Spearman correlation analysis between gut microbial taxa and circulating metabolites, detailing correlation coefficients, significance values, and taxon–metabolite pairings indicative of microbiome–host metabolic interactions.

Spearman correlation analysis between gut microbial taxa and circulating metabolites, detailing correlation coefficients, significance values, and taxon–metabolite pairings indicative of microbiome–host metabolic interactions.

<p>Spearman correlation analysis between gut microbial taxa and circulating metabolites, detailing correlation coefficients, significance values, and taxon–metabolite pairings indicative of microbiome–host metabolic interactions.</p>

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Dettagli Bibliografici
Autore principale: Ji-Xin Zhao (22056386) (author)
Altri autori: Wen-Bin Zheng (3328680) (author), Shi-Chen Xie (10678094) (author), He Ma (583317) (author), Xiao-Tong Chen (4217488) (author), Ying-Qian Gao (22683622) (author), Lu-Yao Tang (22683625) (author), Meng-Ting Yang (10714266) (author), Fu-Long Nan (22056395) (author), Jing Jiang (130103) (author), Hany M. Elsheikha (6910232) (author), Xiao-Xuan Zhang (610969) (author)
Pubblicazione: 2025
Soggetti:
Biochemistry
Microbiology
Cell Biology
Genetics
Physiology
Ecology
Immunology
Computational Biology
Biological Sciences not elsewhere classified
Chemical Sciences not elsewhere classified
showed negative associations
quality reads produced
oxidative stress response
conducted metagenomic sequencing
compositional changes coincided
bile acid transformation
aromatic compound processing
7 million genes
rothia nasimurium </
lactobacillus intestinalis </
de novo </
untargeted serum metabolomics
specific metabolic disruptions
amino acid metabolism
toxoplasma gondii </
limosilactobacillus reuteri </
lactobacillus johnsonii </
akkermansia muciniphila </
host systemic metabolism
disrupts intestinal microbiota
reuteri </
muciniphila </
johnsonii </
gondii </
host metabolism
untargeted lc
metabolic targets
energy metabolism
infection disrupts
significant shifts
reduced abundance
rat model
positively correlated
pathways related
novel microbial
microbial diversity
metabolites implicated
marked reduction
marked depletion
key role
immune modulation
gut microbiota
findings demonstrate
enhanced glycan
disease mechanisms
comprehensive non
community structure
chronic stages
active enzymes
18 sprague
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