Localization of the CTC to the mitochondrion of <i>Toxoplasma gondii</i> is mediated by <i>Tg</i>CIA1.

Localization of the CTC to the mitochondrion of <i>Toxoplasma gondii</i> is mediated by <i>Tg</i>CIA1.

<p><b>(A–D)</b> Immunofluorescence assays of <b>(A)</b> r<i>Tg</i>CIA1-mAID-cMyc/<i>Tg</i>CIA2-HA, <b>(B)</b> r<i>Tg</i>CIA1-mAID-cMyc/<i>Tg</i>MMS19-HA, <b>(C)</b> r<i>Tg</i>CIA2-mAID-H...

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Tác giả chính:	Evie R. Hodgson (21866946) (author)
Tác giả khác:	Jenni A. Hayward (10063377) (author), Rachel A. Leonard (5195411) (author), F. Victor Makota (16625292) (author), Giel G. van Dooren (10063383) (author)
Được phát hành:	2025
Những chủ đề:	Biochemistry Medicine Microbiology Cell Biology Immunology Infectious Diseases Environmental Sciences not elsewhere classified Biological Sciences not elsewhere classified Physical Sciences not elsewhere classified iron – sulfur eukaryotic cell biology elucidates pivotal differences div >< p exhibit dual localization nuclear client proteins toxoplasma gondii </ cia targeting complex toxoplasma </ nuclear proteins gondii </ mitochondrial targeting three proteins study provides showed previously scaffold protein remained unclear present evidence otherwise ancient may reflect living relatives important group functionally conserved comprehensive analysis closest free cia1 protein
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Những quyển sách tương tự

The CIA pathway localizes to the mitochondrion of <i>Toxoplasma gondii.</i>
Bằng: Evie R. Hodgson (21866946)
Được phát hành: (2025)

An elongated CD5 loop is necessary for targeting <i>Tg</i>CIA1 to the mitochondrion of <i>Toxoplasma gondii.</i>
Bằng: Evie R. Hodgson (21866946)
Được phát hành: (2025)

Characterizing the protein composition of the CIA Targeting Complex (CTC) in <i>Toxoplasma gondii</i> parasites.
Bằng: Evie R. Hodgson (21866946)
Được phát hành: (2025)

Characterizing the protein composition of the CIA Targeting Complex (CTC) in <i>Toxoplasma gondii</i> parasites.
Bằng: Evie R. Hodgson (21866946)
Được phát hành: (2025)

The CD5 loop of <i>Tg</i>CIA1 is sufficient to target GFP to the mitochondrion.
Bằng: Evie R. Hodgson (21866946)
Được phát hành: (2025)

Epitope tagging candidate CIA pathway proteins in <i>Toxoplasma gondii.</i>
Bằng: Evie R. Hodgson (21866946)
Được phát hành: (2025)

Epitope tagging of candidate CIA pathway proteins in <i>Toxoplasma gondii.</i>
Bằng: Evie R. Hodgson (21866946)
Được phát hành: (2025)

Characterizing the effects of depleting candidate CIA pathway proteins in <i>Toxoplasma gondii</i> parasites.
Bằng: Evie R. Hodgson (21866946)
Được phát hành: (2025)

Generating IAA-regulatable strains of candidate CIA pathway proteins in <i>Toxoplasma gondii.</i>
Bằng: Evie R. Hodgson (21866946)
Được phát hành: (2025)

A model for the spatial organization and evolution of the CIA pathway in <i>Toxoplasma gondii</i> and related eukaryotes.
Bằng: Evie R. Hodgson (21866946)
Được phát hành: (2025)

Depletion of most candidate CIA pathway proteins leads to a decrease in protein translation in <i>Toxoplasma gondii</i> parasites.
Bằng: Evie R. Hodgson (21866946)
Được phát hành: (2025)

The CD5 loop of <i>Tg</i>CIA1 is sufficient for mitochondrial targeting, with the positioning of the loop important for <i>Tg</i>CIA1 function.
Bằng: Evie R. Hodgson (21866946)
Được phát hành: (2025)

The mitochondrial localization of <i>Tg</i>CIA1 is not dependent on other candidate CIA pathway proteins.
Bằng: Evie R. Hodgson (21866946)
Được phát hành: (2025)

Epitope tagging <i>Tg</i>ABCE1 in the r<i>Tg</i>CIA1-mAID-HA and r<i>Tg</i>Dre2-mAID-HA lines.
Bằng: Evie R. Hodgson (21866946)
Được phát hành: (2025)

The effects of mutating the CD loops of <i>Tg</i>CIA1 on mitochondrial morphology and parasite proliferation.
Bằng: Evie R. Hodgson (21866946)
Được phát hành: (2025)

Multiple sequence alignment of the <i>Tg</i>CIA2 protein with homologs from other eukaryotes.
Bằng: Evie R. Hodgson (21866946)
Được phát hành: (2025)

An aromatic amino acid motif in the CD5 loop of <i>Tg</i>CIA1 facilitates mitochondrial targeting.
Bằng: Evie R. Hodgson (21866946)
Được phát hành: (2025)

An aromatic amino acid motif in the CD5 loop of <i>Tg</i>CIA1 facilitates mitochondrial targeting.
Bằng: Evie R. Hodgson (21866946)
Được phát hành: (2025)

Candidate CIA pathway proteins are important for parasite proliferation.
Bằng: Evie R. Hodgson (21866946)
Được phát hành: (2025)

The CD5 loop of the CIA1 protein is functionally conserved in myzozoans.
Bằng: Evie R. Hodgson (21866946)
Được phát hành: (2025)

The raw and normalized numerical data for the graphical figures depicted in the manuscript.
Bằng: Evie R. Hodgson (21866946)
Được phát hành: (2025)

Immunofluorescence assay controls on untagged parasites.
Bằng: Evie R. Hodgson (21866946)
Được phát hành: (2025)

<i>Toxoplasma gondii</i> tachyzoite cell organization.
Bằng: Romuald Haase (22339777)
Được phát hành: (2025)

A. Library preparation strategy: poly-A(+) RNAs are captured by complementarity to reverse transcription primer, then second strand is synthesized using random hexamers and handles for sequencing are attached through two rounds of PCR. B. Mapped read distribution by species and by biotype. C and D. Principal component analysis of mouse and <i>T. gondii</i> transcriptomes, respectively. E and F. Volcano plots of Live <i>Toxoplasma</i>-infected mouse and <i>T. gondii</i> time points, respectively. To calculate Log<sub>2</sub>(Fold change), every timepoint is compared to corresponding samples (either macrophage or <i>Toxoplasma</i>) before infection (t = 0 min). Most significant and most upregulated transcripts are labelled. Number of significantly (p ≤ 0.05) downregulated and upregulated genes for each time point is given in blue and red, respectively. In F, 24-hour time point, red dots mark ROP
Bằng: Dominykas Murza (22676289)
Được phát hành: (2025)

A. <i>T. gondii</i> gene group changes throughout the time course, expressed as log<sub>2</sub>(fold change) relative to pre-infection tachyzoites (t = 0). Grey area depicts the 95% confidence interval. n value refers to number of genes detected in each group. B. Gene set enrichment plot for most enriched terms from <i>T. gondii</i> transcriptome features at 15 min to 120 min. Five most significant terms are displayed for each database. C and D. Transcriptional profiles of top five upregulated and downregulated <i>T. gondii</i> transcription factors, respectively.
Bằng: Dominykas Murza (22676289)
Được phát hành: (2025)

<i>In silico</i> analysis of intrinsically disordered sequences (IDRs) in the SH3 domain-containing proteins in <i>F. graminearum.</i>
Bằng: Yakubu Saddeeq Abubakar (5558399)
Được phát hành: (2025)

qRT-PCR showing the expression of sexual reproduction-responsive genes in Δ<i>Fghof1</i> and Δ<i>Fgrax2</i> mutants.
Bằng: Yakubu Saddeeq Abubakar (5558399)
Được phát hành: (2025)

Defects of Δ<i>Fgcyk3</i> mutant in nuclear division.
Bằng: Yakubu Saddeeq Abubakar (5558399)
Được phát hành: (2025)

Effects of <i>FgHOF1</i> deletion on cytoskeletal and nuclear distribution.
Bằng: Yakubu Saddeeq Abubakar (5558399)
Được phát hành: (2025)

Δ<i>Fghof1</i> mutant could be compromised in cell division.
Bằng: Yakubu Saddeeq Abubakar (5558399)
Được phát hành: (2025)

Effect of SH3 domain gene deletions on the pathogenicity of <i>F. graminearum.</i>
Bằng: Yakubu Saddeeq Abubakar (5558399)
Được phát hành: (2025)

Sensitivity of Δ<i>Fghof1</i> mutant conidia to different DAPI concentrations.
Bằng: Yakubu Saddeeq Abubakar (5558399)
Được phát hành: (2025)

Subcellular localizations of SH3 domain-containing proteins in <i>F. graminearum</i> hyphae.
Bằng: Yakubu Saddeeq Abubakar (5558399)
Được phát hành: (2025)

Influence of SH3 domain-containing proteins on sexual development of <i>F. graminearum.</i>
Bằng: Yakubu Saddeeq Abubakar (5558399)
Được phát hành: (2025)

Impact of SH3 domain-containing proteins on the vegetative growth of <i>F. graminearum.</i>
Bằng: Yakubu Saddeeq Abubakar (5558399)
Được phát hành: (2025)

Abnormal Δ<i>Fghof1</i> mutant conidia also exhibit nuclear fragmentation.
Bằng: Yakubu Saddeeq Abubakar (5558399)
Được phát hành: (2025)

PCR gels showing successful deletion of SH3 genes in <i>F. graminearum.</i>
Bằng: Yakubu Saddeeq Abubakar (5558399)
Được phát hành: (2025)

SH3 domain-containing genes and the subcellular localization of their respective products in <i>F. graminearum.</i>
Bằng: Yakubu Saddeeq Abubakar (5558399)
Được phát hành: (2025)

SH3 domain-containing proteins exhibit features of phase separation in <i>F. graminearum.</i>
Bằng: Yakubu Saddeeq Abubakar (5558399)
Được phát hành: (2025)

Role of SH3 domain-containing proteins on deoxynivalenol (DON) production in <i>F. graminearum.</i>
Bằng: Yakubu Saddeeq Abubakar (5558399)
Được phát hành: (2025)

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