Table 1_The role of RNA methylation in glioma progression: mechanisms, diagnostic implications, and therapeutic value.docx
<p>Glioma represents a highly lethal form of malignant tumour, with RNA methylation emerging as a critical regulator of its oncogenesis and progression. As a prevalent post-translational modification, methylation influences various biological functions, particularly RNA processing, by modulati...
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| مؤلفون آخرون: | , , , |
| منشور في: |
2025
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إضافة وسم
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| _version_ | 1852020186497941504 |
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| author | Shao-Ze Zhang (7241990) |
| author2 | Shao-Yan Liu (21398519) Meng-Die Cheng (21398522) Yin-Feng Zhang (1779031) Jia-Wei Tian (10647704) |
| author2_role | author author author author |
| author_facet | Shao-Ze Zhang (7241990) Shao-Yan Liu (21398519) Meng-Die Cheng (21398522) Yin-Feng Zhang (1779031) Jia-Wei Tian (10647704) |
| author_role | author |
| dc.creator.none.fl_str_mv | Shao-Ze Zhang (7241990) Shao-Yan Liu (21398519) Meng-Die Cheng (21398522) Yin-Feng Zhang (1779031) Jia-Wei Tian (10647704) |
| dc.date.none.fl_str_mv | 2025-05-21T05:22:44Z |
| dc.identifier.none.fl_str_mv | 10.3389/fimmu.2025.1583039.s001 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/dataset/Table_1_The_role_of_RNA_methylation_in_glioma_progression_mechanisms_diagnostic_implications_and_therapeutic_value_docx/29116592 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Genetic Immunology epitranscriptome M6A m5C m7G m1A |
| dc.title.none.fl_str_mv | Table 1_The role of RNA methylation in glioma progression: mechanisms, diagnostic implications, and therapeutic value.docx |
| dc.type.none.fl_str_mv | Dataset info:eu-repo/semantics/publishedVersion dataset |
| description | <p>Glioma represents a highly lethal form of malignant tumour, with RNA methylation emerging as a critical regulator of its oncogenesis and progression. As a prevalent post-translational modification, methylation influences various biological functions, particularly RNA processing, by modulating splicing, transport, and degradation of both mRNAs and noncoding RNAs. Key methylation types such as N6-methyladenosine (m6A), N5-methylcytosine (m5C), N7-methylguanosine (m7G), and N1-methyladenosine (m1A) are dynamically regulated by specific enzymes known as writers, erasers, and readers. Dysregulation of these modifications contributes to glioma pathophysiology, while offering potential biomarkers for early detection and promising therapeutic targets. This review explores the mechanistic roles of RNA methylation in glioma and highlights its translational implications, aiming to advance molecular diagnostics and targeted interventions in glioma treatment.</p> |
| eu_rights_str_mv | openAccess |
| id | Manara_730f3794cafee5fbbd6687fb09b997ee |
| identifier_str_mv | 10.3389/fimmu.2025.1583039.s001 |
| network_acronym_str | Manara |
| network_name_str | ManaraRepo |
| oai_identifier_str | oai:figshare.com:article/29116592 |
| publishDate | 2025 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | Table 1_The role of RNA methylation in glioma progression: mechanisms, diagnostic implications, and therapeutic value.docxShao-Ze Zhang (7241990)Shao-Yan Liu (21398519)Meng-Die Cheng (21398522)Yin-Feng Zhang (1779031)Jia-Wei Tian (10647704)Genetic ImmunologyepitranscriptomeM6Am5Cm7Gm1A<p>Glioma represents a highly lethal form of malignant tumour, with RNA methylation emerging as a critical regulator of its oncogenesis and progression. As a prevalent post-translational modification, methylation influences various biological functions, particularly RNA processing, by modulating splicing, transport, and degradation of both mRNAs and noncoding RNAs. Key methylation types such as N6-methyladenosine (m6A), N5-methylcytosine (m5C), N7-methylguanosine (m7G), and N1-methyladenosine (m1A) are dynamically regulated by specific enzymes known as writers, erasers, and readers. Dysregulation of these modifications contributes to glioma pathophysiology, while offering potential biomarkers for early detection and promising therapeutic targets. This review explores the mechanistic roles of RNA methylation in glioma and highlights its translational implications, aiming to advance molecular diagnostics and targeted interventions in glioma treatment.</p>2025-05-21T05:22:44ZDatasetinfo:eu-repo/semantics/publishedVersiondataset10.3389/fimmu.2025.1583039.s001https://figshare.com/articles/dataset/Table_1_The_role_of_RNA_methylation_in_glioma_progression_mechanisms_diagnostic_implications_and_therapeutic_value_docx/29116592CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/291165922025-05-21T05:22:44Z |
| spellingShingle | Table 1_The role of RNA methylation in glioma progression: mechanisms, diagnostic implications, and therapeutic value.docx Shao-Ze Zhang (7241990) Genetic Immunology epitranscriptome M6A m5C m7G m1A |
| status_str | publishedVersion |
| title | Table 1_The role of RNA methylation in glioma progression: mechanisms, diagnostic implications, and therapeutic value.docx |
| title_full | Table 1_The role of RNA methylation in glioma progression: mechanisms, diagnostic implications, and therapeutic value.docx |
| title_fullStr | Table 1_The role of RNA methylation in glioma progression: mechanisms, diagnostic implications, and therapeutic value.docx |
| title_full_unstemmed | Table 1_The role of RNA methylation in glioma progression: mechanisms, diagnostic implications, and therapeutic value.docx |
| title_short | Table 1_The role of RNA methylation in glioma progression: mechanisms, diagnostic implications, and therapeutic value.docx |
| title_sort | Table 1_The role of RNA methylation in glioma progression: mechanisms, diagnostic implications, and therapeutic value.docx |
| topic | Genetic Immunology epitranscriptome M6A m5C m7G m1A |