Dearomative 1,4-Difunctionalization of Non-Activated Arenes Enabled by Boryl Radical-Mediated Halogen-Atom Transfer

Given the widespread presence of spirocyclic scaffolds in natural products and pharmacologically relevant synthetic compounds, the development of efficient methodologies for their construction holds great importance in medicinal chemistry and pharmaceutical research. In this study, a general photoch...

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Bibliographic Details
Main Author:	Congling Deng (20523059) (author)
Other Authors:	Hao Wu (65943) (author), Sheng Li (107261) (author), Li Chen (5749) (author), Xiaozu Liu (2078776) (author), Peijun Liu (563547) (author)
Published:	2025
Subjects:	Biochemistry Microbiology Pharmacology Ecology Developmental Biology Inorganic Chemistry Plant Biology Chemical Sciences not elsewhere classified subsequent chemodivergent transformations formal total synthesis activate aryl bromides structurally diverse 1 iodides via halogen activated arenes enabled corresponding aryl radicals atom transfer given atom transfer aryl halides nonactivated arenes mediated halogen dearomative 1 borane radicals widespread presence thereby allowing spirocyclic scaffolds remarkable compatibility rapid assembly potential utility pharmaceutical research natural products method lies medicinal chemistry efficient methodologies dihydrobenzofuran subunits boryl radical
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Dearomative 1,4-Difunctionalization of Non-Activated Arenes Enabled by Boryl Radical-Mediated Halogen-Atom Transfer

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