The locus coeruleus maintains core body temperature and protects against hypothermia during dexmedetomidine induced sedation.

The locus coeruleus maintains core body temperature and protects against hypothermia during dexmedetomidine induced sedation.

<p dir="ltr">Dexmedetomidine (DEX), a widely used sedative in intensive care, induces an arousable state resembling non-rapid eye movement (NREM) sleep and lowers body temperature. For some patients, even slight decreases in body temperature during sedation could pose health risks. I...

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Bibliographic Details
Main Author: Berta Anuncibay (20108478) (author)
Other Authors: Ying Ma (123771) (author), Mathieu Nollet (21572777) (author), Sara Wong (19280884) (author), Giulia Miracca (8156394) (author), Daniel Rastinejad (17034378) (author), Raquel Yustos (8156397) (author), Alexei L. Vyssotski (8876525) (author), Nicholas P. Franks (1347090) (author), William Wisden (206892) (author)
Published: 2025
Subjects:
Central nervous system
sedation-induced
locus caeruleus
dexmedetomidine light sedation
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Summary:<p dir="ltr">Dexmedetomidine (DEX), a widely used sedative in intensive care, induces an arousable state resembling non-rapid eye movement (NREM) sleep and lowers body temperature. For some patients, even slight decreases in body temperature during sedation could pose health risks. It is commonly believed that DEX targets inhibitory adrenergic receptors on norepinephrinergic locus coeruleus (LC) neurons to induce sedation.</p>

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