Figure S1 from T-cell Receptor Therapy Targeting Mutant Capicua Transcriptional Repressor in Experimental Gliomas
<p>Supplementary Figure 1: T cell responses in A2.DR1 and DR4 mice after peptide vaccination with potential shared neoepitopes. A. Predicted binding affinity for selected amino acid alterations for HLA-A*0201 determined by NetMHC 4.0. B, C. Quantification of IFN-γ ELISpot using cells isolated...
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2025
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| Tóm tắt: | <p>Supplementary Figure 1: T cell responses in A2.DR1 and DR4 mice after peptide vaccination with potential shared neoepitopes. A. Predicted binding affinity for selected amino acid alterations for HLA-A*0201 determined by NetMHC 4.0. B, C. Quantification of IFN-γ ELISpot using cells isolated from lymph nodes from vaccinated A2.DR1 mice restimulated with the indicated peptide. D. ELISpot of splenocytes from 27-mer CICR215W-vaccinated mice restimulated for 48 h with the indicated 15-mer (see also Supplementary Table 1). B, C, D Data are represented as mean {plus minus} SEM, statistical significance was determined by unpaired two-tailed Student's t-test. E. Intracellular IFN-γ flow cytometric analyses after in vitro re-stimulation of splenocytes from 27-mer CICR215W-vaccinated DR4 mice gated on single, living, and CD3+ cells.</p> |
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