CASynergy algorithm workflow.
<p><b>(a)</b> Cell line-specific gene network extraction module: Using the expression data of key genes in the cell line and the PPI network , a disease-specific topological network is constructed; <b>(b)</b> Drug and cell line feature extraction and fusion module: The...
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2025
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| Summary: | <p><b>(a)</b> Cell line-specific gene network extraction module: Using the expression data of key genes in the cell line and the PPI network , a disease-specific topological network is constructed; <b>(b)</b> Drug and cell line feature extraction and fusion module: The fusion of drug combination features and disease cell line features forms a semantic network; <b>(c)</b> Drug combination synergy prediction module based on causal attention learning: By combining the topological and semantic networks, and utilizing a causal inference-based attention mechanism, the synergy of drug combinations is predicted.</p> |
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