Molecular Interactions of Fluoroquinolone Antibiotics with Lipid Membranes

Levofloxacin is a broad-spectrum fluoroquinolone antibiotic in clinical use that targets DNA gyrase in the cytosol. It is used in systemic applications via oral or intravenous route, and its pharmacokinetics and access to its molecular targets are strongly influenced by interactions with cellular me...

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Bibliographic Details
Main Author:	D. Ralph (19979967) (author)
Other Authors:	A. Goode (22767051) (author), V. Yeh (22767054) (author), J. M. A. Blair (22767057) (author), P. Williams (1634566) (author), B. B. Bonev (22767060) (author)
Published:	2025
Subjects:	Biophysics Biochemistry Medicine Biotechnology Virology Computational Biology Chemical Sciences not elsewhere classified Physical Sciences not elsewhere classified using zwitterionic dopc negatively charged dopc negatively charged bilayers targets dna gyrase monomeric soluble population spectrum fluoroquinolone antibiotic molecular population embedded fractional membrane insertion dopg lipid membranes associated molecular assemblies lipid membranes levofloxacin fast exchange equilibrium molecular targets lipid membranes associated population solvated population lipid bilayer fluoroquinolone antibiotics cellular membranes antibiotic concentration strongly influenced solubility limits solubility limit physical state observe concentration negative lipids molecular interactions membrane charge md simulations levofloxacin solutions intravenous route clinical use
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Molecular Interactions of Fluoroquinolone Antibiotics with Lipid Membranes

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