The non-normalized dynamics of species in the presence of one AKAP/AC nanodomain and in the absence of AKAP/AC nanodomain.
<p>(A) The non-normalized dynamics of species for the simulation in <a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1012564#pcbi.1012564.g002" target="_blank">Fig 2A</a>. (i) The simulation domain and the initial condition of AC and AK...
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2024
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| Summary: | <p>(A) The non-normalized dynamics of species for the simulation in <a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1012564#pcbi.1012564.g002" target="_blank">Fig 2A</a>. (i) The simulation domain and the initial condition of AC and AKAP. This plot is the same as that in <a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1012564#pcbi.1012564.g002" target="_blank">Fig 2A</a>. (ii) The non-normalized dynamics of Ca<sup>2+</sup> and cAMP at the center (solid line; location i) or edge (dashed line; location ii) of the cell membrane. The dynamics of Ca<sup>2+</sup> and cAMP are shown in red and blue, respectively. (iii-vi) The non-normalized dynamics of membrane voltage (iii), PDE (iv), active AC (v), and PKA (vi) (solid line; location i) or edge (dashed line; location ii) of the cell membrane. (B) Same plots as (A) except that the AKAP/AC nanodomain does not exist.</p> <p>(EPS)</p> |
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