MSEW attenuates reward-seeking behavior in male DO mice.

<p>(A) In male DO mice, exposure to MSEW reduced the average rate of responding on a lever paired with food reward (FR 3) during 40-min sessions. (B) During an initial extinction session (day 1 of 5), MSEW reduced lever-pressing in male DO mice relative to male NS mice. Exposure to MSEW did no...

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Main Author:	Jennifer Nguyen (3521903) (author)
Other Authors:	Kevin Shimizu (22189972) (author), Varvara Zlotnik (22189975) (author), Matthew N. Nguyen (22189978) (author), Sandra Del Toro (22189981) (author), Michael T. Nguyen (4446109) (author), Janet Ronquillo (22189984) (author), Lindsay R. Halladay (22189987) (author)
Published:	2025
Subjects:	Genetics Neuroscience Evolutionary Biology Ecology Science Policy Environmental Sciences not elsewhere classified Biological Sciences not elsewhere classified xlink "> understanding translational research focuses preclinical studies rely one key area inbred mouse strains following acute stress eight founder strains advancing translational neuroscience early life trauma early life adversity identify behavioral domains exhibit broad genetic related outcomes relevant msew produces distinct evoked fear expression early weaning related changes outcomes produced genetic complexity fear learning behavioral consequences test msew social behavior rodent models results revealed population derived phenotypic heterogeneity paraventricular nucleus msew ), maternal separation like behavior human populations findings highlight developmental factors deficits stemming childhood neglect
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MSEW attenuates reward-seeking behavior in male DO mice.

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