Dearomative 1,4-Difunctionalization of Non-Activated Arenes Enabled by Boryl Radical-Mediated Halogen-Atom Transfer

Dearomative 1,4-Difunctionalization of Non-Activated Arenes Enabled by Boryl Radical-Mediated Halogen-Atom Transfer

Given the widespread presence of spirocyclic scaffolds in natural products and pharmacologically relevant synthetic compounds, the development of efficient methodologies for their construction holds great importance in medicinal chemistry and pharmaceutical research. In this study, a general photoch...

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Bibliographic Details
Main Author: Congling Deng (20523059) (author)
Other Authors: Hao Wu (65943) (author), Sheng Li (107261) (author), Li Chen (5749) (author), Xiaozu Liu (2078776) (author), Peijun Liu (563547) (author)
Published: 2025
Subjects:
Biochemistry
Microbiology
Pharmacology
Ecology
Developmental Biology
Inorganic Chemistry
Plant Biology
Chemical Sciences not elsewhere classified
subsequent chemodivergent transformations
formal total synthesis
activate aryl bromides
structurally diverse 1
iodides via halogen
activated arenes enabled
corresponding aryl radicals
atom transfer given
atom transfer
aryl halides
nonactivated arenes
mediated halogen
dearomative 1
borane radicals
widespread presence
thereby allowing
spirocyclic scaffolds
remarkable compatibility
rapid assembly
potential utility
pharmaceutical research
natural products
method lies
medicinal chemistry
efficient methodologies
dihydrobenzofuran subunits
boryl radical
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