Localization of the CTC to the mitochondrion of <i>Toxoplasma gondii</i> is mediated by <i>Tg</i>CIA1.

Localization of the CTC to the mitochondrion of <i>Toxoplasma gondii</i> is mediated by <i>Tg</i>CIA1.

<p><b>(A–D)</b> Immunofluorescence assays of <b>(A)</b> r<i>Tg</i>CIA1-mAID-cMyc/<i>Tg</i>CIA2-HA, <b>(B)</b> r<i>Tg</i>CIA1-mAID-cMyc/<i>Tg</i>MMS19-HA, <b>(C)</b> r<i>Tg</i>CIA2-mAID-H...

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Hlavní autor:	Evie R. Hodgson (21866946) (author)
Další autoři:	Jenni A. Hayward (10063377) (author), Rachel A. Leonard (5195411) (author), F. Victor Makota (16625292) (author), Giel G. van Dooren (10063383) (author)
Vydáno:	2025
Témata:	Biochemistry Medicine Microbiology Cell Biology Immunology Infectious Diseases Environmental Sciences not elsewhere classified Biological Sciences not elsewhere classified Physical Sciences not elsewhere classified iron – sulfur eukaryotic cell biology elucidates pivotal differences div >< p exhibit dual localization nuclear client proteins toxoplasma gondii </ cia targeting complex toxoplasma </ nuclear proteins gondii </ mitochondrial targeting three proteins study provides showed previously scaffold protein remained unclear present evidence otherwise ancient may reflect living relatives important group functionally conserved comprehensive analysis closest free cia1 protein
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Podobné jednotky

The CIA pathway localizes to the mitochondrion of <i>Toxoplasma gondii.</i>
Autor: Evie R. Hodgson (21866946)
Vydáno: (2025)

An elongated CD5 loop is necessary for targeting <i>Tg</i>CIA1 to the mitochondrion of <i>Toxoplasma gondii.</i>
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Characterizing the protein composition of the CIA Targeting Complex (CTC) in <i>Toxoplasma gondii</i> parasites.
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An aromatic amino acid motif in the CD5 loop of <i>Tg</i>CIA1 facilitates mitochondrial targeting.
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Vydáno: (2025)

An aromatic amino acid motif in the CD5 loop of <i>Tg</i>CIA1 facilitates mitochondrial targeting.
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Vydáno: (2025)

Candidate CIA pathway proteins are important for parasite proliferation.
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The CD5 loop of the CIA1 protein is functionally conserved in myzozoans.
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The raw and normalized numerical data for the graphical figures depicted in the manuscript.
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Immunofluorescence assay controls on untagged parasites.
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<i>Toxoplasma gondii</i> tachyzoite cell organization.
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A. Library preparation strategy: poly-A(+) RNAs are captured by complementarity to reverse transcription primer, then second strand is synthesized using random hexamers and handles for sequencing are attached through two rounds of PCR. B. Mapped read distribution by species and by biotype. C and D. Principal component analysis of mouse and <i>T. gondii</i> transcriptomes, respectively. E and F. Volcano plots of Live <i>Toxoplasma</i>-infected mouse and <i>T. gondii</i> time points, respectively. To calculate Log<sub>2</sub>(Fold change), every timepoint is compared to corresponding samples (either macrophage or <i>Toxoplasma</i>) before infection (t = 0 min). Most significant and most upregulated transcripts are labelled. Number of significantly (p ≤ 0.05) downregulated and upregulated genes for each time point is given in blue and red, respectively. In F, 24-hour time point, red dots mark ROP
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Vydáno: (2025)

A. <i>T. gondii</i> gene group changes throughout the time course, expressed as log<sub>2</sub>(fold change) relative to pre-infection tachyzoites (t = 0). Grey area depicts the 95% confidence interval. n value refers to number of genes detected in each group. B. Gene set enrichment plot for most enriched terms from <i>T. gondii</i> transcriptome features at 15 min to 120 min. Five most significant terms are displayed for each database. C and D. Transcriptional profiles of top five upregulated and downregulated <i>T. gondii</i> transcription factors, respectively.
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Vydáno: (2025)

<i>In silico</i> analysis of intrinsically disordered sequences (IDRs) in the SH3 domain-containing proteins in <i>F. graminearum.</i>
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qRT-PCR showing the expression of sexual reproduction-responsive genes in Δ<i>Fghof1</i> and Δ<i>Fgrax2</i> mutants.
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Defects of Δ<i>Fgcyk3</i> mutant in nuclear division.
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Effects of <i>FgHOF1</i> deletion on cytoskeletal and nuclear distribution.
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Δ<i>Fghof1</i> mutant could be compromised in cell division.
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Effect of SH3 domain gene deletions on the pathogenicity of <i>F. graminearum.</i>
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Sensitivity of Δ<i>Fghof1</i> mutant conidia to different DAPI concentrations.
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Subcellular localizations of SH3 domain-containing proteins in <i>F. graminearum</i> hyphae.
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Influence of SH3 domain-containing proteins on sexual development of <i>F. graminearum.</i>
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Impact of SH3 domain-containing proteins on the vegetative growth of <i>F. graminearum.</i>
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Abnormal Δ<i>Fghof1</i> mutant conidia also exhibit nuclear fragmentation.
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PCR gels showing successful deletion of SH3 genes in <i>F. graminearum.</i>
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SH3 domain-containing genes and the subcellular localization of their respective products in <i>F. graminearum.</i>
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Role of SH3 domain-containing proteins on deoxynivalenol (DON) production in <i>F. graminearum.</i>
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