Flow chart for the study selection.

<div><p>Introduction</p><p>In Latin America and the Caribbean (LAC) the response to substance use has primarily been abstinence-based, acute-care-oriented treatments. While harm reduction services (HRS) and interventions have expanded in LAC over the last decade, the research...

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Prif Awdur: Ignacio Bórquez (22477946) (author)
Awduron Eraill: Katie Bailey (16220075) (author), Gregory Laynor (18176888) (author), Lidiane Toledo (22676403) (author), Francisco I. Bastos (8438016) (author), Julian Santaella-Tenorio (4836492) (author), Álvaro Castillo-Carniglia (22374551) (author), Magdalena Cerdá (471406) (author), Noa Krawczyk (528106) (author)
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_version_ 1849927643293548544
author Ignacio Bórquez (22477946)
author2 Katie Bailey (16220075)
Gregory Laynor (18176888)
Lidiane Toledo (22676403)
Francisco I. Bastos (8438016)
Julian Santaella-Tenorio (4836492)
Álvaro Castillo-Carniglia (22374551)
Magdalena Cerdá (471406)
Noa Krawczyk (528106)
author2_role author
author
author
author
author
author
author
author
author_facet Ignacio Bórquez (22477946)
Katie Bailey (16220075)
Gregory Laynor (18176888)
Lidiane Toledo (22676403)
Francisco I. Bastos (8438016)
Julian Santaella-Tenorio (4836492)
Álvaro Castillo-Carniglia (22374551)
Magdalena Cerdá (471406)
Noa Krawczyk (528106)
author_role author
dc.creator.none.fl_str_mv Ignacio Bórquez (22477946)
Katie Bailey (16220075)
Gregory Laynor (18176888)
Lidiane Toledo (22676403)
Francisco I. Bastos (8438016)
Julian Santaella-Tenorio (4836492)
Álvaro Castillo-Carniglia (22374551)
Magdalena Cerdá (471406)
Noa Krawczyk (528106)
dc.date.none.fl_str_mv 2025-11-24T18:24:48Z
dc.identifier.none.fl_str_mv 10.1371/journal.pone.0334978.g001
dc.relation.none.fl_str_mv https://figshare.com/articles/figure/Flow_chart_for_the_study_selection_/30696681
dc.rights.none.fl_str_mv CC BY 4.0
info:eu-repo/semantics/openAccess
dc.subject.none.fl_str_mv Medicine
Biotechnology
Cancer
Science Policy
Mental Health
Infectious Diseases
Virology
substance &# 160
safer consumption kits
opioid agonist therapy
2013 &# 8211
unveil services needed
managed alcohol programs
harm reduction services
narrative synthesis approach
drug consumption facilities
conduct literature searches
proposed scoping review
first scoping review
syringe services programs
science ), spanish
reviewed original research
scoping review
systematic approach
reviewed literature
narrative summary
january 2013
bireme ),
evaluating services
checking services
xlink ">
two reviewers
synthesize gaps
summarize implications
studies using
research evidence
qya7c /</
oriented treatments
methods designs
map peer
latin america
last decade
independently screen
including qualitative
current state
consider peer
broad number
bireme ).
dc.title.none.fl_str_mv Flow chart for the study selection.
dc.type.none.fl_str_mv Image
Figure
info:eu-repo/semantics/publishedVersion
image
description <div><p>Introduction</p><p>In Latin America and the Caribbean (LAC) the response to substance use has primarily been abstinence-based, acute-care-oriented treatments. While harm reduction services (HRS) and interventions have expanded in LAC over the last decade, the research evidence on such programs has been sparse and disjointed.</p><p>Objective</p><p>This scoping review will map peer-reviewed literature on HRS and interventions in LAC, and synthesize gaps and opportunities for policy, practice, and research.</p><p>Inclusion criteria</p><p>Studies conducted in LAC. The HRS that will be included in the search are opioid agonist therapy, syringe services programs, drug consumption facilities, safer consumption kits, managed alcohol programs, and drug-checking services. The scoping review will consider peer-reviewed original research, including qualitative, quantitative, and mixed-methods designs. We will exclude studies addressing harms associated with nicotine or tobacco use. We included original research written in English, Spanish, Portuguese, or French published between January 2013 and December 2024.</p><p>Methods</p><p>We will conduct literature searches in English (PubMed, Scopus, Web of Science), Spanish, Portuguese (SciELO and BIREME), and French (BIREME). Two reviewers will independently screen the literature. Extraction of characteristics of the studies using a template in Covidence. Data on the HRS and interventions studied and implemented in LAC will be summarized and presented in tables, graphs, and a narrative summary. We will use a narrative synthesis approach to summarize implications for policy, research, and practice identified in the literature. The review was registered in Open Science Framework (<a href="https://osf.io/qya7c/" target="_blank">https://osf.io/qya7c/</a>),</p><p>Discussion</p><p>The proposed scoping review will provide valuable information regarding the current state of HRS and interventions for PWUD in LAC. This in return can help guide future research for evaluating services that are already being implemented or unveil services needed in the region. To our knowledge, this is the first scoping review to map HRS in LAC using a systematic approach. Furthermore, among the strengths of this review are: the broad number of services, countries, and time, as well as the consultation with experts and knowledge users.</p></div>
eu_rights_str_mv openAccess
id Manara_50e2ac8f74fbd95e86fd987f3a3be723
identifier_str_mv 10.1371/journal.pone.0334978.g001
network_acronym_str Manara
network_name_str ManaraRepo
oai_identifier_str oai:figshare.com:article/30696681
publishDate 2025
repository.mail.fl_str_mv
repository.name.fl_str_mv
repository_id_str
rights_invalid_str_mv CC BY 4.0
spelling Flow chart for the study selection.Ignacio Bórquez (22477946)Katie Bailey (16220075)Gregory Laynor (18176888)Lidiane Toledo (22676403)Francisco I. Bastos (8438016)Julian Santaella-Tenorio (4836492)Álvaro Castillo-Carniglia (22374551)Magdalena Cerdá (471406)Noa Krawczyk (528106)MedicineBiotechnologyCancerScience PolicyMental HealthInfectious DiseasesVirologysubstance &# 160safer consumption kitsopioid agonist therapy2013 &# 8211unveil services neededmanaged alcohol programsharm reduction servicesnarrative synthesis approachdrug consumption facilitiesconduct literature searchesproposed scoping reviewfirst scoping reviewsyringe services programsscience ), spanishreviewed original researchscoping reviewsystematic approachreviewed literaturenarrative summaryjanuary 2013bireme ),evaluating serviceschecking servicesxlink ">two reviewerssynthesize gapssummarize implicationsstudies usingresearch evidenceqya7c /</oriented treatmentsmethods designsmap peerlatin americalast decadeindependently screenincluding qualitativecurrent stateconsider peerbroad numberbireme ).<div><p>Introduction</p><p>In Latin America and the Caribbean (LAC) the response to substance use has primarily been abstinence-based, acute-care-oriented treatments. While harm reduction services (HRS) and interventions have expanded in LAC over the last decade, the research evidence on such programs has been sparse and disjointed.</p><p>Objective</p><p>This scoping review will map peer-reviewed literature on HRS and interventions in LAC, and synthesize gaps and opportunities for policy, practice, and research.</p><p>Inclusion criteria</p><p>Studies conducted in LAC. The HRS that will be included in the search are opioid agonist therapy, syringe services programs, drug consumption facilities, safer consumption kits, managed alcohol programs, and drug-checking services. The scoping review will consider peer-reviewed original research, including qualitative, quantitative, and mixed-methods designs. We will exclude studies addressing harms associated with nicotine or tobacco use. We included original research written in English, Spanish, Portuguese, or French published between January 2013 and December 2024.</p><p>Methods</p><p>We will conduct literature searches in English (PubMed, Scopus, Web of Science), Spanish, Portuguese (SciELO and BIREME), and French (BIREME). Two reviewers will independently screen the literature. Extraction of characteristics of the studies using a template in Covidence. Data on the HRS and interventions studied and implemented in LAC will be summarized and presented in tables, graphs, and a narrative summary. We will use a narrative synthesis approach to summarize implications for policy, research, and practice identified in the literature. The review was registered in Open Science Framework (<a href="https://osf.io/qya7c/" target="_blank">https://osf.io/qya7c/</a>),</p><p>Discussion</p><p>The proposed scoping review will provide valuable information regarding the current state of HRS and interventions for PWUD in LAC. This in return can help guide future research for evaluating services that are already being implemented or unveil services needed in the region. To our knowledge, this is the first scoping review to map HRS in LAC using a systematic approach. Furthermore, among the strengths of this review are: the broad number of services, countries, and time, as well as the consultation with experts and knowledge users.</p></div>2025-11-24T18:24:48ZImageFigureinfo:eu-repo/semantics/publishedVersionimage10.1371/journal.pone.0334978.g001https://figshare.com/articles/figure/Flow_chart_for_the_study_selection_/30696681CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/306966812025-11-24T18:24:48Z
spellingShingle Flow chart for the study selection.
Ignacio Bórquez (22477946)
Medicine
Biotechnology
Cancer
Science Policy
Mental Health
Infectious Diseases
Virology
substance &# 160
safer consumption kits
opioid agonist therapy
2013 &# 8211
unveil services needed
managed alcohol programs
harm reduction services
narrative synthesis approach
drug consumption facilities
conduct literature searches
proposed scoping review
first scoping review
syringe services programs
science ), spanish
reviewed original research
scoping review
systematic approach
reviewed literature
narrative summary
january 2013
bireme ),
evaluating services
checking services
xlink ">
two reviewers
synthesize gaps
summarize implications
studies using
research evidence
qya7c /</
oriented treatments
methods designs
map peer
latin america
last decade
independently screen
including qualitative
current state
consider peer
broad number
bireme ).
status_str publishedVersion
title Flow chart for the study selection.
title_full Flow chart for the study selection.
title_fullStr Flow chart for the study selection.
title_full_unstemmed Flow chart for the study selection.
title_short Flow chart for the study selection.
title_sort Flow chart for the study selection.
topic Medicine
Biotechnology
Cancer
Science Policy
Mental Health
Infectious Diseases
Virology
substance &# 160
safer consumption kits
opioid agonist therapy
2013 &# 8211
unveil services needed
managed alcohol programs
harm reduction services
narrative synthesis approach
drug consumption facilities
conduct literature searches
proposed scoping review
first scoping review
syringe services programs
science ), spanish
reviewed original research
scoping review
systematic approach
reviewed literature
narrative summary
january 2013
bireme ),
evaluating services
checking services
xlink ">
two reviewers
synthesize gaps
summarize implications
studies using
research evidence
qya7c /</
oriented treatments
methods designs
map peer
latin america
last decade
independently screen
including qualitative
current state
consider peer
broad number
bireme ).