Localization of the CTC to the mitochondrion of <i>Toxoplasma gondii</i> is mediated by <i>Tg</i>CIA1.

Localization of the CTC to the mitochondrion of <i>Toxoplasma gondii</i> is mediated by <i>Tg</i>CIA1.

<p><b>(A–D)</b> Immunofluorescence assays of <b>(A)</b> r<i>Tg</i>CIA1-mAID-cMyc/<i>Tg</i>CIA2-HA, <b>(B)</b> r<i>Tg</i>CIA1-mAID-cMyc/<i>Tg</i>MMS19-HA, <b>(C)</b> r<i>Tg</i>CIA2-mAID-H...

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Մատենագիտական մանրամասներ
Հիմնական հեղինակ:	Evie R. Hodgson (21866946) (author)
Այլ հեղինակներ:	Jenni A. Hayward (10063377) (author), Rachel A. Leonard (5195411) (author), F. Victor Makota (16625292) (author), Giel G. van Dooren (10063383) (author)
Հրապարակվել է:	2025
Խորագրեր:	Biochemistry Medicine Microbiology Cell Biology Immunology Infectious Diseases Environmental Sciences not elsewhere classified Biological Sciences not elsewhere classified Physical Sciences not elsewhere classified iron – sulfur eukaryotic cell biology elucidates pivotal differences div >< p exhibit dual localization nuclear client proteins toxoplasma gondii </ cia targeting complex toxoplasma </ nuclear proteins gondii </ mitochondrial targeting three proteins study provides showed previously scaffold protein remained unclear present evidence otherwise ancient may reflect living relatives important group functionally conserved comprehensive analysis closest free cia1 protein
Ցուցիչներ:	Ավելացրեք ցուցիչ Չկան պիտակներ, Եղեք առաջինը, ով նշում է այս գրառումը!

Նմանատիպ նյութեր

The CIA pathway localizes to the mitochondrion of <i>Toxoplasma gondii.</i>
‌: Evie R. Hodgson (21866946)
Հրապարակվել է: (2025)

An elongated CD5 loop is necessary for targeting <i>Tg</i>CIA1 to the mitochondrion of <i>Toxoplasma gondii.</i>
‌: Evie R. Hodgson (21866946)
Հրապարակվել է: (2025)

Characterizing the protein composition of the CIA Targeting Complex (CTC) in <i>Toxoplasma gondii</i> parasites.
‌: Evie R. Hodgson (21866946)
Հրապարակվել է: (2025)

Characterizing the protein composition of the CIA Targeting Complex (CTC) in <i>Toxoplasma gondii</i> parasites.
‌: Evie R. Hodgson (21866946)
Հրապարակվել է: (2025)

The CD5 loop of <i>Tg</i>CIA1 is sufficient to target GFP to the mitochondrion.
‌: Evie R. Hodgson (21866946)
Հրապարակվել է: (2025)

Epitope tagging candidate CIA pathway proteins in <i>Toxoplasma gondii.</i>
‌: Evie R. Hodgson (21866946)
Հրապարակվել է: (2025)

Epitope tagging of candidate CIA pathway proteins in <i>Toxoplasma gondii.</i>
‌: Evie R. Hodgson (21866946)
Հրապարակվել է: (2025)

Characterizing the effects of depleting candidate CIA pathway proteins in <i>Toxoplasma gondii</i> parasites.
‌: Evie R. Hodgson (21866946)
Հրապարակվել է: (2025)

Generating IAA-regulatable strains of candidate CIA pathway proteins in <i>Toxoplasma gondii.</i>
‌: Evie R. Hodgson (21866946)
Հրապարակվել է: (2025)

A model for the spatial organization and evolution of the CIA pathway in <i>Toxoplasma gondii</i> and related eukaryotes.
‌: Evie R. Hodgson (21866946)
Հրապարակվել է: (2025)

Depletion of most candidate CIA pathway proteins leads to a decrease in protein translation in <i>Toxoplasma gondii</i> parasites.
‌: Evie R. Hodgson (21866946)
Հրապարակվել է: (2025)

The CD5 loop of <i>Tg</i>CIA1 is sufficient for mitochondrial targeting, with the positioning of the loop important for <i>Tg</i>CIA1 function.
‌: Evie R. Hodgson (21866946)
Հրապարակվել է: (2025)

The mitochondrial localization of <i>Tg</i>CIA1 is not dependent on other candidate CIA pathway proteins.
‌: Evie R. Hodgson (21866946)
Հրապարակվել է: (2025)

Epitope tagging <i>Tg</i>ABCE1 in the r<i>Tg</i>CIA1-mAID-HA and r<i>Tg</i>Dre2-mAID-HA lines.
‌: Evie R. Hodgson (21866946)
Հրապարակվել է: (2025)

The effects of mutating the CD loops of <i>Tg</i>CIA1 on mitochondrial morphology and parasite proliferation.
‌: Evie R. Hodgson (21866946)
Հրապարակվել է: (2025)

Multiple sequence alignment of the <i>Tg</i>CIA2 protein with homologs from other eukaryotes.
‌: Evie R. Hodgson (21866946)
Հրապարակվել է: (2025)

An aromatic amino acid motif in the CD5 loop of <i>Tg</i>CIA1 facilitates mitochondrial targeting.
‌: Evie R. Hodgson (21866946)
Հրապարակվել է: (2025)

An aromatic amino acid motif in the CD5 loop of <i>Tg</i>CIA1 facilitates mitochondrial targeting.
‌: Evie R. Hodgson (21866946)
Հրապարակվել է: (2025)

Candidate CIA pathway proteins are important for parasite proliferation.
‌: Evie R. Hodgson (21866946)
Հրապարակվել է: (2025)

The CD5 loop of the CIA1 protein is functionally conserved in myzozoans.
‌: Evie R. Hodgson (21866946)
Հրապարակվել է: (2025)

The raw and normalized numerical data for the graphical figures depicted in the manuscript.
‌: Evie R. Hodgson (21866946)
Հրապարակվել է: (2025)

Immunofluorescence assay controls on untagged parasites.
‌: Evie R. Hodgson (21866946)
Հրապարակվել է: (2025)

<i>Toxoplasma gondii</i> tachyzoite cell organization.
‌: Romuald Haase (22339777)
Հրապարակվել է: (2025)

A. Library preparation strategy: poly-A(+) RNAs are captured by complementarity to reverse transcription primer, then second strand is synthesized using random hexamers and handles for sequencing are attached through two rounds of PCR. B. Mapped read distribution by species and by biotype. C and D. Principal component analysis of mouse and <i>T. gondii</i> transcriptomes, respectively. E and F. Volcano plots of Live <i>Toxoplasma</i>-infected mouse and <i>T. gondii</i> time points, respectively. To calculate Log<sub>2</sub>(Fold change), every timepoint is compared to corresponding samples (either macrophage or <i>Toxoplasma</i>) before infection (t = 0 min). Most significant and most upregulated transcripts are labelled. Number of significantly (p ≤ 0.05) downregulated and upregulated genes for each time point is given in blue and red, respectively. In F, 24-hour time point, red dots mark ROP
‌: Dominykas Murza (22676289)
Հրապարակվել է: (2025)

A. <i>T. gondii</i> gene group changes throughout the time course, expressed as log<sub>2</sub>(fold change) relative to pre-infection tachyzoites (t = 0). Grey area depicts the 95% confidence interval. n value refers to number of genes detected in each group. B. Gene set enrichment plot for most enriched terms from <i>T. gondii</i> transcriptome features at 15 min to 120 min. Five most significant terms are displayed for each database. C and D. Transcriptional profiles of top five upregulated and downregulated <i>T. gondii</i> transcription factors, respectively.
‌: Dominykas Murza (22676289)
Հրապարակվել է: (2025)

<i>In silico</i> analysis of intrinsically disordered sequences (IDRs) in the SH3 domain-containing proteins in <i>F. graminearum.</i>
‌: Yakubu Saddeeq Abubakar (5558399)
Հրապարակվել է: (2025)

qRT-PCR showing the expression of sexual reproduction-responsive genes in Δ<i>Fghof1</i> and Δ<i>Fgrax2</i> mutants.
‌: Yakubu Saddeeq Abubakar (5558399)
Հրապարակվել է: (2025)

Defects of Δ<i>Fgcyk3</i> mutant in nuclear division.
‌: Yakubu Saddeeq Abubakar (5558399)
Հրապարակվել է: (2025)

Effects of <i>FgHOF1</i> deletion on cytoskeletal and nuclear distribution.
‌: Yakubu Saddeeq Abubakar (5558399)
Հրապարակվել է: (2025)

Δ<i>Fghof1</i> mutant could be compromised in cell division.
‌: Yakubu Saddeeq Abubakar (5558399)
Հրապարակվել է: (2025)

Effect of SH3 domain gene deletions on the pathogenicity of <i>F. graminearum.</i>
‌: Yakubu Saddeeq Abubakar (5558399)
Հրապարակվել է: (2025)

Sensitivity of Δ<i>Fghof1</i> mutant conidia to different DAPI concentrations.
‌: Yakubu Saddeeq Abubakar (5558399)
Հրապարակվել է: (2025)

Subcellular localizations of SH3 domain-containing proteins in <i>F. graminearum</i> hyphae.
‌: Yakubu Saddeeq Abubakar (5558399)
Հրապարակվել է: (2025)

Influence of SH3 domain-containing proteins on sexual development of <i>F. graminearum.</i>
‌: Yakubu Saddeeq Abubakar (5558399)
Հրապարակվել է: (2025)

Impact of SH3 domain-containing proteins on the vegetative growth of <i>F. graminearum.</i>
‌: Yakubu Saddeeq Abubakar (5558399)
Հրապարակվել է: (2025)

Abnormal Δ<i>Fghof1</i> mutant conidia also exhibit nuclear fragmentation.
‌: Yakubu Saddeeq Abubakar (5558399)
Հրապարակվել է: (2025)

PCR gels showing successful deletion of SH3 genes in <i>F. graminearum.</i>
‌: Yakubu Saddeeq Abubakar (5558399)
Հրապարակվել է: (2025)

SH3 domain-containing genes and the subcellular localization of their respective products in <i>F. graminearum.</i>
‌: Yakubu Saddeeq Abubakar (5558399)
Հրապարակվել է: (2025)

SH3 domain-containing proteins exhibit features of phase separation in <i>F. graminearum.</i>
‌: Yakubu Saddeeq Abubakar (5558399)
Հրապարակվել է: (2025)

Role of SH3 domain-containing proteins on deoxynivalenol (DON) production in <i>F. graminearum.</i>
‌: Yakubu Saddeeq Abubakar (5558399)
Հրապարակվել է: (2025)

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