Interaction between MBMATCs and the immune microenvironment.

<p>(A) Scatter plot depicting the outgoing and incoming interaction strength for each cell subpopulation within PTs, ECMs and MBMs. (B) Dot plot showing ligand-receptor interactions from specified subpopulations (Mela3, CD8-LEF1, CD8-NKG7, CD8-HIF1A) to the CD8-HAVCR2 subpopulation across PTs,...

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Autore principale:	Jingxin Zeng (18773484) (author)
Altri autori:	Ling Lin (57361) (author), Yangyang Ma (6329852) (author), Wenzhe Huang (446343) (author), Quan Luo (1423180) (author), Ju Wen (14784239) (author)
Pubblicazione:	2025
Soggetti:	Cell Biology Genetics Neuroscience Biotechnology Immunology Developmental Biology Cancer Hematology Virology Biological Sciences not elsewhere classified Information Systems not elsewhere classified limited treatment efficacy associated tumor cells adhesion genes (< nucleus rna sequencing metastatic tumor subpopulation 26 melanoma samples study identifies mbmatcs mbm ecosystems showed div >< p melanoma brain metastasis metastatic pathways bulk rna brain metastasis melanoma patients validation cohorts upregulated neural treg enrichment remains lethal potential activity nrg3 </ ncam1 </ mela3 ). lag3 </ high risk havcr2 </ early stratification clinical relevance cellular origins cellular origin brain tropism >), suggesting 1 </
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Riassunto:	<p>(A) Scatter plot depicting the outgoing and incoming interaction strength for each cell subpopulation within PTs, ECMs and MBMs. (B) Dot plot showing ligand-receptor interactions from specified subpopulations (Mela3, CD8-LEF1, CD8-NKG7, CD8-HIF1A) to the CD8-HAVCR2 subpopulation across PTs, ECMs, and MBMs. Dot size corresponds to the statistical significance (P-value), and color intensity represents the interaction strength.</p> <p>(TIF)</p>

Interaction between MBMATCs and the immune microenvironment.

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