FIS1 and MiD49 as the adaptors of DRP1 mediates PRRSV-induced mitochondrial fission.

<p>(A-B) Marc-145 cells were transfected with control siRNA or siRNA targeting FIS1 (A) or MiD49 (B) for 24 h, and then were either mock-infected or infected with PRRSV (0.1 MOI) for an additional 24 h. The cells were stained with MitoTracker Red, PRRSV-N antibody, and DAPI, followed by confoc...

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Main Author:	Zhe Sun (328682) (author)
Other Authors:	Zicheng Ma (14071216) (author), Wandi Cao (20553288) (author), Chenlong Jiang (14071219) (author), Lei Guo (36221) (author), Kesen Liu (9086343) (author), Yanni Gao (6250973) (author), Juan Bai (798838) (author), Jiang Pi (817619) (author), Ping Jiang (243020) (author), Xing Liu (221084) (author)
Published:	2025
Subjects:	Biophysics Biochemistry Cell Biology Genetics Molecular Biology Neuroscience Physiology Cancer Science Policy Infectious Diseases Plant Biology Virology Environmental Sciences not elsewhere classified “ powerhouse ” providing new insights promoting cellular glycolysis mams ), mediated ip3r )— voltage generating cellular energy excessive lactate production camkkβ )— amp ampk )— dynamin activated protein kinase regulates mitochondrial function mitochondrial dynamics proteins hijack mitochondrial function promote mitochondrial fission mediated mitochondrial fission induced mitochondrial fission induce mitochondrial fission alongside mitochondrial fission related protein 1 triggers mitophagy via mitophagy drive glycolysis respiratory syndrome virus div >< p 2 +</ sup elevated mitochondria ca mitochondrial ca inositol 1 elevated levels vital role upregulated expression triphosphate receptor study reveals sigmar1 ). sigma non mitochondria ca increased mitochondria evolved mechanisms endoplasmic reticulum dynamic processes 49 kda
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FIS1 and MiD49 as the adaptors of DRP1 mediates PRRSV-induced mitochondrial fission.

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