Molecular Interactions of Fluoroquinolone Antibiotics with Lipid Membranes

Molecular Interactions of Fluoroquinolone Antibiotics with Lipid Membranes

Levofloxacin is a broad-spectrum fluoroquinolone antibiotic in clinical use that targets DNA gyrase in the cytosol. It is used in systemic applications via oral or intravenous route, and its pharmacokinetics and access to its molecular targets are strongly influenced by interactions with cellular me...

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Bibliographic Details
Main Author: D. Ralph (19979967) (author)
Other Authors: A. Goode (22767051) (author), V. Yeh (22767054) (author), J. M. A. Blair (22767057) (author), P. Williams (1634566) (author), B. B. Bonev (22767060) (author)
Published: 2025
Subjects:
Biophysics
Biochemistry
Medicine
Biotechnology
Virology
Computational Biology
Chemical Sciences not elsewhere classified
Physical Sciences not elsewhere classified
using zwitterionic dopc
negatively charged dopc
negatively charged bilayers
targets dna gyrase
monomeric soluble population
spectrum fluoroquinolone antibiotic
molecular population embedded
fractional membrane insertion
dopg lipid membranes
associated molecular assemblies
lipid membranes levofloxacin
fast exchange equilibrium
molecular targets
lipid membranes
associated population
solvated population
lipid bilayer
fluoroquinolone antibiotics
cellular membranes
antibiotic concentration
strongly influenced
solubility limits
solubility limit
physical state
observe concentration
negative lipids
molecular interactions
membrane charge
md simulations
levofloxacin solutions
intravenous route
clinical use
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