Localization of the CTC to the mitochondrion of <i>Toxoplasma gondii</i> is mediated by <i>Tg</i>CIA1.

Localization of the CTC to the mitochondrion of <i>Toxoplasma gondii</i> is mediated by <i>Tg</i>CIA1.

<p><b>(A–D)</b> Immunofluorescence assays of <b>(A)</b> r<i>Tg</i>CIA1-mAID-cMyc/<i>Tg</i>CIA2-HA, <b>(B)</b> r<i>Tg</i>CIA1-mAID-cMyc/<i>Tg</i>MMS19-HA, <b>(C)</b> r<i>Tg</i>CIA2-mAID-H...

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מידע ביבליוגרפי
מחבר ראשי:	Evie R. Hodgson (21866946) (author)
מחברים אחרים:	Jenni A. Hayward (10063377) (author), Rachel A. Leonard (5195411) (author), F. Victor Makota (16625292) (author), Giel G. van Dooren (10063383) (author)
יצא לאור:	2025
נושאים:	Biochemistry Medicine Microbiology Cell Biology Immunology Infectious Diseases Environmental Sciences not elsewhere classified Biological Sciences not elsewhere classified Physical Sciences not elsewhere classified iron – sulfur eukaryotic cell biology elucidates pivotal differences div >< p exhibit dual localization nuclear client proteins toxoplasma gondii </ cia targeting complex toxoplasma </ nuclear proteins gondii </ mitochondrial targeting three proteins study provides showed previously scaffold protein remained unclear present evidence otherwise ancient may reflect living relatives important group functionally conserved comprehensive analysis closest free cia1 protein
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פריטים דומים

The CIA pathway localizes to the mitochondrion of <i>Toxoplasma gondii.</i>
מאת: Evie R. Hodgson (21866946)
יצא לאור: (2025)

An elongated CD5 loop is necessary for targeting <i>Tg</i>CIA1 to the mitochondrion of <i>Toxoplasma gondii.</i>
מאת: Evie R. Hodgson (21866946)
יצא לאור: (2025)

Characterizing the protein composition of the CIA Targeting Complex (CTC) in <i>Toxoplasma gondii</i> parasites.
מאת: Evie R. Hodgson (21866946)
יצא לאור: (2025)

Characterizing the protein composition of the CIA Targeting Complex (CTC) in <i>Toxoplasma gondii</i> parasites.
מאת: Evie R. Hodgson (21866946)
יצא לאור: (2025)

The CD5 loop of <i>Tg</i>CIA1 is sufficient to target GFP to the mitochondrion.
מאת: Evie R. Hodgson (21866946)
יצא לאור: (2025)

Epitope tagging candidate CIA pathway proteins in <i>Toxoplasma gondii.</i>
מאת: Evie R. Hodgson (21866946)
יצא לאור: (2025)

Epitope tagging of candidate CIA pathway proteins in <i>Toxoplasma gondii.</i>
מאת: Evie R. Hodgson (21866946)
יצא לאור: (2025)

Characterizing the effects of depleting candidate CIA pathway proteins in <i>Toxoplasma gondii</i> parasites.
מאת: Evie R. Hodgson (21866946)
יצא לאור: (2025)

Generating IAA-regulatable strains of candidate CIA pathway proteins in <i>Toxoplasma gondii.</i>
מאת: Evie R. Hodgson (21866946)
יצא לאור: (2025)

A model for the spatial organization and evolution of the CIA pathway in <i>Toxoplasma gondii</i> and related eukaryotes.
מאת: Evie R. Hodgson (21866946)
יצא לאור: (2025)

Depletion of most candidate CIA pathway proteins leads to a decrease in protein translation in <i>Toxoplasma gondii</i> parasites.
מאת: Evie R. Hodgson (21866946)
יצא לאור: (2025)

The CD5 loop of <i>Tg</i>CIA1 is sufficient for mitochondrial targeting, with the positioning of the loop important for <i>Tg</i>CIA1 function.
מאת: Evie R. Hodgson (21866946)
יצא לאור: (2025)

The mitochondrial localization of <i>Tg</i>CIA1 is not dependent on other candidate CIA pathway proteins.
מאת: Evie R. Hodgson (21866946)
יצא לאור: (2025)

Epitope tagging <i>Tg</i>ABCE1 in the r<i>Tg</i>CIA1-mAID-HA and r<i>Tg</i>Dre2-mAID-HA lines.
מאת: Evie R. Hodgson (21866946)
יצא לאור: (2025)

The effects of mutating the CD loops of <i>Tg</i>CIA1 on mitochondrial morphology and parasite proliferation.
מאת: Evie R. Hodgson (21866946)
יצא לאור: (2025)

Multiple sequence alignment of the <i>Tg</i>CIA2 protein with homologs from other eukaryotes.
מאת: Evie R. Hodgson (21866946)
יצא לאור: (2025)

An aromatic amino acid motif in the CD5 loop of <i>Tg</i>CIA1 facilitates mitochondrial targeting.
מאת: Evie R. Hodgson (21866946)
יצא לאור: (2025)

An aromatic amino acid motif in the CD5 loop of <i>Tg</i>CIA1 facilitates mitochondrial targeting.
מאת: Evie R. Hodgson (21866946)
יצא לאור: (2025)

Candidate CIA pathway proteins are important for parasite proliferation.
מאת: Evie R. Hodgson (21866946)
יצא לאור: (2025)

The CD5 loop of the CIA1 protein is functionally conserved in myzozoans.
מאת: Evie R. Hodgson (21866946)
יצא לאור: (2025)

The raw and normalized numerical data for the graphical figures depicted in the manuscript.
מאת: Evie R. Hodgson (21866946)
יצא לאור: (2025)

Immunofluorescence assay controls on untagged parasites.
מאת: Evie R. Hodgson (21866946)
יצא לאור: (2025)

<i>Toxoplasma gondii</i> tachyzoite cell organization.
מאת: Romuald Haase (22339777)
יצא לאור: (2025)

A. Library preparation strategy: poly-A(+) RNAs are captured by complementarity to reverse transcription primer, then second strand is synthesized using random hexamers and handles for sequencing are attached through two rounds of PCR. B. Mapped read distribution by species and by biotype. C and D. Principal component analysis of mouse and <i>T. gondii</i> transcriptomes, respectively. E and F. Volcano plots of Live <i>Toxoplasma</i>-infected mouse and <i>T. gondii</i> time points, respectively. To calculate Log<sub>2</sub>(Fold change), every timepoint is compared to corresponding samples (either macrophage or <i>Toxoplasma</i>) before infection (t = 0 min). Most significant and most upregulated transcripts are labelled. Number of significantly (p ≤ 0.05) downregulated and upregulated genes for each time point is given in blue and red, respectively. In F, 24-hour time point, red dots mark ROP
מאת: Dominykas Murza (22676289)
יצא לאור: (2025)

A. <i>T. gondii</i> gene group changes throughout the time course, expressed as log<sub>2</sub>(fold change) relative to pre-infection tachyzoites (t = 0). Grey area depicts the 95% confidence interval. n value refers to number of genes detected in each group. B. Gene set enrichment plot for most enriched terms from <i>T. gondii</i> transcriptome features at 15 min to 120 min. Five most significant terms are displayed for each database. C and D. Transcriptional profiles of top five upregulated and downregulated <i>T. gondii</i> transcription factors, respectively.
מאת: Dominykas Murza (22676289)
יצא לאור: (2025)

<i>In silico</i> analysis of intrinsically disordered sequences (IDRs) in the SH3 domain-containing proteins in <i>F. graminearum.</i>
מאת: Yakubu Saddeeq Abubakar (5558399)
יצא לאור: (2025)

qRT-PCR showing the expression of sexual reproduction-responsive genes in Δ<i>Fghof1</i> and Δ<i>Fgrax2</i> mutants.
מאת: Yakubu Saddeeq Abubakar (5558399)
יצא לאור: (2025)

Defects of Δ<i>Fgcyk3</i> mutant in nuclear division.
מאת: Yakubu Saddeeq Abubakar (5558399)
יצא לאור: (2025)

Effects of <i>FgHOF1</i> deletion on cytoskeletal and nuclear distribution.
מאת: Yakubu Saddeeq Abubakar (5558399)
יצא לאור: (2025)

Δ<i>Fghof1</i> mutant could be compromised in cell division.
מאת: Yakubu Saddeeq Abubakar (5558399)
יצא לאור: (2025)

Effect of SH3 domain gene deletions on the pathogenicity of <i>F. graminearum.</i>
מאת: Yakubu Saddeeq Abubakar (5558399)
יצא לאור: (2025)

Sensitivity of Δ<i>Fghof1</i> mutant conidia to different DAPI concentrations.
מאת: Yakubu Saddeeq Abubakar (5558399)
יצא לאור: (2025)

Subcellular localizations of SH3 domain-containing proteins in <i>F. graminearum</i> hyphae.
מאת: Yakubu Saddeeq Abubakar (5558399)
יצא לאור: (2025)

Influence of SH3 domain-containing proteins on sexual development of <i>F. graminearum.</i>
מאת: Yakubu Saddeeq Abubakar (5558399)
יצא לאור: (2025)

Impact of SH3 domain-containing proteins on the vegetative growth of <i>F. graminearum.</i>
מאת: Yakubu Saddeeq Abubakar (5558399)
יצא לאור: (2025)

Abnormal Δ<i>Fghof1</i> mutant conidia also exhibit nuclear fragmentation.
מאת: Yakubu Saddeeq Abubakar (5558399)
יצא לאור: (2025)

PCR gels showing successful deletion of SH3 genes in <i>F. graminearum.</i>
מאת: Yakubu Saddeeq Abubakar (5558399)
יצא לאור: (2025)

SH3 domain-containing genes and the subcellular localization of their respective products in <i>F. graminearum.</i>
מאת: Yakubu Saddeeq Abubakar (5558399)
יצא לאור: (2025)

SH3 domain-containing proteins exhibit features of phase separation in <i>F. graminearum.</i>
מאת: Yakubu Saddeeq Abubakar (5558399)
יצא לאור: (2025)

Role of SH3 domain-containing proteins on deoxynivalenol (DON) production in <i>F. graminearum.</i>
מאת: Yakubu Saddeeq Abubakar (5558399)
יצא לאור: (2025)

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