Panx1 deletion in LECs enhances advanced atherosclerosis in aortic roots of female mice.
<p>Body weight (A), serum cholesterol (B), LDL (C), HDL (D), TG (E) and FFA (F) levels of female control <i>Panx1</i><sup><i>fl/fl</i></sup><i>Apoe</i><sup><i>-/-</i></sup> mice (white) and female <i>Panx1</i>&...
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2024
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| Summary: | <p>Body weight (A), serum cholesterol (B), LDL (C), HDL (D), TG (E) and FFA (F) levels of female control <i>Panx1</i><sup><i>fl/fl</i></sup><i>Apoe</i><sup><i>-/-</i></sup> mice (white) and female <i>Panx1</i><sup><i>LECdel</i></sup><i>Apoe</i><sup><i>-/-</i></sup> mice (grey) after 10 weeks of HCD. Sudan-IV staining (E) and quantification of atherosclerotic lesion burden in thoraco-abdominal aortas (F) of male <i>Panx1</i><sup><i>fl/fl</i></sup><i>Apoe</i><sup><i>-/-</i></sup> mice (white) and male <i>Panx1</i><sup><i>LECdel</i></sup><i>Apoe</i><sup><i>-/-</i></sup> mice (grey) after 10 weeks of HCD. Mean ± SEM, N = 8–9, *<i>P</i>≤0.05, **<i>P</i>≤0.01, ***<i>P</i>≤0.001, ****<i>P</i>≤0.0001.</p> |
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