Differential impact of EBOV and MARV on cAMP-mediated function in human gut organoids reveals region-specific loss of forskolin-induced swelling in HCOs.

Differential impact of EBOV and MARV on cAMP-mediated function in human gut organoids reveals region-specific loss of forskolin-induced swelling in HCOs.

<p>(A) iPSC-derived HIOs were infected with EBOV, EBOV-ZsGreen, or MARV at an MOI of 10 on day 35 of differentiation. At 1 dpi, HIOs were treated with 5 µM forskolin dissolved in DMSO or treated with DMSO and imaged immediately prior to treatment (0 hours, 1 dpi), and then at 24 hours (2 dpi),...

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محفوظ في:
التفاصيل البيبلوغرافية
المؤلف الرئيسي: Elizabeth Y. Flores (22676699) (author)
مؤلفون آخرون: Adam J. Hume (6107039) (author), Judith Olejnik (367849) (author), Aditya Mithal (22676702) (author), Andrew D’Amico (2248762) (author), MengWei Yang (22676705) (author), Pushpinder Bawa (733756) (author), Feiya Wang (21075016) (author), Aoife K. O’Connell (15462382) (author), Anna Tseng (20843165) (author), Nicholas A. Crossland (5500244) (author), Gustavo Mostoslavsky (110612) (author), Elke Mühlberger (45516) (author)
منشور في: 2025
الموضوعات:
Biochemistry
Microbiology
Cell Biology
Genetics
Molecular Biology
Physiology
Biotechnology
Immunology
Cancer
Mental Health
Infectious Diseases
Plant Biology
Virology
Biological Sciences not elsewhere classified
Chemical Sciences not elsewhere classified
xlink "> gastrointestinal
support viral replication
providing mechanistic insight
induced secretory diarrhea
colonic epithelial responses
model ebola virus
mediated ion transport
human gi pathology
ion transport
severe diarrhea
human ipsc
stimulated genes
specific induction
powerful system
pathogen interactions
marburg virus
junctional disruption
including apical
filovirus disease
filoviral disease
dissect host
delayed virus
colonic organoids
central contributor
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