Effective Extracellular Payload Release and Immunomodulatory Interactions govern the Therapeutic Effect of Trastuzumab Deruxtecan (T-DXd)

Immunohistochemistry assessment of tumor infiltrating T cells levels and spatial location. CD8+ (brown), CD4+ (blue) and FoxP3+ (red). Tumors were from HER2 oncogene driven transgenic mice, and treatment were administered weekly for 4 weeks, 5.4mg/kg control IgG1, 5.4mg/kg T-DXd, and 15mg/kg anti-CD...

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Main Author:	Zachary Hartman (20752724) (author)
Other Authors:	Li-Chung Tsao (20752727) (author), John Wang (20752730) (author), Xingru Ma (20752733) (author), Sirajbir Sodhi (20752736) (author), Joey Ragusa (20752739) (author), Bushanqing Liu (20752742) (author), Jason McBane (20752745) (author), Tao Wang (20752748) (author), Junping Wei (20752751) (author), Cong-Xiao Liu (20752754) (author), Xiao Yang (20752757) (author), Gangjun Lei (20752760) (author), Ivan Spasojevic (20752763) (author), Ping Fan (20752766) (author), Timothy Trotter (20752769) (author), Michael Morse (20752772) (author), Herbert Lyerly (20752775) (author)
Published:	2025
Subjects:	Tumour Immunology T-DXd breast cancer HER2 antibody-drug-conjugates
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author	Zachary Hartman (20752724)
author2	Li-Chung Tsao (20752727) John Wang (20752730) Xingru Ma (20752733) Sirajbir Sodhi (20752736) Joey Ragusa (20752739) Bushanqing Liu (20752742) Jason McBane (20752745) Tao Wang (20752748) Junping Wei (20752751) Cong-Xiao Liu (20752754) Xiao Yang (20752757) Gangjun Lei (20752760) Ivan Spasojevic (20752763) Ping Fan (20752766) Timothy Trotter (20752769) Michael Morse (20752772) Herbert Lyerly (20752775)
author2_role	author author author author author author author author author author author author author author author author author
author_facet	Zachary Hartman (20752724) Li-Chung Tsao (20752727) John Wang (20752730) Xingru Ma (20752733) Sirajbir Sodhi (20752736) Joey Ragusa (20752739) Bushanqing Liu (20752742) Jason McBane (20752745) Tao Wang (20752748) Junping Wei (20752751) Cong-Xiao Liu (20752754) Xiao Yang (20752757) Gangjun Lei (20752760) Ivan Spasojevic (20752763) Ping Fan (20752766) Timothy Trotter (20752769) Michael Morse (20752772) Herbert Lyerly (20752775)
author_role	author
dc.creator.none.fl_str_mv	Zachary Hartman (20752724) Li-Chung Tsao (20752727) John Wang (20752730) Xingru Ma (20752733) Sirajbir Sodhi (20752736) Joey Ragusa (20752739) Bushanqing Liu (20752742) Jason McBane (20752745) Tao Wang (20752748) Junping Wei (20752751) Cong-Xiao Liu (20752754) Xiao Yang (20752757) Gangjun Lei (20752760) Ivan Spasojevic (20752763) Ping Fan (20752766) Timothy Trotter (20752769) Michael Morse (20752772) Herbert Lyerly (20752775)
dc.date.none.fl_str_mv	2025-04-03T07:02:41Z
dc.identifier.none.fl_str_mv	10.6084/m9.figshare.27919128.v1
dc.relation.none.fl_str_mv	https://figshare.com/articles/dataset/Effective_Extracellular_Payload_Release_and_Immunomodulatory_Interactions_govern_the_Therapeutic_Effect_of_Trastuzumab_Deruxtecan_T-DXd_/27919128
dc.rights.none.fl_str_mv	CC BY 4.0 info:eu-repo/semantics/openAccess
dc.subject.none.fl_str_mv	Tumour Immunology T-DXd breast cancer HER2 antibody-drug-conjugates
dc.title.none.fl_str_mv	Effective Extracellular Payload Release and Immunomodulatory Interactions govern the Therapeutic Effect of Trastuzumab Deruxtecan (T-DXd)
dc.type.none.fl_str_mv	Dataset info:eu-repo/semantics/publishedVersion dataset
description	Immunohistochemistry assessment of tumor infiltrating T cells levels and spatial location. CD8+ (brown), CD4+ (blue) and FoxP3+ (red). Tumors were from HER2 oncogene driven transgenic mice, and treatment were administered weekly for 4 weeks, 5.4mg/kg control IgG1, 5.4mg/kg T-DXd, and 15mg/kg anti-CD47 (MIAP410)
eu_rights_str_mv	openAccess
id	Manara_75d4e7be2a1fa062d8cf84216b436d4d
identifier_str_mv	10.6084/m9.figshare.27919128.v1
network_acronym_str	Manara
network_name_str	ManaraRepo
oai_identifier_str	oai:figshare.com:article/27919128
publishDate	2025
repository.mail.fl_str_mv
repository.name.fl_str_mv
repository_id_str
rights_invalid_str_mv	CC BY 4.0
spelling	Effective Extracellular Payload Release and Immunomodulatory Interactions govern the Therapeutic Effect of Trastuzumab Deruxtecan (T-DXd)Zachary Hartman (20752724)Li-Chung Tsao (20752727)John Wang (20752730)Xingru Ma (20752733)Sirajbir Sodhi (20752736)Joey Ragusa (20752739)Bushanqing Liu (20752742)Jason McBane (20752745)Tao Wang (20752748)Junping Wei (20752751)Cong-Xiao Liu (20752754)Xiao Yang (20752757)Gangjun Lei (20752760)Ivan Spasojevic (20752763)Ping Fan (20752766)Timothy Trotter (20752769)Michael Morse (20752772)Herbert Lyerly (20752775)Tumour ImmunologyT-DXdbreast cancerHER2antibody-drug-conjugatesImmunohistochemistry assessment of tumor infiltrating T cells levels and spatial location. CD8+ (brown), CD4+ (blue) and FoxP3+ (red). Tumors were from HER2 oncogene driven transgenic mice, and treatment were administered weekly for 4 weeks, 5.4mg/kg control IgG1, 5.4mg/kg T-DXd, and 15mg/kg anti-CD47 (MIAP410)2025-04-03T07:02:41ZDatasetinfo:eu-repo/semantics/publishedVersiondataset10.6084/m9.figshare.27919128.v1https://figshare.com/articles/dataset/Effective_Extracellular_Payload_Release_and_Immunomodulatory_Interactions_govern_the_Therapeutic_Effect_of_Trastuzumab_Deruxtecan_T-DXd_/27919128CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/279191282025-04-03T07:02:41Z
spellingShingle	Effective Extracellular Payload Release and Immunomodulatory Interactions govern the Therapeutic Effect of Trastuzumab Deruxtecan (T-DXd) Zachary Hartman (20752724) Tumour Immunology T-DXd breast cancer HER2 antibody-drug-conjugates
status_str	publishedVersion
title	Effective Extracellular Payload Release and Immunomodulatory Interactions govern the Therapeutic Effect of Trastuzumab Deruxtecan (T-DXd)
title_full	Effective Extracellular Payload Release and Immunomodulatory Interactions govern the Therapeutic Effect of Trastuzumab Deruxtecan (T-DXd)
title_fullStr	Effective Extracellular Payload Release and Immunomodulatory Interactions govern the Therapeutic Effect of Trastuzumab Deruxtecan (T-DXd)
title_full_unstemmed	Effective Extracellular Payload Release and Immunomodulatory Interactions govern the Therapeutic Effect of Trastuzumab Deruxtecan (T-DXd)
title_short	Effective Extracellular Payload Release and Immunomodulatory Interactions govern the Therapeutic Effect of Trastuzumab Deruxtecan (T-DXd)
title_sort	Effective Extracellular Payload Release and Immunomodulatory Interactions govern the Therapeutic Effect of Trastuzumab Deruxtecan (T-DXd)
topic	Tumour Immunology T-DXd breast cancer HER2 antibody-drug-conjugates

Effective Extracellular Payload Release and Immunomodulatory Interactions govern the Therapeutic Effect of Trastuzumab Deruxtecan (T-DXd)

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