Modelling framework for TMS-induced long-term synaptic plasticity.
<p>The Neuron Modeling for TMS (<i>NeMo-TMS</i>) toolbox integrates detailed neuronal models with TMS-induced electric fields, allowing the simulation of cellular and subcellular voltage and calcium responses during single and repetitive TMS pulses [<a href="http://www.plos...
محفوظ في:
| المؤلف الرئيسي: | |
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| مؤلفون آخرون: | , , , , , |
| منشور في: |
2025
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| الموضوعات: | |
| الوسوم: |
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| الملخص: | <p>The Neuron Modeling for TMS (<i>NeMo-TMS</i>) toolbox integrates detailed neuronal models with TMS-induced electric fields, allowing the simulation of cellular and subcellular voltage and calcium responses during single and repetitive TMS pulses [<a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1012295#pcbi.1012295.ref034" target="_blank">34</a>]. The direction of the electric field is represented by the vector E. We implement in <i>NeMo-TMS</i> a validated model of a CA1 pyramidal cell with detailed biophysics and reduced morphology, capable of generating realistic dendritic and somatic spikes [<a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1012295#pcbi.1012295.ref035" target="_blank">35</a>,<a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1012295#pcbi.1012295.ref043" target="_blank">43</a>]. Relative dendritic diameters are depicted. We introduced a unified voltage-dependent 4-pathway (pre- and postsynaptic; LTP and LTD) model of long-term synaptic plasticity (yellow circle with pre- and postsynaptic LTP (+) and LTD(-)), capable of reproducing the frequency-, timing- and location-dependence of synaptic changes [<a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1012295#pcbi.1012295.ref030" target="_blank">30</a>], into the existing <i>NeMo-TMS</i> framework. 128 of plastic excitatory synapses were placed in the morphology.</p> |
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