Potent phenolics with antimigratory and anti-MRSA powers from fungus associated with <i>Saussurea involucrata</i>

Potent phenolics with antimigratory and anti-MRSA powers from fungus associated with <i>Saussurea involucrata</i>

<p>Seven phenolics were isolated from the endophytic fungus <i>Alternaria sp</i>. associated with <i>Saussurea involucrata</i>. The structures were identified as (±)-Dehydroaltenusin (1), Alterlactone (2), Altenuene (3), Djalonensone (4), 1-Deoxyrubralactone (5), Altert...

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Bibliografiske detaljer
Hovedforfatter: Wei-hua Yuan (22683169) (author)
Andre forfattere: Meng-ting Teng (22683172) (author), Lin Ma (23007) (author), Yan-feng Wan (22683175) (author), Kai-yue Lu (22683178) (author), Yan-hui Shi (22683181) (author), Peng Zhang (2071) (author)
Udgivet: 2025
Fag:
Biochemistry
Microbiology
Pharmacology
Biotechnology
Ecology
Cancer
Hematology
Biological Sciences not elsewhere classified
Chemical Sciences not elsewhere classified
Physical Sciences not elsewhere classified
Saussurea involucrata
endophytic fungus
anti-MRSA
antitumor
antioxidant
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Summary:<p>Seven phenolics were isolated from the endophytic fungus <i>Alternaria sp</i>. associated with <i>Saussurea involucrata</i>. The structures were identified as (±)-Dehydroaltenusin (1), Alterlactone (2), Altenuene (3), Djalonensone (4), 1-Deoxyrubralactone (5), Altertenuol (6), and Alternariol (7) respectively by a combination of spectroscopic and single-crystal X-ray diffraction analysis. Compound 1 showed obvious antimigratory activity against MCF-7 cells. Compound 2 showed potent antibacterial activities against a resistant bacterium <i>Staphilococcus aureus</i> 5 (MRSA). Meanwhile the cytotoxic, antioxidant were also evaluated.</p>

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