Stimulating PV cells at nonsilencing levels does not improve performance of difficult visual discriminations.

Stimulating PV cells at nonsilencing levels does not improve performance of difficult visual discriminations.

<p><b>A)</b> Example of grating stimuli separated by 15° for difficult task (top), schematic of optogenetic manipulations activating only PV cells expressing ChR2 (middle), optogenetic stimulation timings for all four conditions aligned to stimulus onset (STIM ON) or offset (STIM O...

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Bibliographic Details
Main Author: Lilia Kukovska (22683586) (author)
Other Authors: Katharina A. Wilmes (22683589) (author), Natsumi Y. Homma (22683592) (author), Claudia Clopath (324706) (author), Jasper Poort (22683595) (author)
Published: 2025
Subjects:
Biochemistry
Neuroscience
Developmental Biology
Science Policy
Mental Health
Biological Sciences not elsewhere classified
xlink "> inhibition
three major factors
strong competitive interactions
photon imaging showed
balanced cortical activity
primary visual cortex
sustained v1 activity
combined optogenetic activation
v1 cells captured
moderate pv activation
moderate activation
visual discriminations
expressing cells
nonlinear activation
dependent activation
activation strength
task difficulty
stimulus onset
perceptual discrimination
difficult discriminations
delineates conditions
circuit model
behavioral effects
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