Dentate granule cells have polarised responses to neuromodulators switch spiking behaviour under neuromodulation.
<p><b>A:</b> In control conditions, DGCs strongly adapt their firing. <b>B:</b> Acetylcholine (ACh) increasingly reduces inter-spike-interval (ISI) and abolishes spike adaptation. <b>C:</b> Histamine (HT) reduces spike adaptation but leaves ISI close to cont...
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2025
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| _version_ | 1852014359811719168 |
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| author | Domenico Guarino (20428000) |
| author2 | Ilaria Carannante (12526456) Alain Destexhe (259217) |
| author2_role | author author |
| author_facet | Domenico Guarino (20428000) Ilaria Carannante (12526456) Alain Destexhe (259217) |
| author_role | author |
| dc.creator.none.fl_str_mv | Domenico Guarino (20428000) Ilaria Carannante (12526456) Alain Destexhe (259217) |
| dc.date.none.fl_str_mv | 2025-12-01T18:52:24Z |
| dc.identifier.none.fl_str_mv | 10.1371/journal.pcbi.1013765.g004 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/figure/Dentate_granule_cells_have_polarised_responses_to_neuromodulators_switch_spiking_behaviour_under_neuromodulation_/30756186 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Genetics Neuroscience Evolutionary Biology Science Policy Biological Sciences not elsewhere classified yet biologically accurate electrophysiological properties induced dimensionality reduction technique adaptive exponential integrate switching &# 8221 scaling &# 8221 analyse electrophysiological data xlink "> first different neuromodulators remap brain </ p altering neuronal excitability xlink "> excitability landscape data using &# 8220 &# 8211 still lack source python seven types readily applicable published papers parameters space parameter space overlapping clusters offering experimenters neuronal activity neuromodulated conditions much work integrative perspective five neuromodulators five areas fire model extract features existing behaviour dynamical regimes compact description cohesive picture based workflow another species analyses revealed adex ). |
| dc.title.none.fl_str_mv | Dentate granule cells have polarised responses to neuromodulators switch spiking behaviour under neuromodulation. |
| dc.type.none.fl_str_mv | Image Figure info:eu-repo/semantics/publishedVersion image |
| description | <p><b>A:</b> In control conditions, DGCs strongly adapt their firing. <b>B:</b> Acetylcholine (ACh) increasingly reduces inter-spike-interval (ISI) and abolishes spike adaptation. <b>C:</b> Histamine (HT) reduces spike adaptation but leaves ISI close to control conditions. <b>D:</b> Norepinephrine (NA) has effects of reduced spike adaptation and ISI similar to ACh. <b>E:</b> In the PCA-reduced parameter space, the control (red) and modulated clusters were distinct (Silhouette score ). HT cluster (light green) presents the largest variation along both Principal Component axes, and NA and ACh have similar variations. The parameters most influencing PC1 are related to subthreshold and adaptation properties [Delta_T, b, tau_w], while PC2 is primarily shaped by spiking threshold and reset dynamics [V_th, V_peak, V_reset]. <b>F:</b> All neuromodulators caused a switch in the excitability landscape, shifting the ratio <i>a</i>/<i>g</i><sub><i>L</i></sub> downward and moving the cells from Class II to Class I excitability. Small circles: individual fits; filled symbols with black arrows: condition means and mean Control→Modulated displacement. Dashed line: Bogdanov–Takens boundary. In the inset phase spaces, we have the <i>V</i> (solid) and <i>w</i> (dashed) nullclines, with their intersection representing fixed points. With respect to control (orange), all neuromodulators, except ACh, increase the excitability of the neuron by lowering the slope of the <i>V</i>-nullcline left branch and raising the vertical position (in <i>w</i>) of the <i>V</i>-nullcline vertex. While HT (dark green) and NA (blue) reduce the adaptation rate (lowering the <i>w</i>-nullcline slope), ACh increasingly removes adaptation (captured by the negative <i>w</i> slope) and also lowers the vertex of the <i>V</i>-nullcline.</p> |
| eu_rights_str_mv | openAccess |
| id | Manara_4ea545bad5d63e57ce8e2a894bc062c1 |
| identifier_str_mv | 10.1371/journal.pcbi.1013765.g004 |
| network_acronym_str | Manara |
| network_name_str | ManaraRepo |
| oai_identifier_str | oai:figshare.com:article/30756186 |
| publishDate | 2025 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | Dentate granule cells have polarised responses to neuromodulators switch spiking behaviour under neuromodulation.Domenico Guarino (20428000)Ilaria Carannante (12526456)Alain Destexhe (259217)GeneticsNeuroscienceEvolutionary BiologyScience PolicyBiological Sciences not elsewhere classifiedyet biologically accurateelectrophysiological properties induceddimensionality reduction techniqueadaptive exponential integrateswitching &# 8221scaling &# 8221analyse electrophysiological dataxlink "> firstdifferent neuromodulators remapbrain </ paltering neuronal excitabilityxlink ">excitability landscapedata using&# 8220&# 8211still lacksource pythonseven typesreadily applicablepublished papersparameters spaceparameter spaceoverlapping clustersoffering experimentersneuronal activityneuromodulated conditionsmuch workintegrative perspectivefive neuromodulatorsfive areasfire modelextract featuresexisting behaviourdynamical regimescompact descriptioncohesive picturebased workflowanother speciesanalyses revealedadex ).<p><b>A:</b> In control conditions, DGCs strongly adapt their firing. <b>B:</b> Acetylcholine (ACh) increasingly reduces inter-spike-interval (ISI) and abolishes spike adaptation. <b>C:</b> Histamine (HT) reduces spike adaptation but leaves ISI close to control conditions. <b>D:</b> Norepinephrine (NA) has effects of reduced spike adaptation and ISI similar to ACh. <b>E:</b> In the PCA-reduced parameter space, the control (red) and modulated clusters were distinct (Silhouette score ). HT cluster (light green) presents the largest variation along both Principal Component axes, and NA and ACh have similar variations. The parameters most influencing PC1 are related to subthreshold and adaptation properties [Delta_T, b, tau_w], while PC2 is primarily shaped by spiking threshold and reset dynamics [V_th, V_peak, V_reset]. <b>F:</b> All neuromodulators caused a switch in the excitability landscape, shifting the ratio <i>a</i>/<i>g</i><sub><i>L</i></sub> downward and moving the cells from Class II to Class I excitability. Small circles: individual fits; filled symbols with black arrows: condition means and mean Control→Modulated displacement. Dashed line: Bogdanov–Takens boundary. In the inset phase spaces, we have the <i>V</i> (solid) and <i>w</i> (dashed) nullclines, with their intersection representing fixed points. With respect to control (orange), all neuromodulators, except ACh, increase the excitability of the neuron by lowering the slope of the <i>V</i>-nullcline left branch and raising the vertical position (in <i>w</i>) of the <i>V</i>-nullcline vertex. While HT (dark green) and NA (blue) reduce the adaptation rate (lowering the <i>w</i>-nullcline slope), ACh increasingly removes adaptation (captured by the negative <i>w</i> slope) and also lowers the vertex of the <i>V</i>-nullcline.</p>2025-12-01T18:52:24ZImageFigureinfo:eu-repo/semantics/publishedVersionimage10.1371/journal.pcbi.1013765.g004https://figshare.com/articles/figure/Dentate_granule_cells_have_polarised_responses_to_neuromodulators_switch_spiking_behaviour_under_neuromodulation_/30756186CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/307561862025-12-01T18:52:24Z |
| spellingShingle | Dentate granule cells have polarised responses to neuromodulators switch spiking behaviour under neuromodulation. Domenico Guarino (20428000) Genetics Neuroscience Evolutionary Biology Science Policy Biological Sciences not elsewhere classified yet biologically accurate electrophysiological properties induced dimensionality reduction technique adaptive exponential integrate switching &# 8221 scaling &# 8221 analyse electrophysiological data xlink "> first different neuromodulators remap brain </ p altering neuronal excitability xlink "> excitability landscape data using &# 8220 &# 8211 still lack source python seven types readily applicable published papers parameters space parameter space overlapping clusters offering experimenters neuronal activity neuromodulated conditions much work integrative perspective five neuromodulators five areas fire model extract features existing behaviour dynamical regimes compact description cohesive picture based workflow another species analyses revealed adex ). |
| status_str | publishedVersion |
| title | Dentate granule cells have polarised responses to neuromodulators switch spiking behaviour under neuromodulation. |
| title_full | Dentate granule cells have polarised responses to neuromodulators switch spiking behaviour under neuromodulation. |
| title_fullStr | Dentate granule cells have polarised responses to neuromodulators switch spiking behaviour under neuromodulation. |
| title_full_unstemmed | Dentate granule cells have polarised responses to neuromodulators switch spiking behaviour under neuromodulation. |
| title_short | Dentate granule cells have polarised responses to neuromodulators switch spiking behaviour under neuromodulation. |
| title_sort | Dentate granule cells have polarised responses to neuromodulators switch spiking behaviour under neuromodulation. |
| topic | Genetics Neuroscience Evolutionary Biology Science Policy Biological Sciences not elsewhere classified yet biologically accurate electrophysiological properties induced dimensionality reduction technique adaptive exponential integrate switching &# 8221 scaling &# 8221 analyse electrophysiological data xlink "> first different neuromodulators remap brain </ p altering neuronal excitability xlink "> excitability landscape data using &# 8220 &# 8211 still lack source python seven types readily applicable published papers parameters space parameter space overlapping clusters offering experimenters neuronal activity neuromodulated conditions much work integrative perspective five neuromodulators five areas fire model extract features existing behaviour dynamical regimes compact description cohesive picture based workflow another species analyses revealed adex ). |