Figure 6 from Prostate Cancer Progression Modeling Provides Insight into Dynamic Molecular Changes Associated with Progressive Disease States
<p>BEAM identified branch-dependent genes and molecular pathways associated with the divergence of <i>ERG</i> fusion–negative (path A) and <i>ERG</i> fusion–positive (path C) tumors. <b>A,</b> Heatmap of identified branch-dependent genes. The expression data...
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2025
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| Summary: | <p>BEAM identified branch-dependent genes and molecular pathways associated with the divergence of <i>ERG</i> fusion–negative (path A) and <i>ERG</i> fusion–positive (path C) tumors. <b>A,</b> Heatmap of identified branch-dependent genes. The expression data of each gene were normalized into the range of (−1, 1) and smoothed by a natural spline function (df = 3). Based on expression patterns, the genes were clustered into six gene modules. <b>B,</b> Average expression curves of the six gene modules for the two paths. The broken lines indicate the branching events. <b>C,</b> Highlighted genes and KEGG pathways significantly enriched in each gene module. No pathways were identified to be significantly enriched in module 6.</p> |
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