Localization of the CTC to the mitochondrion of <i>Toxoplasma gondii</i> is mediated by <i>Tg</i>CIA1.

Localization of the CTC to the mitochondrion of <i>Toxoplasma gondii</i> is mediated by <i>Tg</i>CIA1.

<p><b>(A–D)</b> Immunofluorescence assays of <b>(A)</b> r<i>Tg</i>CIA1-mAID-cMyc/<i>Tg</i>CIA2-HA, <b>(B)</b> r<i>Tg</i>CIA1-mAID-cMyc/<i>Tg</i>MMS19-HA, <b>(C)</b> r<i>Tg</i>CIA2-mAID-H...

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Αποθηκεύτηκε σε:

Λεπτομέρειες βιβλιογραφικής εγγραφής
Κύριος συγγραφέας:	Evie R. Hodgson (21866946) (author)
Άλλοι συγγραφείς:	Jenni A. Hayward (10063377) (author), Rachel A. Leonard (5195411) (author), F. Victor Makota (16625292) (author), Giel G. van Dooren (10063383) (author)
Έκδοση:	2025
Θέματα:	Biochemistry Medicine Microbiology Cell Biology Immunology Infectious Diseases Environmental Sciences not elsewhere classified Biological Sciences not elsewhere classified Physical Sciences not elsewhere classified iron – sulfur eukaryotic cell biology elucidates pivotal differences div >< p exhibit dual localization nuclear client proteins toxoplasma gondii </ cia targeting complex toxoplasma </ nuclear proteins gondii </ mitochondrial targeting three proteins study provides showed previously scaffold protein remained unclear present evidence otherwise ancient may reflect living relatives important group functionally conserved comprehensive analysis closest free cia1 protein
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Παρόμοια τεκμήρια

The CIA pathway localizes to the mitochondrion of <i>Toxoplasma gondii.</i>
ανά: Evie R. Hodgson (21866946)
Έκδοση: (2025)

An elongated CD5 loop is necessary for targeting <i>Tg</i>CIA1 to the mitochondrion of <i>Toxoplasma gondii.</i>
ανά: Evie R. Hodgson (21866946)
Έκδοση: (2025)

Characterizing the protein composition of the CIA Targeting Complex (CTC) in <i>Toxoplasma gondii</i> parasites.
ανά: Evie R. Hodgson (21866946)
Έκδοση: (2025)

Characterizing the protein composition of the CIA Targeting Complex (CTC) in <i>Toxoplasma gondii</i> parasites.
ανά: Evie R. Hodgson (21866946)
Έκδοση: (2025)

The CD5 loop of <i>Tg</i>CIA1 is sufficient to target GFP to the mitochondrion.
ανά: Evie R. Hodgson (21866946)
Έκδοση: (2025)

Epitope tagging candidate CIA pathway proteins in <i>Toxoplasma gondii.</i>
ανά: Evie R. Hodgson (21866946)
Έκδοση: (2025)

Epitope tagging of candidate CIA pathway proteins in <i>Toxoplasma gondii.</i>
ανά: Evie R. Hodgson (21866946)
Έκδοση: (2025)

Characterizing the effects of depleting candidate CIA pathway proteins in <i>Toxoplasma gondii</i> parasites.
ανά: Evie R. Hodgson (21866946)
Έκδοση: (2025)

Generating IAA-regulatable strains of candidate CIA pathway proteins in <i>Toxoplasma gondii.</i>
ανά: Evie R. Hodgson (21866946)
Έκδοση: (2025)

A model for the spatial organization and evolution of the CIA pathway in <i>Toxoplasma gondii</i> and related eukaryotes.
ανά: Evie R. Hodgson (21866946)
Έκδοση: (2025)

Depletion of most candidate CIA pathway proteins leads to a decrease in protein translation in <i>Toxoplasma gondii</i> parasites.
ανά: Evie R. Hodgson (21866946)
Έκδοση: (2025)

The CD5 loop of <i>Tg</i>CIA1 is sufficient for mitochondrial targeting, with the positioning of the loop important for <i>Tg</i>CIA1 function.
ανά: Evie R. Hodgson (21866946)
Έκδοση: (2025)

The mitochondrial localization of <i>Tg</i>CIA1 is not dependent on other candidate CIA pathway proteins.
ανά: Evie R. Hodgson (21866946)
Έκδοση: (2025)

Epitope tagging <i>Tg</i>ABCE1 in the r<i>Tg</i>CIA1-mAID-HA and r<i>Tg</i>Dre2-mAID-HA lines.
ανά: Evie R. Hodgson (21866946)
Έκδοση: (2025)

The effects of mutating the CD loops of <i>Tg</i>CIA1 on mitochondrial morphology and parasite proliferation.
ανά: Evie R. Hodgson (21866946)
Έκδοση: (2025)

Multiple sequence alignment of the <i>Tg</i>CIA2 protein with homologs from other eukaryotes.
ανά: Evie R. Hodgson (21866946)
Έκδοση: (2025)

An aromatic amino acid motif in the CD5 loop of <i>Tg</i>CIA1 facilitates mitochondrial targeting.
ανά: Evie R. Hodgson (21866946)
Έκδοση: (2025)

An aromatic amino acid motif in the CD5 loop of <i>Tg</i>CIA1 facilitates mitochondrial targeting.
ανά: Evie R. Hodgson (21866946)
Έκδοση: (2025)

Candidate CIA pathway proteins are important for parasite proliferation.
ανά: Evie R. Hodgson (21866946)
Έκδοση: (2025)

The CD5 loop of the CIA1 protein is functionally conserved in myzozoans.
ανά: Evie R. Hodgson (21866946)
Έκδοση: (2025)

The raw and normalized numerical data for the graphical figures depicted in the manuscript.
ανά: Evie R. Hodgson (21866946)
Έκδοση: (2025)

Immunofluorescence assay controls on untagged parasites.
ανά: Evie R. Hodgson (21866946)
Έκδοση: (2025)

<i>Toxoplasma gondii</i> tachyzoite cell organization.
ανά: Romuald Haase (22339777)
Έκδοση: (2025)

A. Library preparation strategy: poly-A(+) RNAs are captured by complementarity to reverse transcription primer, then second strand is synthesized using random hexamers and handles for sequencing are attached through two rounds of PCR. B. Mapped read distribution by species and by biotype. C and D. Principal component analysis of mouse and <i>T. gondii</i> transcriptomes, respectively. E and F. Volcano plots of Live <i>Toxoplasma</i>-infected mouse and <i>T. gondii</i> time points, respectively. To calculate Log<sub>2</sub>(Fold change), every timepoint is compared to corresponding samples (either macrophage or <i>Toxoplasma</i>) before infection (t = 0 min). Most significant and most upregulated transcripts are labelled. Number of significantly (p ≤ 0.05) downregulated and upregulated genes for each time point is given in blue and red, respectively. In F, 24-hour time point, red dots mark ROP
ανά: Dominykas Murza (22676289)
Έκδοση: (2025)

A. <i>T. gondii</i> gene group changes throughout the time course, expressed as log<sub>2</sub>(fold change) relative to pre-infection tachyzoites (t = 0). Grey area depicts the 95% confidence interval. n value refers to number of genes detected in each group. B. Gene set enrichment plot for most enriched terms from <i>T. gondii</i> transcriptome features at 15 min to 120 min. Five most significant terms are displayed for each database. C and D. Transcriptional profiles of top five upregulated and downregulated <i>T. gondii</i> transcription factors, respectively.
ανά: Dominykas Murza (22676289)
Έκδοση: (2025)

<i>In silico</i> analysis of intrinsically disordered sequences (IDRs) in the SH3 domain-containing proteins in <i>F. graminearum.</i>
ανά: Yakubu Saddeeq Abubakar (5558399)
Έκδοση: (2025)

qRT-PCR showing the expression of sexual reproduction-responsive genes in Δ<i>Fghof1</i> and Δ<i>Fgrax2</i> mutants.
ανά: Yakubu Saddeeq Abubakar (5558399)
Έκδοση: (2025)

Defects of Δ<i>Fgcyk3</i> mutant in nuclear division.
ανά: Yakubu Saddeeq Abubakar (5558399)
Έκδοση: (2025)

Effects of <i>FgHOF1</i> deletion on cytoskeletal and nuclear distribution.
ανά: Yakubu Saddeeq Abubakar (5558399)
Έκδοση: (2025)

Δ<i>Fghof1</i> mutant could be compromised in cell division.
ανά: Yakubu Saddeeq Abubakar (5558399)
Έκδοση: (2025)

Effect of SH3 domain gene deletions on the pathogenicity of <i>F. graminearum.</i>
ανά: Yakubu Saddeeq Abubakar (5558399)
Έκδοση: (2025)

Sensitivity of Δ<i>Fghof1</i> mutant conidia to different DAPI concentrations.
ανά: Yakubu Saddeeq Abubakar (5558399)
Έκδοση: (2025)

Subcellular localizations of SH3 domain-containing proteins in <i>F. graminearum</i> hyphae.
ανά: Yakubu Saddeeq Abubakar (5558399)
Έκδοση: (2025)

Influence of SH3 domain-containing proteins on sexual development of <i>F. graminearum.</i>
ανά: Yakubu Saddeeq Abubakar (5558399)
Έκδοση: (2025)

Impact of SH3 domain-containing proteins on the vegetative growth of <i>F. graminearum.</i>
ανά: Yakubu Saddeeq Abubakar (5558399)
Έκδοση: (2025)

Abnormal Δ<i>Fghof1</i> mutant conidia also exhibit nuclear fragmentation.
ανά: Yakubu Saddeeq Abubakar (5558399)
Έκδοση: (2025)

PCR gels showing successful deletion of SH3 genes in <i>F. graminearum.</i>
ανά: Yakubu Saddeeq Abubakar (5558399)
Έκδοση: (2025)

SH3 domain-containing genes and the subcellular localization of their respective products in <i>F. graminearum.</i>
ανά: Yakubu Saddeeq Abubakar (5558399)
Έκδοση: (2025)

SH3 domain-containing proteins exhibit features of phase separation in <i>F. graminearum.</i>
ανά: Yakubu Saddeeq Abubakar (5558399)
Έκδοση: (2025)

Role of SH3 domain-containing proteins on deoxynivalenol (DON) production in <i>F. graminearum.</i>
ανά: Yakubu Saddeeq Abubakar (5558399)
Έκδοση: (2025)

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