Dentate granule cells have polarised responses to neuromodulators switch spiking behaviour under neuromodulation.

A: In control conditions, DGCs strongly adapt their firing. B: Acetylcholine (ACh) increasingly reduces inter-spike-interval (ISI) and abolishes spike adaptation. C: Histamine (HT) reduces spike adaptation but leaves ISI close to cont...

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Bibliographic Details
Main Author:	Domenico Guarino (20428000) (author)
Other Authors:	Ilaria Carannante (12526456) (author), Alain Destexhe (259217) (author)
Published:	2025
Subjects:	Genetics Neuroscience Evolutionary Biology Science Policy Biological Sciences not elsewhere classified yet biologically accurate electrophysiological properties induced dimensionality reduction technique adaptive exponential integrate switching &# 8221 scaling &# 8221 analyse electrophysiological data xlink "> first different neuromodulators remap brain </ p altering neuronal excitability xlink "> excitability landscape data using &# 8220 &# 8211 still lack source python seven types readily applicable published papers parameters space parameter space overlapping clusters offering experimenters neuronal activity neuromodulated conditions much work integrative perspective five neuromodulators five areas fire model extract features existing behaviour dynamical regimes compact description cohesive picture based workflow another species analyses revealed adex ).
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Dentate granule cells have polarised responses to neuromodulators switch spiking behaviour under neuromodulation.

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