Table 2_Comparative efficacy of different dietary interventions for cardiopulmonary fitness at high altitude: a systematic review and network meta-analysis.xlsx
Background<p>A plateau hypoxic environment can increase the physiological burden on athletes. Although nutritional interventions have been recognized as a potential strategy to improve plateau acclimatization, evidence in support of specific dietary patterns is still lacking. This study compar...
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2025
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| _version_ | 1851481411102441472 |
|---|---|
| author | Bin Wang (30851) |
| author2 | Yanle Xiong (21029544) Ning Lin (477803) Jiaojiao Shi (692813) Bo Zou (1332738) Xin Ma (37268) Kaihong Zeng (21029547) Chao Kang (487155) |
| author2_role | author author author author author author author |
| author_facet | Bin Wang (30851) Yanle Xiong (21029544) Ning Lin (477803) Jiaojiao Shi (692813) Bo Zou (1332738) Xin Ma (37268) Kaihong Zeng (21029547) Chao Kang (487155) |
| author_role | author |
| dc.creator.none.fl_str_mv | Bin Wang (30851) Yanle Xiong (21029544) Ning Lin (477803) Jiaojiao Shi (692813) Bo Zou (1332738) Xin Ma (37268) Kaihong Zeng (21029547) Chao Kang (487155) |
| dc.date.none.fl_str_mv | 2025-11-04T13:13:39Z |
| dc.identifier.none.fl_str_mv | 10.3389/fnut.2025.1658950.s002 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/dataset/Table_2_Comparative_efficacy_of_different_dietary_interventions_for_cardiopulmonary_fitness_at_high_altitude_a_systematic_review_and_network_meta-analysis_xlsx/30530636 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Clinical and Sports Nutrition high-altitude nutritional interventions cardiopulmonary fitness network meta-analysis randomized controlled trial |
| dc.title.none.fl_str_mv | Table 2_Comparative efficacy of different dietary interventions for cardiopulmonary fitness at high altitude: a systematic review and network meta-analysis.xlsx |
| dc.type.none.fl_str_mv | Dataset info:eu-repo/semantics/publishedVersion dataset |
| description | Background<p>A plateau hypoxic environment can increase the physiological burden on athletes. Although nutritional interventions have been recognized as a potential strategy to improve plateau acclimatization, evidence in support of specific dietary patterns is still lacking. This study compared the effects of different dietary interventions on cardiopulmonary fitness during plateau exercise through systematic evaluation and network meta-analysis methods.</p>Methods<p>This study systematically reviewed relevant literature up to June 2025 and included 20 randomized controlled trials (RCTs) conducted at altitudes above 1,500 meters involving healthy participants aged 16 years and above who engaged in physical activities. The primary outcomes included cardiopulmonary indicators [maximal oxygen uptake (VO<sub>2max</sub>), heart rate (HR)], blood biomarkers [peripheral oxygen saturation (SpO<sub>2</sub>), hematocrit (HCT)], and subjective perception indicators [rating of perceived exertion (RPE)]. For each outcome, the pooled effects of each intervention compared to others were estimated. Mean difference (MD) or standardized mean difference (SMD) with 95% Credible Intervals (95% CrI) were calculated. The Surface Under the Cumulative Ranking Curve (SUCRA) was used to rank the dietary interventions and quantify their relative effectiveness. In addition, the Grading of Recommendations Assessment, Development and Evaluation (GRADE) approach was applied to assess the quality of evidence.</p>Results<p>A total of 20 randomized controlled trials involving 329 participants were included, evaluating eight dietary interventions. Moderate-quality evidence indicated that carbohydrate supplementation significantly improved the percentage of maximal oxygen uptake (VO<sub>2max</sub>) compared to placebo (SMD = 1.13, 95% CrI: 0.25 to 2.05) and reduced RPE scores (MD = −0.77, 95% CrI: −1.83 to −0.09). Moderate-quality evidence indicated that carbohydrate supplementation combined with glutamine ranked highest in improving SpO<sub>2</sub> (SUCRA 84.54%) and RPE (SUCRA 69.37%), while iron supplementation showed the highest SUCRA rankings for HR (56.54%) and HCT (66.67%). However, these interventions did not demonstrate statistically significant advantages. Notably, the observed increase in VO<sub>2max</sub> exceeded the minimally clinically important difference (MCID) of 1.0 ml/kg/min reported in previous studies, suggesting that the effect of carbohydrate supplementation on VO<sub>2max</sub> may have clinical relevance.</p>Conclusions<p>Differences exist in the effects of different dietary interventions on cardiopulmonary fitness during altitude exercise. The current network meta-analysis indicates that carbohydrate-based strategies show beneficial effects, with carbohydrate plus glutamine supplementation demonstrating greater advantages in SpO<sub>2</sub> and RPE, while carbohydrate alone is more supported in improving VO<sub>2max.</sub> Therefore, carbohydrate-based strategies may serve as effective options to promote altitude acclimatization, whereas iron supplementation may have potential benefits in improving HCT and HR.</p>Systematic review registration<p>https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD420251069629, identifier: CRD420251069629.</p> |
| eu_rights_str_mv | openAccess |
| id | Manara_5b81d8b9014e36f092e29d921dbaa6f2 |
| identifier_str_mv | 10.3389/fnut.2025.1658950.s002 |
| network_acronym_str | Manara |
| network_name_str | ManaraRepo |
| oai_identifier_str | oai:figshare.com:article/30530636 |
| publishDate | 2025 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | Table 2_Comparative efficacy of different dietary interventions for cardiopulmonary fitness at high altitude: a systematic review and network meta-analysis.xlsxBin Wang (30851)Yanle Xiong (21029544)Ning Lin (477803)Jiaojiao Shi (692813)Bo Zou (1332738)Xin Ma (37268)Kaihong Zeng (21029547)Chao Kang (487155)Clinical and Sports Nutritionhigh-altitudenutritional interventionscardiopulmonary fitnessnetwork meta-analysisrandomized controlled trialBackground<p>A plateau hypoxic environment can increase the physiological burden on athletes. Although nutritional interventions have been recognized as a potential strategy to improve plateau acclimatization, evidence in support of specific dietary patterns is still lacking. This study compared the effects of different dietary interventions on cardiopulmonary fitness during plateau exercise through systematic evaluation and network meta-analysis methods.</p>Methods<p>This study systematically reviewed relevant literature up to June 2025 and included 20 randomized controlled trials (RCTs) conducted at altitudes above 1,500 meters involving healthy participants aged 16 years and above who engaged in physical activities. The primary outcomes included cardiopulmonary indicators [maximal oxygen uptake (VO<sub>2max</sub>), heart rate (HR)], blood biomarkers [peripheral oxygen saturation (SpO<sub>2</sub>), hematocrit (HCT)], and subjective perception indicators [rating of perceived exertion (RPE)]. For each outcome, the pooled effects of each intervention compared to others were estimated. Mean difference (MD) or standardized mean difference (SMD) with 95% Credible Intervals (95% CrI) were calculated. The Surface Under the Cumulative Ranking Curve (SUCRA) was used to rank the dietary interventions and quantify their relative effectiveness. In addition, the Grading of Recommendations Assessment, Development and Evaluation (GRADE) approach was applied to assess the quality of evidence.</p>Results<p>A total of 20 randomized controlled trials involving 329 participants were included, evaluating eight dietary interventions. Moderate-quality evidence indicated that carbohydrate supplementation significantly improved the percentage of maximal oxygen uptake (VO<sub>2max</sub>) compared to placebo (SMD = 1.13, 95% CrI: 0.25 to 2.05) and reduced RPE scores (MD = −0.77, 95% CrI: −1.83 to −0.09). Moderate-quality evidence indicated that carbohydrate supplementation combined with glutamine ranked highest in improving SpO<sub>2</sub> (SUCRA 84.54%) and RPE (SUCRA 69.37%), while iron supplementation showed the highest SUCRA rankings for HR (56.54%) and HCT (66.67%). However, these interventions did not demonstrate statistically significant advantages. Notably, the observed increase in VO<sub>2max</sub> exceeded the minimally clinically important difference (MCID) of 1.0 ml/kg/min reported in previous studies, suggesting that the effect of carbohydrate supplementation on VO<sub>2max</sub> may have clinical relevance.</p>Conclusions<p>Differences exist in the effects of different dietary interventions on cardiopulmonary fitness during altitude exercise. The current network meta-analysis indicates that carbohydrate-based strategies show beneficial effects, with carbohydrate plus glutamine supplementation demonstrating greater advantages in SpO<sub>2</sub> and RPE, while carbohydrate alone is more supported in improving VO<sub>2max.</sub> Therefore, carbohydrate-based strategies may serve as effective options to promote altitude acclimatization, whereas iron supplementation may have potential benefits in improving HCT and HR.</p>Systematic review registration<p>https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD420251069629, identifier: CRD420251069629.</p>2025-11-04T13:13:39ZDatasetinfo:eu-repo/semantics/publishedVersiondataset10.3389/fnut.2025.1658950.s002https://figshare.com/articles/dataset/Table_2_Comparative_efficacy_of_different_dietary_interventions_for_cardiopulmonary_fitness_at_high_altitude_a_systematic_review_and_network_meta-analysis_xlsx/30530636CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/305306362025-11-04T13:13:39Z |
| spellingShingle | Table 2_Comparative efficacy of different dietary interventions for cardiopulmonary fitness at high altitude: a systematic review and network meta-analysis.xlsx Bin Wang (30851) Clinical and Sports Nutrition high-altitude nutritional interventions cardiopulmonary fitness network meta-analysis randomized controlled trial |
| status_str | publishedVersion |
| title | Table 2_Comparative efficacy of different dietary interventions for cardiopulmonary fitness at high altitude: a systematic review and network meta-analysis.xlsx |
| title_full | Table 2_Comparative efficacy of different dietary interventions for cardiopulmonary fitness at high altitude: a systematic review and network meta-analysis.xlsx |
| title_fullStr | Table 2_Comparative efficacy of different dietary interventions for cardiopulmonary fitness at high altitude: a systematic review and network meta-analysis.xlsx |
| title_full_unstemmed | Table 2_Comparative efficacy of different dietary interventions for cardiopulmonary fitness at high altitude: a systematic review and network meta-analysis.xlsx |
| title_short | Table 2_Comparative efficacy of different dietary interventions for cardiopulmonary fitness at high altitude: a systematic review and network meta-analysis.xlsx |
| title_sort | Table 2_Comparative efficacy of different dietary interventions for cardiopulmonary fitness at high altitude: a systematic review and network meta-analysis.xlsx |
| topic | Clinical and Sports Nutrition high-altitude nutritional interventions cardiopulmonary fitness network meta-analysis randomized controlled trial |