Baseline characteristics of participants.
<div><p>Background</p><p>While cardiovascular health (CVH) and social determinants of health (SDoH) are independently associated with mortality, their combined effects on mortality remain unclear. The study aimed to examine the mediating, interacting, and combined effects of...
שמור ב:
| מחבר ראשי: | |
|---|---|
| מחברים אחרים: | |
| יצא לאור: |
2025
|
| נושאים: | |
| תגים: |
הוספת תג
אין תגיות, היה/י הראשונ/ה לתייג את הרשומה!
|
| _version_ | 1849927643184496640 |
|---|---|
| author | Boxuan Pu (19987285) |
| author2 | Zun Wang (1689550) |
| author2_role | author |
| author_facet | Boxuan Pu (19987285) Zun Wang (1689550) |
| author_role | author |
| dc.creator.none.fl_str_mv | Boxuan Pu (19987285) Zun Wang (1689550) |
| dc.date.none.fl_str_mv | 2025-11-24T18:26:39Z |
| dc.identifier.none.fl_str_mv | 10.1371/journal.pone.0337286.t001 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/dataset/Baseline_characteristics_of_participants_/30696884 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Medicine Sociology Developmental Biology Cancer Infectious Diseases Virology life &# 8217 hr ]: 4 87 &# 8211 13 &# 8211 significant additive interaction adding interaction terms significantly elevated risks public health strategies mortality remain unclear cvh significantly mediated ci ]: 2 10 &# 8211 37 ), cvd interaction effects cvd ), 10 ), xlink "> study aimed social determinants national health mediation analysis increased risks higher risks hazard ratio essential 8 cvd mortality confidence interval combined effects clinical practice cardiovascular health cardiovascular disease cancer mortality analyzed data 096 adults |
| dc.title.none.fl_str_mv | Baseline characteristics of participants. |
| dc.type.none.fl_str_mv | Dataset info:eu-repo/semantics/publishedVersion dataset |
| description | <div><p>Background</p><p>While cardiovascular health (CVH) and social determinants of health (SDoH) are independently associated with mortality, their combined effects on mortality remain unclear. The study aimed to examine the mediating, interacting, and combined effects of CVH and SDoH on mortality risks.</p><p>Methods</p><p>We analyzed data from 20,096 adults in the National Health and Nutrition Examination Survey 2007–2018. CVH was assessed using the Life’s Essential 8 (LE8) score and categorized into low, moderate, or high. Cumulative unfavorable SDoH burden was assessed and divided into low and high burdens of unfavorable SDoH. Multivariate Cox regression models were used to analyze the combined associations of SDoH and CVH with mortality. Mediation analysis was used to analyze the mediating role of CVH between SDoH and mortality. Interaction effects were tested by adding interaction terms between CVH and SDoH in the Cox models.</p><p>Results</p><p>A high burden of unfavorable SDoH was associated with higher risks of all-cause, cardiovascular disease (CVD), and cancer mortality. CVH significantly mediated these associations, accounting for 16.70% for all-cause mortality, 22.22% for CVD mortality, and 17.70% for cancer mortality. A significant additive interaction between SDoH and CVH was observed for all-cause mortality. Compared with individuals exhibiting neither risk factor, those with both low CVH and a high burden of unfavorable SDoH had significantly elevated risks of all-cause (hazard ratio [HR]: 4.60; 95% confidence interval [95% CI]: 2.87–7.37), CVD (2.80; 1.10–7.10), and cancer mortality (6.10; 2.13–17.50).</p><p>Conclusions</p><p>The coexistence of low CVH and a high burden of unfavorable SDoH was associated with increased risks of all-cause, CVD, and cancer mortality. These findings have implications for integrating SDoH and CVH in clinical practice and public health strategies to improve survival.</p></div> |
| eu_rights_str_mv | openAccess |
| id | Manara_58cf033ada88fe550102c5a8eecbf0bb |
| identifier_str_mv | 10.1371/journal.pone.0337286.t001 |
| network_acronym_str | Manara |
| network_name_str | ManaraRepo |
| oai_identifier_str | oai:figshare.com:article/30696884 |
| publishDate | 2025 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | Baseline characteristics of participants.Boxuan Pu (19987285)Zun Wang (1689550)MedicineSociologyDevelopmental BiologyCancerInfectious DiseasesVirologylife &# 8217hr ]: 487 &# 821113 &# 8211significant additive interactionadding interaction termssignificantly elevated riskspublic health strategiesmortality remain unclearcvh significantly mediatedci ]: 210 &# 821137 ), cvdinteraction effectscvd ),10 ),xlink ">study aimedsocial determinantsnational healthmediation analysisincreased riskshigher riskshazard ratioessential 8cvd mortalityconfidence intervalcombined effectsclinical practicecardiovascular healthcardiovascular diseasecancer mortalityanalyzed data096 adults<div><p>Background</p><p>While cardiovascular health (CVH) and social determinants of health (SDoH) are independently associated with mortality, their combined effects on mortality remain unclear. The study aimed to examine the mediating, interacting, and combined effects of CVH and SDoH on mortality risks.</p><p>Methods</p><p>We analyzed data from 20,096 adults in the National Health and Nutrition Examination Survey 2007–2018. CVH was assessed using the Life’s Essential 8 (LE8) score and categorized into low, moderate, or high. Cumulative unfavorable SDoH burden was assessed and divided into low and high burdens of unfavorable SDoH. Multivariate Cox regression models were used to analyze the combined associations of SDoH and CVH with mortality. Mediation analysis was used to analyze the mediating role of CVH between SDoH and mortality. Interaction effects were tested by adding interaction terms between CVH and SDoH in the Cox models.</p><p>Results</p><p>A high burden of unfavorable SDoH was associated with higher risks of all-cause, cardiovascular disease (CVD), and cancer mortality. CVH significantly mediated these associations, accounting for 16.70% for all-cause mortality, 22.22% for CVD mortality, and 17.70% for cancer mortality. A significant additive interaction between SDoH and CVH was observed for all-cause mortality. Compared with individuals exhibiting neither risk factor, those with both low CVH and a high burden of unfavorable SDoH had significantly elevated risks of all-cause (hazard ratio [HR]: 4.60; 95% confidence interval [95% CI]: 2.87–7.37), CVD (2.80; 1.10–7.10), and cancer mortality (6.10; 2.13–17.50).</p><p>Conclusions</p><p>The coexistence of low CVH and a high burden of unfavorable SDoH was associated with increased risks of all-cause, CVD, and cancer mortality. These findings have implications for integrating SDoH and CVH in clinical practice and public health strategies to improve survival.</p></div>2025-11-24T18:26:39ZDatasetinfo:eu-repo/semantics/publishedVersiondataset10.1371/journal.pone.0337286.t001https://figshare.com/articles/dataset/Baseline_characteristics_of_participants_/30696884CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/306968842025-11-24T18:26:39Z |
| spellingShingle | Baseline characteristics of participants. Boxuan Pu (19987285) Medicine Sociology Developmental Biology Cancer Infectious Diseases Virology life &# 8217 hr ]: 4 87 &# 8211 13 &# 8211 significant additive interaction adding interaction terms significantly elevated risks public health strategies mortality remain unclear cvh significantly mediated ci ]: 2 10 &# 8211 37 ), cvd interaction effects cvd ), 10 ), xlink "> study aimed social determinants national health mediation analysis increased risks higher risks hazard ratio essential 8 cvd mortality confidence interval combined effects clinical practice cardiovascular health cardiovascular disease cancer mortality analyzed data 096 adults |
| status_str | publishedVersion |
| title | Baseline characteristics of participants. |
| title_full | Baseline characteristics of participants. |
| title_fullStr | Baseline characteristics of participants. |
| title_full_unstemmed | Baseline characteristics of participants. |
| title_short | Baseline characteristics of participants. |
| title_sort | Baseline characteristics of participants. |
| topic | Medicine Sociology Developmental Biology Cancer Infectious Diseases Virology life &# 8217 hr ]: 4 87 &# 8211 13 &# 8211 significant additive interaction adding interaction terms significantly elevated risks public health strategies mortality remain unclear cvh significantly mediated ci ]: 2 10 &# 8211 37 ), cvd interaction effects cvd ), 10 ), xlink "> study aimed social determinants national health mediation analysis increased risks higher risks hazard ratio essential 8 cvd mortality confidence interval combined effects clinical practice cardiovascular health cardiovascular disease cancer mortality analyzed data 096 adults |