Table 1_Independent component analysis of resting-state fMRI identifies regions associated with seizure freedom after laser interstitial thermal therapy for temporal lobe epilepsy.docx
Objective<p>Temporal lobe epilepsy (TLE) is a common form of drug-resistant epilepsy often treated with surgical interventions, including laser interstitial thermal therapy (LITT). However, patient-specific factors influencing LITT outcomes remain unclear. This retrospective study aimed to ide...
Na minha lista:
| Autor principal: | |
|---|---|
| Outros Autores: | , , , , , , , |
| Publicado em: |
2025
|
| Assuntos: | |
| Tags: |
Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!
|
| _version_ | 1849927637042987008 |
|---|---|
| author | Mahdi Alizadeh (13255536) |
| author2 | Jingya Miao (484248) Caio M. Matias (10227935) Kevin J. Hines (1930999) Christopher T. Skidmore (10705395) Michael R. Sperling (8613432) Joseph I. Tracy (3171207) Ashwini Sharan (608489) Chengyuan Wu (1504768) |
| author2_role | author author author author author author author author |
| author_facet | Mahdi Alizadeh (13255536) Jingya Miao (484248) Caio M. Matias (10227935) Kevin J. Hines (1930999) Christopher T. Skidmore (10705395) Michael R. Sperling (8613432) Joseph I. Tracy (3171207) Ashwini Sharan (608489) Chengyuan Wu (1504768) |
| author_role | author |
| dc.creator.none.fl_str_mv | Mahdi Alizadeh (13255536) Jingya Miao (484248) Caio M. Matias (10227935) Kevin J. Hines (1930999) Christopher T. Skidmore (10705395) Michael R. Sperling (8613432) Joseph I. Tracy (3171207) Ashwini Sharan (608489) Chengyuan Wu (1504768) |
| dc.date.none.fl_str_mv | 2025-11-25T05:10:44Z |
| dc.identifier.none.fl_str_mv | 10.3389/fneur.2025.1675066.s001 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/dataset/Table_1_Independent_component_analysis_of_resting-state_fMRI_identifies_regions_associated_with_seizure_freedom_after_laser_interstitial_thermal_therapy_for_temporal_lobe_epilepsy_docx/30703331 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Neurology and Neuromuscular Diseases temporal lobe epilepsy LITT resting state fMRI seizure freedom |
| dc.title.none.fl_str_mv | Table 1_Independent component analysis of resting-state fMRI identifies regions associated with seizure freedom after laser interstitial thermal therapy for temporal lobe epilepsy.docx |
| dc.type.none.fl_str_mv | Dataset info:eu-repo/semantics/publishedVersion dataset |
| description | Objective<p>Temporal lobe epilepsy (TLE) is a common form of drug-resistant epilepsy often treated with surgical interventions, including laser interstitial thermal therapy (LITT). However, patient-specific factors influencing LITT outcomes remain unclear. This retrospective study aimed to identify pre-operative resting-state functional MRI (rs-fMRI) patterns associated with seizure freedom following LITT in mesial TLE.</p>Methods<p>We analyzed rs-fMRI data from 28 patients with mesial TLE who underwent LITT, classifying them into seizure-free (SF) and not seizure-free (NSF) groups based on 12-month post-operative outcomes. Independent component analysis (ICA) was used to identify subject-specific brain networks, and generalized linear models (GLM) were employed to assess associations between pre-operative spatial patterns of ICA-derived functional connectivity (FC) and surgical outcomes, controlling for clinical variables.</p>Results<p>Significant differences in brain ICA-derived FC patterns were observed between SF and NSF groups, with SF exhibiting more locally distributed ICA-derived FC patterns around the mesial temporal lobe, including the posterior orbitofrontal cortex (OFC) and anterior parahippocampal gyrus (PHG). In contrast, NSF demonstrated more diffusely distributed ICA-derived FC patterns encompassing the insula and thalami.</p>Significance<p>These findings highlight the potential of pre-operative rs-fMRI as a prognostic tool for identifying TLE patients more likely to benefit from LITT. Further validation in larger cohorts is warranted to confirm these results and optimize patient selection for surgical interventions.</p> |
| eu_rights_str_mv | openAccess |
| id | Manara_6d861080b2637ce1c56c8e44b67105bb |
| identifier_str_mv | 10.3389/fneur.2025.1675066.s001 |
| network_acronym_str | Manara |
| network_name_str | ManaraRepo |
| oai_identifier_str | oai:figshare.com:article/30703331 |
| publishDate | 2025 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | Table 1_Independent component analysis of resting-state fMRI identifies regions associated with seizure freedom after laser interstitial thermal therapy for temporal lobe epilepsy.docxMahdi Alizadeh (13255536)Jingya Miao (484248)Caio M. Matias (10227935)Kevin J. Hines (1930999)Christopher T. Skidmore (10705395)Michael R. Sperling (8613432)Joseph I. Tracy (3171207)Ashwini Sharan (608489)Chengyuan Wu (1504768)Neurology and Neuromuscular Diseasestemporal lobeepilepsyLITTresting state fMRIseizure freedomObjective<p>Temporal lobe epilepsy (TLE) is a common form of drug-resistant epilepsy often treated with surgical interventions, including laser interstitial thermal therapy (LITT). However, patient-specific factors influencing LITT outcomes remain unclear. This retrospective study aimed to identify pre-operative resting-state functional MRI (rs-fMRI) patterns associated with seizure freedom following LITT in mesial TLE.</p>Methods<p>We analyzed rs-fMRI data from 28 patients with mesial TLE who underwent LITT, classifying them into seizure-free (SF) and not seizure-free (NSF) groups based on 12-month post-operative outcomes. Independent component analysis (ICA) was used to identify subject-specific brain networks, and generalized linear models (GLM) were employed to assess associations between pre-operative spatial patterns of ICA-derived functional connectivity (FC) and surgical outcomes, controlling for clinical variables.</p>Results<p>Significant differences in brain ICA-derived FC patterns were observed between SF and NSF groups, with SF exhibiting more locally distributed ICA-derived FC patterns around the mesial temporal lobe, including the posterior orbitofrontal cortex (OFC) and anterior parahippocampal gyrus (PHG). In contrast, NSF demonstrated more diffusely distributed ICA-derived FC patterns encompassing the insula and thalami.</p>Significance<p>These findings highlight the potential of pre-operative rs-fMRI as a prognostic tool for identifying TLE patients more likely to benefit from LITT. Further validation in larger cohorts is warranted to confirm these results and optimize patient selection for surgical interventions.</p>2025-11-25T05:10:44ZDatasetinfo:eu-repo/semantics/publishedVersiondataset10.3389/fneur.2025.1675066.s001https://figshare.com/articles/dataset/Table_1_Independent_component_analysis_of_resting-state_fMRI_identifies_regions_associated_with_seizure_freedom_after_laser_interstitial_thermal_therapy_for_temporal_lobe_epilepsy_docx/30703331CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/307033312025-11-25T05:10:44Z |
| spellingShingle | Table 1_Independent component analysis of resting-state fMRI identifies regions associated with seizure freedom after laser interstitial thermal therapy for temporal lobe epilepsy.docx Mahdi Alizadeh (13255536) Neurology and Neuromuscular Diseases temporal lobe epilepsy LITT resting state fMRI seizure freedom |
| status_str | publishedVersion |
| title | Table 1_Independent component analysis of resting-state fMRI identifies regions associated with seizure freedom after laser interstitial thermal therapy for temporal lobe epilepsy.docx |
| title_full | Table 1_Independent component analysis of resting-state fMRI identifies regions associated with seizure freedom after laser interstitial thermal therapy for temporal lobe epilepsy.docx |
| title_fullStr | Table 1_Independent component analysis of resting-state fMRI identifies regions associated with seizure freedom after laser interstitial thermal therapy for temporal lobe epilepsy.docx |
| title_full_unstemmed | Table 1_Independent component analysis of resting-state fMRI identifies regions associated with seizure freedom after laser interstitial thermal therapy for temporal lobe epilepsy.docx |
| title_short | Table 1_Independent component analysis of resting-state fMRI identifies regions associated with seizure freedom after laser interstitial thermal therapy for temporal lobe epilepsy.docx |
| title_sort | Table 1_Independent component analysis of resting-state fMRI identifies regions associated with seizure freedom after laser interstitial thermal therapy for temporal lobe epilepsy.docx |
| topic | Neurology and Neuromuscular Diseases temporal lobe epilepsy LITT resting state fMRI seizure freedom |