Visualization of NMF outputs and their relationship to single-cell behavior.

Visualization of NMF outputs and their relationship to single-cell behavior.

<p>a. UMAP visualization of contribution matrix, colored by the template with the predominant contribution in each cell. <b>b.</b> Depiction of cell coordinates from selected individual cells. <b>c.</b> Component contributions for each cell, emphasizing high weight for...

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Bibliographic Details
Main Author: Laura M. Gunsalus (9234497) (author)
Other Authors: Michael J. Keiser (260659) (author), Katherine S. Pollard (8685789) (author)
Published: 2025
Subjects:
Biophysics
Biochemistry
Cell Biology
Genetics
Molecular Biology
Biotechnology
Developmental Biology
Cancer
Hematology
Biological Sciences not elsewhere classified
Chemical Sciences not elsewhere classified
salient primary components
occurring uniformly across
negative matrix factorization
key functional phenotypes
including active transcription
identifying causal relationships
fostering new insights
identify trends accounting
individual dna molecules
individual chromatin fibers
genome organization may
bulk trends exist
molecule chromatin organization
individual molecules
chromatin organization
bulk trends
molecule data
genome structure
chromatin structure
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small fraction
simultaneously describing
robust tool
promoter distance
maximum variance
genomic compartment
critical changes
complex interplay
cellular heterogeneity
cell level
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