KEGG pathway enrichment analysis of differential serum metabolites.

<p>Each dot represents a metabolic pathway. The x-axis shows the pathway impact score, while the y-axis indicates–log₁₀ (<i>P</i> value). Dot size reflects the impact score, and the color gradient from yellow to red corresponds to increasing statistical significance. Results are sh...

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Bibliographic Details
Main Author:	Ji-Xin Zhao (22056386) (author)
Other Authors:	Wen-Bin Zheng (3328680) (author), Shi-Chen Xie (10678094) (author), He Ma (583317) (author), Xiao-Tong Chen (4217488) (author), Ying-Qian Gao (22683622) (author), Lu-Yao Tang (22683625) (author), Meng-Ting Yang (10714266) (author), Fu-Long Nan (22056395) (author), Jing Jiang (130103) (author), Hany M. Elsheikha (6910232) (author), Xiao-Xuan Zhang (610969) (author)
Published:	2025
Subjects:	Biochemistry Microbiology Cell Biology Genetics Physiology Ecology Immunology Computational Biology Biological Sciences not elsewhere classified Chemical Sciences not elsewhere classified showed negative associations quality reads produced oxidative stress response conducted metagenomic sequencing compositional changes coincided bile acid transformation aromatic compound processing 7 million genes rothia nasimurium </ lactobacillus intestinalis </ de novo </ untargeted serum metabolomics specific metabolic disruptions amino acid metabolism toxoplasma gondii </ limosilactobacillus reuteri </ lactobacillus johnsonii </ akkermansia muciniphila </ host systemic metabolism disrupts intestinal microbiota reuteri </ muciniphila </ johnsonii </ gondii </ host metabolism untargeted lc metabolic targets energy metabolism infection disrupts significant shifts reduced abundance rat model positively correlated pathways related novel microbial microbial diversity metabolites implicated marked reduction marked depletion key role immune modulation gut microbiota findings demonstrate enhanced glycan disease mechanisms comprehensive non community structure chronic stages active enzymes 18 sprague
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Summary:	<p>Each dot represents a metabolic pathway. The x-axis shows the pathway impact score, while the y-axis indicates–log₁₀ (<i>P</i> value). Dot size reflects the impact score, and the color gradient from yellow to red corresponds to increasing statistical significance. Results are shown for <b>(A)</b> control (CON) vs. acute infection (AI), <b>(B)</b> CON vs. chronic infection (CI), and <b>(C)</b> AI vs. CI.</p>

KEGG pathway enrichment analysis of differential serum metabolites.

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