Distribution and allelic variation of the E. faecalis atlE gene.

A, Phylogenetic reconstruction of AtlE identified in E. faecalis genomes. Open reading frames were trimmed to contain only the GH25 domain, totalling 196 sites of which 167 were parsimony informative. Evolutionary distance was inferred using the Maximum...

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Detalles Bibliográficos
Autor principal:	Robert E. Smith (1942798) (author)
Otros Autores:	Bartosz J. Michno (21587746) (author), Rene L. Christena (21587749) (author), Finn O’Dea (21587752) (author), Jessica L. Davis (15026538) (author), Ian D.E.A. Lidbury (21627647) (author), Marcel G. Alamán-Zárate (21587758) (author), Danai Stefanidi (21587761) (author), Emmanuel Maes (313725) (author), Hannah Fisher (14150685) (author), Tomasz K. Prajsnar (7118912) (author), Stéphane Mesnage (4268956) (author)
Publicado:	2025
Materias:	Biochemistry Microbiology Cell Biology Ecology Immunology Cancer Inorganic Chemistry Biological Sciences not elsewhere classified typically forming pairs research sheds light providing valuable insights opportunistic pathogens displaying novel mechanism underlying innate immune effectors enterococcal polysaccharide antigen enteroccocal polysaccharide antigen characteristic ovoid shape cell wall remodelling cell chain length bacterial cell division host immune system evade host defences div >< p epa )</ p enterococcus faecalis </ >- acetylglucosaminidase atla faecalis </ >- acetylmuramidase n </ faecalis .</ epa plays epa ), stationary phase short chains septum cleavage peptidoglycan hydrolysis mediate evasion locus required limit recognition decoy molecule decoration subunits complex interplay complement molecules >, suggesting
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Sumario:	<p><b>A</b>, Phylogenetic reconstruction of AtlE identified in <i>E. faecalis</i> genomes. Open reading frames were trimmed to contain only the GH25 domain, totalling 196 sites of which 167 were parsimony informative. Evolutionary distance was inferred using the Maximum Likelihood method using the WAG + G4 best fit model. <i>E. faecalis</i> V583 GH25 (N-terminus, inner ring) and DUF5776 (C-terminus, outer ring, green) domains and <i>E. faecalis</i> JH2-2 GW (C-terminus, outer ring, blue) domains were used as references for sequence comparisons. <b>B</b>, Domain organisation of OG1RF and JH2-2 AtlE alleles. Residues numbers are indicated on the top of the sequence; Individual DUF5776 and GW repeats are numbered from N to C-terminus. SP, signal peptide. <b>C</b>, Alphafold structure predictions of GH25, DUF5776 and GW domains from OG1RF and JH2-2. The predicted structures of two DUF5776 and GW domains showing the less similar sequences were aligned (R1 and R6 for OG1RF, R1 and R2 for JH2-2).</p>

Distribution and allelic variation of the <i>E. faecalis atlE</i> gene.

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