<b>Structural Determinants of Non-Covalent PPARγ Inverse Agonism and Their Therapeutic Implications</b>

<b>Structural Determinants of Non-Covalent PPARγ Inverse Agonism and Their Therapeutic Implications</b>

<p dir="ltr">Peroxisome proliferator-activated receptor gamma (PPARγ) is a validated therapeutic target for type 2 diabetes (T2D), but current FDA-approved agonists are limited by adverse effects. SR10171, a non-covalent partial inverse agonist with modest binding potency, improves i...

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主要作者:	Kuang-Ting Kuo (21682520) (author)
其他作者:	Patrick R. Griffin (16519783) (author)
出版:	2025
主題:	Biochemistry and cell biology not elsewhere classified Structural dynamics Pparg2 HDx analysis compound screening strategy adipocyte AlphaScreen LanthaScreen Gal4-UAS 3T3-L1 adipocyte differentiation Adipogenesis Insulin sensitizer molecular & dynamics docking
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