Microscopic agglutination test results.
<div><p>Background</p><p>Leptospirosis is a zoonotic disease of increasing importance in French Guiana. It particularly affects subjects living in precarious conditions. We aimed to determine the seroprevalence and the risk of exposure to leptospirosis among inhabitants of th...
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2025
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| _version_ | 1849927641717538816 |
|---|---|
| author | Paul Le Turnier (7829654) |
| author2 | Margot Oberlis (18879250) Anne Lavergne (388844) Loïc Epelboin (458049) Mathieu Picardeau (32310) |
| author2_role | author author author author |
| author_facet | Paul Le Turnier (7829654) Margot Oberlis (18879250) Anne Lavergne (388844) Loïc Epelboin (458049) Mathieu Picardeau (32310) |
| author_role | author |
| dc.creator.none.fl_str_mv | Paul Le Turnier (7829654) Margot Oberlis (18879250) Anne Lavergne (388844) Loïc Epelboin (458049) Mathieu Picardeau (32310) |
| dc.date.none.fl_str_mv | 2025-11-24T18:33:52Z |
| dc.identifier.none.fl_str_mv | 10.1371/journal.pntd.0013764.t004 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/dataset/Microscopic_agglutination_test_results_/30697626 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Biotechnology Science Policy Infectious Diseases Virology Biological Sciences not elsewhere classified using 17 pathogenic three informal settlements microscopic agglutination test least 2 years female sex ratio 34 &# 8211 leptospirosis among inhabitants broader serological surveys 96 %), mainly household rodent exposure foot skin exposure high theoretical risk xlink "> leptospirosis leptospirosis exposure factors risk leptospirosis transmission xlink "> exposure factors serological investigation effective transmission 83 %), leptospirosis seroprevalence risk occupation risk exposures zoonotic disease wet environments water sources volunteers aged standardized questionnaire reactivity threshold reactive serum precarious conditions may suggest main serogroups main city leptospira </ increasing importance french guiana environmental studies collective standpoint 92 %) 89 %) 82 %). |
| dc.title.none.fl_str_mv | Microscopic agglutination test results. |
| dc.type.none.fl_str_mv | Dataset info:eu-repo/semantics/publishedVersion dataset |
| description | <div><p>Background</p><p>Leptospirosis is a zoonotic disease of increasing importance in French Guiana. It particularly affects subjects living in precarious conditions. We aimed to determine the seroprevalence and the risk of exposure to leptospirosis among inhabitants of three informal settlements in French Guiana.</p><p>Methods</p><p>A serological investigation was conducted in 2022 in three informal settlements in the area of Cayenne, the main city of French Guiana. Leptospirosis exposure factors were assessed in volunteers aged > 15 through a standardized questionnaire. Leptospirosis seroprevalence was evaluated with Microscopic Agglutination Test (MAT) using 17 pathogenic <i>Leptospira</i> antigens with a reactivity threshold of 1:100.</p><p>Results</p><p>In 266 participants, median [IQR] age was 42 [34–52] and male to female sex ratio was 0.9. Most participants were migrants (96%), mainly from Haiti (83%), and lived in the study area for at least 2 years (82%). Household rodent exposure (89%) and use of other water sources than collective standpoint (92%) were common. An at-risk occupation was reported for 68% of working participants. Leptospirosis seroprevalence was 7.5% (95% CI [4.7-11.4]) with Ballum and Icterohaemorrhagiae as the main serogroups. Foot skin exposure in wet environments was associated with reactive serum (OR 7.6, 95% CI [1.1 - 326.7]).</p><p>Conclusion</p><p>Despite a high theoretical risk of leptospirosis exposure among informal settlements inhabitants, only a few participants were seroreactive for <i>Leptospira</i>. This may suggest that despite at-risk exposures the effective transmission of leptospirosis remains limited within the study area. Broader serological surveys and environmental studies should clarify the areas of at-risk leptospirosis transmission in French Guiana.</p></div> |
| eu_rights_str_mv | openAccess |
| id | Manara_615b6dba04353f2e5333ee86857433d6 |
| identifier_str_mv | 10.1371/journal.pntd.0013764.t004 |
| network_acronym_str | Manara |
| network_name_str | ManaraRepo |
| oai_identifier_str | oai:figshare.com:article/30697626 |
| publishDate | 2025 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | Microscopic agglutination test results.Paul Le Turnier (7829654)Margot Oberlis (18879250)Anne Lavergne (388844)Loïc Epelboin (458049)Mathieu Picardeau (32310)BiotechnologyScience PolicyInfectious DiseasesVirologyBiological Sciences not elsewhere classifiedusing 17 pathogenicthree informal settlementsmicroscopic agglutination testleast 2 yearsfemale sex ratio34 &# 8211leptospirosis among inhabitantsbroader serological surveys96 %), mainlyhousehold rodent exposurefoot skin exposurehigh theoretical riskxlink "> leptospirosisleptospirosis exposure factorsrisk leptospirosis transmissionxlink ">exposure factorsserological investigationeffective transmission83 %),leptospirosis seroprevalencerisk occupationrisk exposureszoonotic diseasewet environmentswater sourcesvolunteers agedstandardized questionnairereactivity thresholdreactive serumprecarious conditionsmay suggestmain serogroupsmain cityleptospira </increasing importancefrench guianaenvironmental studiescollective standpoint92 %)89 %)82 %).<div><p>Background</p><p>Leptospirosis is a zoonotic disease of increasing importance in French Guiana. It particularly affects subjects living in precarious conditions. We aimed to determine the seroprevalence and the risk of exposure to leptospirosis among inhabitants of three informal settlements in French Guiana.</p><p>Methods</p><p>A serological investigation was conducted in 2022 in three informal settlements in the area of Cayenne, the main city of French Guiana. Leptospirosis exposure factors were assessed in volunteers aged > 15 through a standardized questionnaire. Leptospirosis seroprevalence was evaluated with Microscopic Agglutination Test (MAT) using 17 pathogenic <i>Leptospira</i> antigens with a reactivity threshold of 1:100.</p><p>Results</p><p>In 266 participants, median [IQR] age was 42 [34–52] and male to female sex ratio was 0.9. Most participants were migrants (96%), mainly from Haiti (83%), and lived in the study area for at least 2 years (82%). Household rodent exposure (89%) and use of other water sources than collective standpoint (92%) were common. An at-risk occupation was reported for 68% of working participants. Leptospirosis seroprevalence was 7.5% (95% CI [4.7-11.4]) with Ballum and Icterohaemorrhagiae as the main serogroups. Foot skin exposure in wet environments was associated with reactive serum (OR 7.6, 95% CI [1.1 - 326.7]).</p><p>Conclusion</p><p>Despite a high theoretical risk of leptospirosis exposure among informal settlements inhabitants, only a few participants were seroreactive for <i>Leptospira</i>. This may suggest that despite at-risk exposures the effective transmission of leptospirosis remains limited within the study area. Broader serological surveys and environmental studies should clarify the areas of at-risk leptospirosis transmission in French Guiana.</p></div>2025-11-24T18:33:52ZDatasetinfo:eu-repo/semantics/publishedVersiondataset10.1371/journal.pntd.0013764.t004https://figshare.com/articles/dataset/Microscopic_agglutination_test_results_/30697626CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/306976262025-11-24T18:33:52Z |
| spellingShingle | Microscopic agglutination test results. Paul Le Turnier (7829654) Biotechnology Science Policy Infectious Diseases Virology Biological Sciences not elsewhere classified using 17 pathogenic three informal settlements microscopic agglutination test least 2 years female sex ratio 34 &# 8211 leptospirosis among inhabitants broader serological surveys 96 %), mainly household rodent exposure foot skin exposure high theoretical risk xlink "> leptospirosis leptospirosis exposure factors risk leptospirosis transmission xlink "> exposure factors serological investigation effective transmission 83 %), leptospirosis seroprevalence risk occupation risk exposures zoonotic disease wet environments water sources volunteers aged standardized questionnaire reactivity threshold reactive serum precarious conditions may suggest main serogroups main city leptospira </ increasing importance french guiana environmental studies collective standpoint 92 %) 89 %) 82 %). |
| status_str | publishedVersion |
| title | Microscopic agglutination test results. |
| title_full | Microscopic agglutination test results. |
| title_fullStr | Microscopic agglutination test results. |
| title_full_unstemmed | Microscopic agglutination test results. |
| title_short | Microscopic agglutination test results. |
| title_sort | Microscopic agglutination test results. |
| topic | Biotechnology Science Policy Infectious Diseases Virology Biological Sciences not elsewhere classified using 17 pathogenic three informal settlements microscopic agglutination test least 2 years female sex ratio 34 &# 8211 leptospirosis among inhabitants broader serological surveys 96 %), mainly household rodent exposure foot skin exposure high theoretical risk xlink "> leptospirosis leptospirosis exposure factors risk leptospirosis transmission xlink "> exposure factors serological investigation effective transmission 83 %), leptospirosis seroprevalence risk occupation risk exposures zoonotic disease wet environments water sources volunteers aged standardized questionnaire reactivity threshold reactive serum precarious conditions may suggest main serogroups main city leptospira </ increasing importance french guiana environmental studies collective standpoint 92 %) 89 %) 82 %). |