Supplementary Figure S6 from Serologic Profiling Using an Epstein-Barr Virus Mammalian Expression Library Identifies EBNA1 IgA as a Prediagnostic Marker for Nasopharyngeal Carcinoma
<p>EBNA1 protein sequences from NPC tumors compared to the Akata or B95-8 reference strains. Conservation plots of EBNA1 amino acid sequences comparing NPC tumors to Akata (left column) and B95-8 (right column). The NPC tumor-derived sequences are grouped by geographic region (endemic - China,...
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| Achoimre: | <p>EBNA1 protein sequences from NPC tumors compared to the Akata or B95-8 reference strains. Conservation plots of EBNA1 amino acid sequences comparing NPC tumors to Akata (left column) and B95-8 (right column). The NPC tumor-derived sequences are grouped by geographic region (endemic - China, Hong Kong, and Indonesia; non-endemic China). The number of tumor-derived sequences included in each alignment are shown in parentheses. EBNA1 regions of interest are labeled – N-Terminus, Glycine-Alanine repeat region (Gly-Ala Repeat), Nuclear Localization Signal (NLS), Immunodominant Epitope (IDE), DNA Binding Domain (DBD), Dimerization Motif (Dimer 1 and 2). Red arrows denote residues that are deviant from the reference strain in the IDE.</p> |
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