Phylogenomic analysis of NagS.
<p>Phylogenetic tree of NagS proteins in the StringDB database. The branches are annotated with the strain names in which the orthologues occur. <i>Streptomyces</i> and <i>Kitasatospora</i> strains are denoted by blue and green markers, respectively. NagS was exclusivel...
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2025
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| _version_ | 1849927625801203712 |
|---|---|
| author | Chao Li (145513) |
| author2 | Mia Urem (22683580) Ioli Kotsogianni (9930187) Josephine Lau (20442343) Chao Du (288036) Somayah S. Elsayed (9192571) Nathaniel I. Martin (847378) Iain W. McNae (840777) Patrick Voskamp (2311429) Christoph Mayer (57204) Sébastien Rigali (724082) Navraj Pannu (10163763) Jan Pieter Abrahams (1429531) Lennart Schada von Borzyskowski (22683583) Gilles P. van Wezel (7838948) |
| author2_role | author author author author author author author author author author author author author author |
| author_facet | Chao Li (145513) Mia Urem (22683580) Ioli Kotsogianni (9930187) Josephine Lau (20442343) Chao Du (288036) Somayah S. Elsayed (9192571) Nathaniel I. Martin (847378) Iain W. McNae (840777) Patrick Voskamp (2311429) Christoph Mayer (57204) Sébastien Rigali (724082) Navraj Pannu (10163763) Jan Pieter Abrahams (1429531) Lennart Schada von Borzyskowski (22683583) Gilles P. van Wezel (7838948) |
| author_role | author |
| dc.creator.none.fl_str_mv | Chao Li (145513) Mia Urem (22683580) Ioli Kotsogianni (9930187) Josephine Lau (20442343) Chao Du (288036) Somayah S. Elsayed (9192571) Nathaniel I. Martin (847378) Iain W. McNae (840777) Patrick Voskamp (2311429) Christoph Mayer (57204) Sébastien Rigali (724082) Navraj Pannu (10163763) Jan Pieter Abrahams (1429531) Lennart Schada von Borzyskowski (22683583) Gilles P. van Wezel (7838948) |
| dc.date.none.fl_str_mv | 2025-11-25T19:00:33Z |
| dc.identifier.none.fl_str_mv | 10.1371/journal.pbio.3003514.g002 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/figure/Phylogenomic_analysis_of_NagS_/30715202 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Biochemistry Microbiology Ecology Developmental Biology Inorganic Chemistry Biological Sciences not elsewhere classified controls nutrient signaling also revealed 6 highlighted key residues glcnac sensing requires toxicity pathway dependent 6p deacetylase naga novel glcnac 6 key role substrate glcnac novel enzyme work uncovers wall leads unprecedented reaction substrate mycelium structural analogue streptomycetaceae </ streptomyces </ revolves around promiscuous activity nature ’ n </ multicellular lifestyle metabolic checkpoint medicine makers lytic dismantling landmark event hyphal cell highly conserved growth media function analysis clinical antibiotics central metabolism catalytic inhibitor antibiotic production active site >- acetylglucosamine 6p dehydratase |
| dc.title.none.fl_str_mv | Phylogenomic analysis of NagS. |
| dc.type.none.fl_str_mv | Image Figure info:eu-repo/semantics/publishedVersion image |
| description | <p>Phylogenetic tree of NagS proteins in the StringDB database. The branches are annotated with the strain names in which the orthologues occur. <i>Streptomyces</i> and <i>Kitasatospora</i> strains are denoted by blue and green markers, respectively. NagS was exclusively found in members of the <i>Streptomycetaceae.</i> The NagS proteins from <i>S. coelicolor</i> and <i>Streptacidiphilus jiangxiensis</i>, whose GlcNAc-6P dehydratase activity was verified by enzyme assays in vitro, are highlighted with a red marker.</p> |
| eu_rights_str_mv | openAccess |
| id | Manara_5598cd496f02bfe0674f200bb5ea9b75 |
| identifier_str_mv | 10.1371/journal.pbio.3003514.g002 |
| network_acronym_str | Manara |
| network_name_str | ManaraRepo |
| oai_identifier_str | oai:figshare.com:article/30715202 |
| publishDate | 2025 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | Phylogenomic analysis of NagS.Chao Li (145513)Mia Urem (22683580)Ioli Kotsogianni (9930187)Josephine Lau (20442343)Chao Du (288036)Somayah S. Elsayed (9192571)Nathaniel I. Martin (847378)Iain W. McNae (840777)Patrick Voskamp (2311429)Christoph Mayer (57204)Sébastien Rigali (724082)Navraj Pannu (10163763)Jan Pieter Abrahams (1429531)Lennart Schada von Borzyskowski (22683583)Gilles P. van Wezel (7838948)BiochemistryMicrobiologyEcologyDevelopmental BiologyInorganic ChemistryBiological Sciences not elsewhere classifiedcontrols nutrient signalingalso revealed 6highlighted key residuesglcnac sensing requirestoxicity pathway dependent6p deacetylase naganovel glcnac 6key rolesubstrate glcnacnovel enzymework uncoverswall leadsunprecedented reactionsubstrate myceliumstructural analoguestreptomycetaceae </streptomyces </revolves aroundpromiscuous activitynature ’n </multicellular lifestylemetabolic checkpointmedicine makerslytic dismantlinglandmark eventhyphal cellhighly conservedgrowth mediafunction analysisclinical antibioticscentral metabolismcatalytic inhibitorantibiotic productionactive site>- acetylglucosamine6p dehydratase<p>Phylogenetic tree of NagS proteins in the StringDB database. The branches are annotated with the strain names in which the orthologues occur. <i>Streptomyces</i> and <i>Kitasatospora</i> strains are denoted by blue and green markers, respectively. NagS was exclusively found in members of the <i>Streptomycetaceae.</i> The NagS proteins from <i>S. coelicolor</i> and <i>Streptacidiphilus jiangxiensis</i>, whose GlcNAc-6P dehydratase activity was verified by enzyme assays in vitro, are highlighted with a red marker.</p>2025-11-25T19:00:33ZImageFigureinfo:eu-repo/semantics/publishedVersionimage10.1371/journal.pbio.3003514.g002https://figshare.com/articles/figure/Phylogenomic_analysis_of_NagS_/30715202CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/307152022025-11-25T19:00:33Z |
| spellingShingle | Phylogenomic analysis of NagS. Chao Li (145513) Biochemistry Microbiology Ecology Developmental Biology Inorganic Chemistry Biological Sciences not elsewhere classified controls nutrient signaling also revealed 6 highlighted key residues glcnac sensing requires toxicity pathway dependent 6p deacetylase naga novel glcnac 6 key role substrate glcnac novel enzyme work uncovers wall leads unprecedented reaction substrate mycelium structural analogue streptomycetaceae </ streptomyces </ revolves around promiscuous activity nature ’ n </ multicellular lifestyle metabolic checkpoint medicine makers lytic dismantling landmark event hyphal cell highly conserved growth media function analysis clinical antibiotics central metabolism catalytic inhibitor antibiotic production active site >- acetylglucosamine 6p dehydratase |
| status_str | publishedVersion |
| title | Phylogenomic analysis of NagS. |
| title_full | Phylogenomic analysis of NagS. |
| title_fullStr | Phylogenomic analysis of NagS. |
| title_full_unstemmed | Phylogenomic analysis of NagS. |
| title_short | Phylogenomic analysis of NagS. |
| title_sort | Phylogenomic analysis of NagS. |
| topic | Biochemistry Microbiology Ecology Developmental Biology Inorganic Chemistry Biological Sciences not elsewhere classified controls nutrient signaling also revealed 6 highlighted key residues glcnac sensing requires toxicity pathway dependent 6p deacetylase naga novel glcnac 6 key role substrate glcnac novel enzyme work uncovers wall leads unprecedented reaction substrate mycelium structural analogue streptomycetaceae </ streptomyces </ revolves around promiscuous activity nature ’ n </ multicellular lifestyle metabolic checkpoint medicine makers lytic dismantling landmark event hyphal cell highly conserved growth media function analysis clinical antibiotics central metabolism catalytic inhibitor antibiotic production active site >- acetylglucosamine 6p dehydratase |