Simulated serological data using serosim and subsequent results using the full mixture model on (a) HAI, (b) IgG and (c) IgM data with additional observational noise.

Simulated serological data using serosim and subsequent results using the full mixture model on (a) HAI, (b) IgG and (c) IgM data with additional observational noise.

<p>For each we present the predicted infection status using the mixture model approach along with the true underlying infection status. Parameters chosen for forward simulation are presented in <a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1013708#pcbi.1013...

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Tác giả chính:	Marco Hamins-Puértolas (15238661) (author)
Tác giả khác:	Darunee Buddhari (625855) (author), Henrik Salje (589157) (author), Angkana T. Huang (12262139) (author), Taweewun Hunsawong (798675) (author), Derek A.T. Cummings (14971341) (author), Stefan Fernandez (146590) (author), Aaron Farmer (4288318) (author), Surachai Kaewhiran (22683535) (author), Direk Khampaen (22683538) (author), Anon Srikiatkhachorn (110184) (author), Sopon Iamsirithaworn (260152) (author), Adam Waickman (118668) (author), Stephen J. Thomas (7105673) (author), Timothy Endy (150971) (author), Alan L. Rothman (6835178) (author), Kathryn B. Anderson (6835166) (author), Isabel Rodriguez-Barraquer (233670) (author)
Được phát hành:	2025
Những chủ đề:	Medicine Biotechnology Ecology Immunology Cancer Science Policy Infectious Diseases Virology Computational Biology Biological Sciences not elsewhere classified Mathematical Sciences not elsewhere classified Chemical Sciences not elsewhere classified since many cases linked immunosorbent assay independently utilize information hemagglutination inhibition assay globe &# 8217 currently implemented cut convalescent serum collected 87 &# 8211 82 &# 8211 real world data multiple serological assays infer infection events generate finalized interpretations bayesian mixture model prior standard interpretations pcr confirmed infections jointly model data gold standard ). f1 scores ). hai data consistently direct detection methods gold standard f1 scores infection detection eia ). including data individual assays new model igm data whether individuals transmission potential results provide recently experienced provide insight probabilistic framework population living point approaches pathogen systems kamphaeng phet interpreting results incorporating igg important role higher accuracy first test diagnostic process creating uncertainty combined metric already half 677 pairs
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Những quyển sách tương tự

Comparison between simulation based estimates for boosts in GM HAI, IgG, and IgM that is experienced after an infection event as a function of acute GM HAI, IgG, and IgM titers individuals under the varying levels of observational noise.
Bằng: Marco Hamins-Puértolas (15238661)
Được phát hành: (2025)

Parameters for forward simulation using serosim [38].
Bằng: Marco Hamins-Puértolas (15238661)
Được phát hành: (2025)

Distribution of paired serological data that fall into probability buckets when using Model 9 (incorporating paired IgG, IgM, GM HAI, and acute GM HAI serological data) and the number of serological assays (RT-PCR, HAI, and EIA) that interpret the individual as having an infection.
Bằng: Marco Hamins-Puértolas (15238661)
Được phát hành: (2025)

Acute and convalescent samples from cohort study data for serological assays, colored by the number of serological assays (RT-PCR, HAI, and EIA) that interpret the individual as having an infection. a) Geometric mean titers of a haemagglutination inhibition assay (GM HAI) for all four serotypes of dengue virus. b) Immunoglobulin G (IgG) c) Immunoglobulin M (IgM) d) Ratio of IgM to IgG at both acute and convalescent serum samples.
Bằng: Marco Hamins-Puértolas (15238661)
Được phát hành: (2025)

Acute and convalescent data for serological assays, colored by probability of infection found during model testing for Model 9. a) Geometric mean titers of a haemagglutination inhibition assay (GM HAI) for all four serotypes of dengue virus. b) Immunoglobulin G (IgG) c) Immunoglobulin M (IgM) d) Ratio of IgM to IgG at both acute and convalescent sera samples.
Bằng: Marco Hamins-Puértolas (15238661)
Được phát hành: (2025)

Relationship between estimated probability of a dengue virus infection (DENV) found during model testing for Model 9 (incorporating paired IgG, IgM, GM HAI, and acute GM HAI serological data) and the number of serological assays (RT-PCR, HAI, and EIA) that interpret the individual as having an infection.
Bằng: Marco Hamins-Puértolas (15238661)
Được phát hành: (2025)

Relative observational noise by assay and dataset.
Bằng: Marco Hamins-Puértolas (15238661)
Được phát hành: (2025)

Comparison of each accuracy metric (sensitivity, specificity, F1, and area under the curve for reporter operator curve (AUC ROC)) on each model. Models are defined by which assays were incorporated (i.e., HAI, IgG, and/or IgM). Bolded values represent the best performing model for the infection definition and metric of interest.
Bằng: Marco Hamins-Puértolas (15238661)
Được phát hành: (2025)

Model comparisons for simulated data with differing amounts of observational noise.
Bằng: Marco Hamins-Puértolas (15238661)
Được phát hành: (2025)

Comparison of accuracy metrics (sensitivity, specificity, and AUC ROC) of each model defined by what subset of data was used for training and testing.
Bằng: Marco Hamins-Puértolas (15238661)
Được phát hành: (2025)

Acute and convalescent samples from cohort study data for serological assays, colored by whether they are predicted as infections using Model 9.
Bằng: Marco Hamins-Puértolas (15238661)
Được phát hành: (2025)

Acute and convalescent serological data from Thai cohorts used in this analyses, colored by true infections status and prediction of infection during model testing.
Bằng: Marco Hamins-Puértolas (15238661)
Được phát hành: (2025)

Characteristics for Kamphaeng Phet cohort studies split by source (KPS1 and KFCS) as well as across the entire dataset. Information on age, hospitalization as well as serological assay results for RT-PCR, haemagglutination inhibition assay (HAI), and enzyme immunoassay (EIA) are presented.
Bằng: Marco Hamins-Puértolas (15238661)
Được phát hành: (2025)

Theoretical relationship between time since symptom onset and titers in one infected (red) and three uninfected (blue) individuals.
Bằng: Marco Hamins-Puértolas (15238661)
Được phát hành: (2025)

(A) Estimated intercept for titer boost when acute titers are initially low for each assay.
Bằng: Marco Hamins-Puértolas (15238661)
Được phát hành: (2025)

Parameters found in Bayesian estimation framework, definition, and prior distribution.
Bằng: Marco Hamins-Puértolas (15238661)
Được phát hành: (2025)

Acute and convalescent data for serological assays, colored by probability of.
Bằng: Marco Hamins-Puértolas (15238661)
Được phát hành: (2025)

A Four-Gene Signature from Blood to Exclude Bacterial Etiology of Lower Respiratory Tract Infection in Adults
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Được phát hành: (2025)

الترتيبات القانونية الخاصة بالنظام النقدي الدولي ومدى استجابتها لمصالح المجتمع الدولي
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Được phát hành: (2021)

Data Sheet 1_Whole genome sequencing as a reliable alternative for Salmonella serotyping: a comparative study with the gold-standard method.pdf
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Được phát hành: (2025)

Top-performing model configuration and performance by algorithm type.
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Được phát hành: (2025)

Comparison of baseline and hybrid machine learning models in predicting IVF outcomes (%).
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Được phát hành: (2025)

The list of parameters of the modified data set for machine learning (<i>n</i> = 162).
Bằng: Uğur Ejder (22683228)
Được phát hành: (2025)

The statistical description of the original data set of the patients (<i>n</i> = 162).
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Được phát hành: (2025)

Confusion matrix of the ABC–LR–RF hybrid model for IVF outcome prediction.
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Được phát hành: (2025)

ROC and PR–AUC curves of the ABC–LR–RF hybrid model for IVF outcome prediction.
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Được phát hành: (2025)

The most effective active substances for subfertility treatment.
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Được phát hành: (2025)

The comparison of the accuracy score of the benchmark and the proposed models.
Bằng: Uğur Ejder (22683228)
Được phát hành: (2025)

The prediction accuracy of simple versus hybrid models.
Bằng: Uğur Ejder (22683228)
Được phát hành: (2025)

The accuracy score change matrix following model development.
Bằng: Uğur Ejder (22683228)
Được phát hành: (2025)

Calibration curve of the ABC–LR–RF hybrid model for IVF outcome prediction.
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Được phát hành: (2025)

Flow diagram of the proposed model.
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Được phát hành: (2025)

Flow diagram of the conversion of drugs into active substances.
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Được phát hành: (2025)

Validation of ultrasound assessments across BMI groups using same-day ultrasound and radiography.
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Scoliosis assessment in this study: A) ultrasound scan using the Scolioscan® system; B) standard posteroanterior radiograph showing a Cobb angle of 25.6°; C) corresponding coronal ultrasound image showing a curvature angle of 26.9° using SP method.
Bằng: JoJo Yiying Zou (22676490)
Được phát hành: (2025)

<i>K. pneumoniae</i> genomes represented in amr.watch as of 31 March 2025, filtered by the presence of the carbapenem resistance gene, <i>bla</i><sub>NDM-5</sub>.
Bằng: Sophia David (4172902)
Được phát hành: (2025)

<i>K. pneumoniae</i> genomes represented in amr.watch as of 31 March 2025 from the USA (A) and China (B) filtered by the most frequent ST from each country (ST258 and ST11, respectively).
Bằng: Sophia David (4172902)
Được phát hành: (2025)

Proportion of genomes by year from the five critical-level priority pathogens carrying one or more AMR mechanisms for relevant antimicrobial classes, as displayed in the “AMR mechanism proportion over time” panel within amr.watch.
Bằng: Sophia David (4172902)
Được phát hành: (2025)

Distribution of pathogen genomes represented in amr.watch as of 31 March 2025.
Bằng: Sophia David (4172902)
Được phát hành: (2025)

The interactive amr.watch application here shows an overview from 179,518 <i>E. coli</i> genomes available as of 31 March 2025.
Bằng: Sophia David (4172902)
Được phát hành: (2025)

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