Deletion of the C-terminus of ATR leads to DNA damage and an increase of aberrant cells.

<p>(A - B) Western analysis of whole cell extracts from mycATR and mycATRΔC-/- cells. Cells were left untreated (NT) or treated with 0.5 mM of Hydroxyurea (HU) for 20 hours (Chronic) or treated with 5 mM of Hydroxyurea (HU) for 5 hours (Acute), washed and resuspended in fresh media. The sample...

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Bibliografiske detaljer
Hovedforfatter:	Gabriel L. A. da Silva (22676649) (author)
Andre forfattere:	Jeziel D. Damasceno (9073663) (author), Jennifer A. Black (14411790) (author), Craig Lapsley (6082646) (author), Richard McCulloch (12918) (author), Luiz R. O. Tosi (9073666) (author)
Udgivet:	2025
Fag:	Biophysics Biochemistry Microbiology Cell Biology Genetics Molecular Biology Developmental Biology Science Policy Infectious Diseases Biological Sciences not elsewhere classified Physical Sciences not elsewhere classified major &# 8217 div >< p data reveals loss cells possess mechanisms remarkably plastic genome cas9 genome editing like family acts protein kinase ataxia atr depends upon delayed dna replication stranded dna accumulation leishmania major </ dna damage kinase dna damage genome stability leishmania </ dna metabolism dna injuries atr acts replication stress replication impediments work shows whose integrity terminal knockout smaller chromosomes protozoan parasite phosphatidylinositol 3 nuclear localisation mycatrδc -/-). mycatr ), master regulator larger chromosomes key role increased levels functional relevance eukaryotic response deletion results constantly challenged atr plays atr homolog atr ),
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Deletion of the C-terminus of ATR leads to DNA damage and an increase of aberrant cells.

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