstemmed | Timeline of therapeutic strategies in type 1 diabetes illustrating past, current, and emerging interventions. |
| title_short | Timeline of therapeutic strategies in type 1 diabetes illustrating past, current, and emerging interventions. |
| title_sort | Timeline of therapeutic strategies in type 1 diabetes illustrating past, current, and emerging interventions. |
| topic | Molecular Biology Biotechnology Science Policy Virology Biological Sciences not elsewhere classified Chemical Sciences not elsewhere classified Information Systems not elsewhere classified type 1 diabetes towards insulin independence cure </ p |