Localization of the CTC to the mitochondrion of <i>Toxoplasma gondii</i> is mediated by <i>Tg</i>CIA1.

Localization of the CTC to the mitochondrion of <i>Toxoplasma gondii</i> is mediated by <i>Tg</i>CIA1.

<p><b>(A–D)</b> Immunofluorescence assays of <b>(A)</b> r<i>Tg</i>CIA1-mAID-cMyc/<i>Tg</i>CIA2-HA, <b>(B)</b> r<i>Tg</i>CIA1-mAID-cMyc/<i>Tg</i>MMS19-HA, <b>(C)</b> r<i>Tg</i>CIA2-mAID-H...

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Bibliografische gegevens
Hoofdauteur:	Evie R. Hodgson (21866946) (author)
Andere auteurs:	Jenni A. Hayward (10063377) (author), Rachel A. Leonard (5195411) (author), F. Victor Makota (16625292) (author), Giel G. van Dooren (10063383) (author)
Gepubliceerd in:	2025
Onderwerpen:	Biochemistry Medicine Microbiology Cell Biology Immunology Infectious Diseases Environmental Sciences not elsewhere classified Biological Sciences not elsewhere classified Physical Sciences not elsewhere classified iron – sulfur eukaryotic cell biology elucidates pivotal differences div >< p exhibit dual localization nuclear client proteins toxoplasma gondii </ cia targeting complex toxoplasma </ nuclear proteins gondii </ mitochondrial targeting three proteins study provides showed previously scaffold protein remained unclear present evidence otherwise ancient may reflect living relatives important group functionally conserved comprehensive analysis closest free cia1 protein
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The CIA pathway localizes to the mitochondrion of <i>Toxoplasma gondii.</i>
door: Evie R. Hodgson (21866946)
Gepubliceerd in: (2025)

An elongated CD5 loop is necessary for targeting <i>Tg</i>CIA1 to the mitochondrion of <i>Toxoplasma gondii.</i>
door: Evie R. Hodgson (21866946)
Gepubliceerd in: (2025)

Characterizing the protein composition of the CIA Targeting Complex (CTC) in <i>Toxoplasma gondii</i> parasites.
door: Evie R. Hodgson (21866946)
Gepubliceerd in: (2025)

Characterizing the protein composition of the CIA Targeting Complex (CTC) in <i>Toxoplasma gondii</i> parasites.
door: Evie R. Hodgson (21866946)
Gepubliceerd in: (2025)

The CD5 loop of <i>Tg</i>CIA1 is sufficient to target GFP to the mitochondrion.
door: Evie R. Hodgson (21866946)
Gepubliceerd in: (2025)

Epitope tagging candidate CIA pathway proteins in <i>Toxoplasma gondii.</i>
door: Evie R. Hodgson (21866946)
Gepubliceerd in: (2025)

Epitope tagging of candidate CIA pathway proteins in <i>Toxoplasma gondii.</i>
door: Evie R. Hodgson (21866946)
Gepubliceerd in: (2025)

Characterizing the effects of depleting candidate CIA pathway proteins in <i>Toxoplasma gondii</i> parasites.
door: Evie R. Hodgson (21866946)
Gepubliceerd in: (2025)

Generating IAA-regulatable strains of candidate CIA pathway proteins in <i>Toxoplasma gondii.</i>
door: Evie R. Hodgson (21866946)
Gepubliceerd in: (2025)

A model for the spatial organization and evolution of the CIA pathway in <i>Toxoplasma gondii</i> and related eukaryotes.
door: Evie R. Hodgson (21866946)
Gepubliceerd in: (2025)

Depletion of most candidate CIA pathway proteins leads to a decrease in protein translation in <i>Toxoplasma gondii</i> parasites.
door: Evie R. Hodgson (21866946)
Gepubliceerd in: (2025)

The CD5 loop of <i>Tg</i>CIA1 is sufficient for mitochondrial targeting, with the positioning of the loop important for <i>Tg</i>CIA1 function.
door: Evie R. Hodgson (21866946)
Gepubliceerd in: (2025)

The mitochondrial localization of <i>Tg</i>CIA1 is not dependent on other candidate CIA pathway proteins.
door: Evie R. Hodgson (21866946)
Gepubliceerd in: (2025)

Epitope tagging <i>Tg</i>ABCE1 in the r<i>Tg</i>CIA1-mAID-HA and r<i>Tg</i>Dre2-mAID-HA lines.
door: Evie R. Hodgson (21866946)
Gepubliceerd in: (2025)

The effects of mutating the CD loops of <i>Tg</i>CIA1 on mitochondrial morphology and parasite proliferation.
door: Evie R. Hodgson (21866946)
Gepubliceerd in: (2025)

Multiple sequence alignment of the <i>Tg</i>CIA2 protein with homologs from other eukaryotes.
door: Evie R. Hodgson (21866946)
Gepubliceerd in: (2025)

An aromatic amino acid motif in the CD5 loop of <i>Tg</i>CIA1 facilitates mitochondrial targeting.
door: Evie R. Hodgson (21866946)
Gepubliceerd in: (2025)

An aromatic amino acid motif in the CD5 loop of <i>Tg</i>CIA1 facilitates mitochondrial targeting.
door: Evie R. Hodgson (21866946)
Gepubliceerd in: (2025)

Candidate CIA pathway proteins are important for parasite proliferation.
door: Evie R. Hodgson (21866946)
Gepubliceerd in: (2025)

The CD5 loop of the CIA1 protein is functionally conserved in myzozoans.
door: Evie R. Hodgson (21866946)
Gepubliceerd in: (2025)

The raw and normalized numerical data for the graphical figures depicted in the manuscript.
door: Evie R. Hodgson (21866946)
Gepubliceerd in: (2025)

Immunofluorescence assay controls on untagged parasites.
door: Evie R. Hodgson (21866946)
Gepubliceerd in: (2025)

<i>Toxoplasma gondii</i> tachyzoite cell organization.
door: Romuald Haase (22339777)
Gepubliceerd in: (2025)

A. Library preparation strategy: poly-A(+) RNAs are captured by complementarity to reverse transcription primer, then second strand is synthesized using random hexamers and handles for sequencing are attached through two rounds of PCR. B. Mapped read distribution by species and by biotype. C and D. Principal component analysis of mouse and <i>T. gondii</i> transcriptomes, respectively. E and F. Volcano plots of Live <i>Toxoplasma</i>-infected mouse and <i>T. gondii</i> time points, respectively. To calculate Log<sub>2</sub>(Fold change), every timepoint is compared to corresponding samples (either macrophage or <i>Toxoplasma</i>) before infection (t = 0 min). Most significant and most upregulated transcripts are labelled. Number of significantly (p ≤ 0.05) downregulated and upregulated genes for each time point is given in blue and red, respectively. In F, 24-hour time point, red dots mark ROP
door: Dominykas Murza (22676289)
Gepubliceerd in: (2025)

A. <i>T. gondii</i> gene group changes throughout the time course, expressed as log<sub>2</sub>(fold change) relative to pre-infection tachyzoites (t = 0). Grey area depicts the 95% confidence interval. n value refers to number of genes detected in each group. B. Gene set enrichment plot for most enriched terms from <i>T. gondii</i> transcriptome features at 15 min to 120 min. Five most significant terms are displayed for each database. C and D. Transcriptional profiles of top five upregulated and downregulated <i>T. gondii</i> transcription factors, respectively.
door: Dominykas Murza (22676289)
Gepubliceerd in: (2025)

<i>In silico</i> analysis of intrinsically disordered sequences (IDRs) in the SH3 domain-containing proteins in <i>F. graminearum.</i>
door: Yakubu Saddeeq Abubakar (5558399)
Gepubliceerd in: (2025)

qRT-PCR showing the expression of sexual reproduction-responsive genes in Δ<i>Fghof1</i> and Δ<i>Fgrax2</i> mutants.
door: Yakubu Saddeeq Abubakar (5558399)
Gepubliceerd in: (2025)

Defects of Δ<i>Fgcyk3</i> mutant in nuclear division.
door: Yakubu Saddeeq Abubakar (5558399)
Gepubliceerd in: (2025)

Effects of <i>FgHOF1</i> deletion on cytoskeletal and nuclear distribution.
door: Yakubu Saddeeq Abubakar (5558399)
Gepubliceerd in: (2025)

Δ<i>Fghof1</i> mutant could be compromised in cell division.
door: Yakubu Saddeeq Abubakar (5558399)
Gepubliceerd in: (2025)

Effect of SH3 domain gene deletions on the pathogenicity of <i>F. graminearum.</i>
door: Yakubu Saddeeq Abubakar (5558399)
Gepubliceerd in: (2025)

Sensitivity of Δ<i>Fghof1</i> mutant conidia to different DAPI concentrations.
door: Yakubu Saddeeq Abubakar (5558399)
Gepubliceerd in: (2025)

Subcellular localizations of SH3 domain-containing proteins in <i>F. graminearum</i> hyphae.
door: Yakubu Saddeeq Abubakar (5558399)
Gepubliceerd in: (2025)

Influence of SH3 domain-containing proteins on sexual development of <i>F. graminearum.</i>
door: Yakubu Saddeeq Abubakar (5558399)
Gepubliceerd in: (2025)

Impact of SH3 domain-containing proteins on the vegetative growth of <i>F. graminearum.</i>
door: Yakubu Saddeeq Abubakar (5558399)
Gepubliceerd in: (2025)

Abnormal Δ<i>Fghof1</i> mutant conidia also exhibit nuclear fragmentation.
door: Yakubu Saddeeq Abubakar (5558399)
Gepubliceerd in: (2025)

PCR gels showing successful deletion of SH3 genes in <i>F. graminearum.</i>
door: Yakubu Saddeeq Abubakar (5558399)
Gepubliceerd in: (2025)

SH3 domain-containing genes and the subcellular localization of their respective products in <i>F. graminearum.</i>
door: Yakubu Saddeeq Abubakar (5558399)
Gepubliceerd in: (2025)

SH3 domain-containing proteins exhibit features of phase separation in <i>F. graminearum.</i>
door: Yakubu Saddeeq Abubakar (5558399)
Gepubliceerd in: (2025)

Role of SH3 domain-containing proteins on deoxynivalenol (DON) production in <i>F. graminearum.</i>
door: Yakubu Saddeeq Abubakar (5558399)
Gepubliceerd in: (2025)

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